SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fk5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE
(Thermus
thermophilus) 		4 / 4 ARG A 144
ALA A  83
ALA A 165
GLU A 168
 None
 1.16A 1e7bB-2fk5A:
undetectable		 1e7bB-2fk5A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE
(Thermus
thermophilus) 		5 / 12 ALA A  85
ARG A 144
LEU A 158
GLU A 168
ALA A 165
 None
 1.02A 1mjqC-2fk5A:
undetectable
1mjqD-2fk5A:
undetectable		 1mjqC-2fk5A:
22.11
1mjqD-2fk5A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE
(Thermus
thermophilus) 		5 / 12 ALA A  85
ARG A 144
LEU A 158
GLU A 168
ALA A 165
 None
 1.02A 1mjqI-2fk5A:
undetectable
1mjqJ-2fk5A:
undetectable		 1mjqI-2fk5A:
22.11
1mjqJ-2fk5A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE
(Thermus
thermophilus) 		5 / 12 LEU A 140
ASN A  28
LEU A 148
GLY A 152
HIS A  88
 None
SO4  A1001 (-3.9A)
None
None
None
 1.43A 3g1uA-2fk5A:
undetectable		 3g1uA-2fk5A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE
(Thermus
thermophilus) 		3 / 3 HIS A  88
HIS A  90
HIS A 151
 None
 0.54A 3qpkA-2fk5A:
undetectable		 3qpkA-2fk5A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE
(Thermus
thermophilus) 		3 / 3 HIS A  88
HIS A  90
HIS A 151
 None
 0.51A 3qpkB-2fk5A:
undetectable		 3qpkB-2fk5A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE
(Thermus
thermophilus) 		5 / 12 GLY A  27
ARG A 144
GLY A 152
ALA A 155
ALA A 145
 None
 0.89A 3sudA-2fk5A:
undetectable		 3sudA-2fk5A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE
(Thermus
thermophilus) 		5 / 12 GLY A  27
ARG A 144
GLY A 152
ALA A 155
ALA A 145
 None
 1.03A 3sueB-2fk5A:
undetectable		 3sueB-2fk5A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE
(Thermus
thermophilus) 		5 / 12 GLY A  27
ARG A 144
GLY A 152
ALA A 155
ALA A 145
 None
 1.07A 3sufA-2fk5A:
undetectable		 3sufA-2fk5A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE
(Thermus
thermophilus) 		5 / 11 SER A  71
ILE A  39
LEU A   5
GLY A  36
PHE A  37
 None
 1.22A 4fogA-2fk5A:
undetectable		 4fogA-2fk5A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE
(Thermus
thermophilus) 		5 / 11 SER A  71
ILE A  39
LEU A   5
GLY A  36
PHE A  37
 None
 1.31A 4fogC-2fk5A:
undetectable		 4fogC-2fk5A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE
(Thermus
thermophilus) 		4 / 6 GLY A  27
ALA A 128
GLU A  70
GLN A  45
 None
 1.09A 4g0uA-2fk5A:
undetectable		 4g0uA-2fk5A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE
(Thermus
thermophilus) 		4 / 4 VAL A  72
THR A 129
GLU A 130
GLU A 131
 None
 1.28A 4l78A-2fk5A:
undetectable		 4l78A-2fk5A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE
(Thermus
thermophilus) 		4 / 8 ALA A 153
MET A 173
PHE A  29
THR A  40
 None
 0.99A 4ltwA-2fk5A:
undetectable		 4ltwA-2fk5A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE
(Thermus
thermophilus) 		4 / 8 ALA A 153
PHE A  29
THR A  40
VAL A  44
 None
 0.96A 4ltwA-2fk5A:
undetectable		 4ltwA-2fk5A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE
(Thermus
thermophilus) 		4 / 4 TYR A 114
THR A 175
GLY A 111
LEU A 109
 None
 1.34A 4w5nA-2fk5A:
undetectable		 4w5nA-2fk5A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE
(Thermus
thermophilus) 		4 / 6 LEU A  54
LEU A  55
GLU A  56
ILE A  39
 None
 0.96A 4ww7A-2fk5A:
undetectable		 4ww7A-2fk5A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE
(Thermus
thermophilus) 		3 / 3 HIS A  88
HIS A  90
HIS A 151
 None
 0.55A 5migA-2fk5A:
undetectable		 5migA-2fk5A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE
(Thermus
thermophilus) 		5 / 12 GLY A  27
ARG A 144
GLY A 152
ALA A 155
ALA A 145
 None
 1.00A 6c2mD-2fk5A:
undetectable		 6c2mD-2fk5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE
(Thermus
thermophilus) 		5 / 12 ALA A 161
LEU A   5
VAL A  57
HIS A  74
LEU A 167
 None
 1.15A 6djzC-2fk5A:
undetectable		 6djzC-2fk5A:
23.27