SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fjk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		5 / 11 ALA A 171
LEU A 136
ILE A 174
ILE A 234
ILE A 250
 None
 1.02A 1dyrA-2fjkA:
undetectable		 1dyrA-2fjkA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		5 / 11 ALA A  32
THR A  24
VAL A  64
LEU A  67
ALA A  68
 None
 1.02A 1jinA-2fjkA:
undetectable		 1jinA-2fjkA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		5 / 12 THR A 252
GLY A 209
GLY A 179
PHE A  22
ASP A 255
 None
13P  A1063 (-3.0A)
13P  A1063 (-3.9A)
None
None
 1.00A 1wg8B-2fjkA:
undetectable		 1wg8B-2fjkA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		4 / 8 LEU A   9
ASN A 251
GLU A 130
HIS A 208
 None
13P  A1063 (-3.5A)
None
13P  A1063 (-3.3A)
 0.93A 2bnnA-2fjkA:
undetectable
2bnnB-2fjkA:
undetectable		 2bnnA-2fjkA:
21.71
2bnnB-2fjkA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		4 / 7 ASP A  80
ALA A  47
GLY A  20
ILE A 250
 13P  A1063 (-3.1A)
None
None
None
 0.91A 2fxdB-2fjkA:
undetectable		 2fxdB-2fjkA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		4 / 7 THR A  61
GLY A  57
LEU A  79
PHE A  96
 None
 1.04A 2vl2B-2fjkA:
undetectable		 2vl2B-2fjkA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		4 / 6 PRO A  43
LEU A   9
ALA A  76
PRO A  74
 None
 1.34A 3gv1A-2fjkA:
undetectable
3gv1C-2fjkA:
undetectable		 3gv1A-2fjkA:
17.38
3gv1C-2fjkA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		4 / 6 LEU A   9
ALA A  76
PRO A  74
PRO A  43
 None
 1.35A 3gv1A-2fjkA:
undetectable
3gv1B-2fjkA:
undetectable		 3gv1A-2fjkA:
17.38
3gv1B-2fjkA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		3 / 3 VAL A  73
VAL A  19
SER A 301
 None
 0.58A 3n8xB-2fjkA:
undetectable		 3n8xB-2fjkA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		5 / 12 PHE A 299
GLY A  20
GLY A 300
SER A 301
ALA A 305
 None
 1.29A 3sueD-2fjkA:
undetectable		 3sueD-2fjkA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		5 / 12 ILE A 189
LEU A 194
GLY A 209
ALA A 210
GLY A 233
 None
None
13P  A1063 (-3.0A)
None
None
 0.93A 3uq6B-2fjkA:
undetectable		 3uq6B-2fjkA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		5 / 12 ILE A 189
LEU A 194
GLY A 209
ALA A 210
GLY A 233
 None
None
13P  A1063 (-3.0A)
None
None
 0.92A 3vaqB-2fjkA:
undetectable		 3vaqB-2fjkA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		4 / 6 ALA A 259
LEU A 263
VAL A 264
GLU A  28
 None
 0.87A 4g24A-2fjkA:
undetectable		 4g24A-2fjkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		5 / 12 LEU A 207
ALA A  47
ILE A 243
LEU A   9
GLY A  16
 None
 1.34A 4l9qA-2fjkA:
undetectable		 4l9qA-2fjkA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		5 / 12 GLU A 297
GLY A  20
GLU A 130
PHE A  22
LEU A 256
 None
 1.25A 4retA-2fjkA:
undetectable		 4retA-2fjkA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		5 / 12 GLU A 297
GLY A  20
GLU A 130
PHE A  22
LEU A 256
 None
 1.25A 4retC-2fjkA:
undetectable		 4retC-2fjkA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		4 / 6 LEU A 133
PHE A 161
THR A 165
VAL A 119
 None
 1.02A 4udaA-2fjkA:
undetectable		 4udaA-2fjkA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		4 / 7 ASP A 255
GLY A 179
THR A 252
LYS A 182
 None
13P  A1063 (-3.9A)
None
13P  A1063 (-2.6A)
 1.18A 4zxiA-2fjkA:
undetectable		 4zxiA-2fjkA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		4 / 5 ILE A 228
GLN A 215
ARG A 222
GLU A 216
 None
 1.45A 5fseC-2fjkA:
2.6		 5fseC-2fjkA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE
(Thermus
caldophilus) 		4 / 5 GLU A 114
THR A 115
GLU A 120
LEU A  92
 None
 1.28A 5hm8G-2fjkA:
2.4		 5hm8G-2fjkA:
20.76