SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fk7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		11 / 12 THR A  41
TYR A  42
ILE A  80
GLY A  81
GLY A  83
LEU A 104
GLY A 131
TRP A 132
GLU A 133
ILE A 145
ALA A 147
 None
 0.47A 2fk8A-2fk7A:
44.8		 2fk8A-2fk7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		9 / 12 THR A  86
ILE A  80
GLY A  81
GLY A  83
LEU A 104
GLY A 131
TRP A 132
GLU A 133
ALA A 147
 None
 1.46A 2fk8A-2fk7A:
44.8		 2fk8A-2fk7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		3 / 3 SER A  43
THR A 103
GLN A 108
 None
 0.19A 2fk8A-2fk7A:
44.8		 2fk8A-2fk7A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 101
GLN A 126
ILE A  80
GLN A 130
 None
 0.91A 3fi0P-2fk7A:
undetectable		 3fi0P-2fk7A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 137
PHE A 135
GLN A 126
 None
 0.84A 3r55A-2fk7A:
undetectable		 3r55A-2fk7A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 241
GLU A 146
TYR A 274
LEU A 275
 None
 1.05A 3rqwC-2fk7A:
undetectable
3rqwD-2fk7A:
undetectable		 3rqwC-2fk7A:
18.10
3rqwD-2fk7A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 146
TYR A 274
LEU A 275
TYR A 241
 None
 1.07A 3rqwF-2fk7A:
undetectable
3rqwJ-2fk7A:
undetectable		 3rqwF-2fk7A:
18.10
3rqwJ-2fk7A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		3 / 3 GLY A  83
GLY A  85
THR A  87
 None
 0.29A 3si7B-2fk7A:
undetectable		 3si7B-2fk7A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		4 / 4 LEU A  54
ILE A 145
TYR A  59
TYR A 241
 None
 1.29A 3vt7A-2fk7A:
undetectable		 3vt7A-2fk7A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		4 / 8 TYR A  59
VAL A  62
ILE A 145
GLU A  93
 None
 0.96A 4a97D-2fk7A:
undetectable		 4a97D-2fk7A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		4 / 7 TYR A  59
VAL A  62
ILE A 145
GLU A  93
 None
 0.95A 4a97H-2fk7A:
undetectable		 4a97H-2fk7A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  81
GLY A  83
THR A 103
LEU A 104
GLN A 108
 None
 0.55A 4f84A-2fk7A:
24.6		 4f84A-2fk7A:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 131
ASN A 155
GLU A 133
GLN A 108
 None
 1.27A 4g0vB-2fk7A:
undetectable		 4g0vB-2fk7A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  81
GLY A  83
SER A 105
ILE A 145
ALA A 147
 None
 0.61A 4qtuB-2fk7A:
15.0		 4qtuB-2fk7A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  81
GLY A  83
SER A 105
ILE A 145
ALA A 147
 None
 0.52A 4qtuD-2fk7A:
15.3		 4qtuD-2fk7A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  81
GLY A  83
GLY A  85
LEU A 104
ALA A 147
 None
 1.00A 4uciA-2fk7A:
6.2		 4uciA-2fk7A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  81
GLY A  83
GLY A  85
LEU A 104
ALA A 147
 None
 0.99A 4uciB-2fk7A:
5.7		 4uciB-2fk7A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		4 / 6 TRP A  84
GLY A  85
THR A  86
VAL A 115
 None
 1.14A 5ewuA-2fk7A:
2.1		 5ewuA-2fk7A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		4 / 6 TRP A  84
GLY A  85
THR A  86
VAL A 115
 None
 1.13A 5ewuB-2fk7A:
undetectable		 5ewuB-2fk7A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  81
GLY A  83
THR A 103
GLN A 108
VAL A 143
 None
 1.04A 5kocB-2fk7A:
24.5		 5kocB-2fk7A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		5 / 12 SER A  43
GLY A  81
GLY A  83
THR A 103
GLN A 108
 None
 0.55A 5kocB-2fk7A:
24.5		 5kocB-2fk7A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		5 / 12 SER A  43
GLY A  81
GLY A  83
SER A 105
GLN A 108
 None
 0.82A 5kpcB-2fk7A:
24.8		 5kpcB-2fk7A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		5 / 12 ARG A  89
GLY A  85
GLY A  83
ILE A 145
LEU A  69
 None
 1.21A 5ul4A-2fk7A:
2.1		 5ul4A-2fk7A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4
(Mycobacterium
tuberculosis) 		4 / 6 GLN A  36
VAL A  27
LEU A  54
ARG A 246
 None
 1.28A 6brdB-2fk7A:
undetectable		 6brdB-2fk7A:
13.48