SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fk9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 2fk9 PROTEIN KINASE C,
ETA TYPE
(Homo
sapiens) 		4 / 7 HIS A  88
THR A  59
TYR A  68
HIS A  96
 None
 1.49A 1v54A-2fk9A:
undetectable
1v54C-2fk9A:
undetectable		 1v54A-2fk9A:
14.84
1v54C-2fk9A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fk9 PROTEIN KINASE C,
ETA TYPE
(Homo
sapiens) 		4 / 7 HIS A  88
THR A  59
TYR A  68
HIS A  96
 None
 1.50A 2dyrN-2fk9A:
undetectable
2dyrP-2fk9A:
undetectable		 2dyrN-2fk9A:
14.84
2dyrP-2fk9A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fk9 PROTEIN KINASE C,
ETA TYPE
(Homo
sapiens) 		4 / 6 HIS A  88
THR A  59
TYR A  68
HIS A  96
 None
 1.47A 2dysA-2fk9A:
undetectable
2dysC-2fk9A:
undetectable		 2dysA-2fk9A:
14.84
2dysC-2fk9A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fk9 PROTEIN KINASE C,
ETA TYPE
(Homo
sapiens) 		4 / 7 HIS A  88
THR A  59
TYR A  68
HIS A  96
 None
 1.46A 2eilA-2fk9A:
undetectable
2eilC-2fk9A:
undetectable		 2eilA-2fk9A:
14.84
2eilC-2fk9A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fk9 PROTEIN KINASE C,
ETA TYPE
(Homo
sapiens) 		4 / 6 HIS A  88
THR A  59
TYR A  68
HIS A  96
 None
 1.49A 2eimN-2fk9A:
undetectable
2eimP-2fk9A:
undetectable		 2eimN-2fk9A:
14.84
2eimP-2fk9A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fk9 PROTEIN KINASE C,
ETA TYPE
(Homo
sapiens) 		4 / 7 HIS A  88
THR A  59
TYR A  68
HIS A  96
 None
 1.47A 2y69A-2fk9A:
undetectable
2y69C-2fk9A:
undetectable		 2y69A-2fk9A:
14.84
2y69C-2fk9A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fk9 PROTEIN KINASE C,
ETA TYPE
(Homo
sapiens) 		4 / 6 HIS A  88
THR A  59
TYR A  68
HIS A  96
 None
 1.46A 2zxwA-2fk9A:
undetectable
2zxwC-2fk9A:
undetectable		 2zxwA-2fk9A:
14.84
2zxwC-2fk9A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fk9 PROTEIN KINASE C,
ETA TYPE
(Homo
sapiens) 		4 / 6 HIS A  88
THR A  59
TYR A  68
HIS A  96
 None
 1.46A 2zxwN-2fk9A:
undetectable
2zxwP-2fk9A:
undetectable		 2zxwN-2fk9A:
14.84
2zxwP-2fk9A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fk9 PROTEIN KINASE C,
ETA TYPE
(Homo
sapiens) 		4 / 7 HIS A  88
THR A  59
TYR A  68
HIS A  96
 None
 1.48A 3abkA-2fk9A:
undetectable
3abkC-2fk9A:
undetectable		 3abkA-2fk9A:
14.84
3abkC-2fk9A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fk9 PROTEIN KINASE C,
ETA TYPE
(Homo
sapiens) 		4 / 7 HIS A  88
THR A  59
TYR A  68
HIS A  96
 None
 1.49A 3abmN-2fk9A:
undetectable
3abmP-2fk9A:
undetectable		 3abmN-2fk9A:
14.84
3abmP-2fk9A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fk9 PROTEIN KINASE C,
ETA TYPE
(Homo
sapiens) 		4 / 7 HIS A  88
THR A  59
TYR A  68
HIS A  96
 None
 1.47A 3ag2A-2fk9A:
undetectable
3ag2C-2fk9A:
undetectable		 3ag2A-2fk9A:
14.84
3ag2C-2fk9A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fk9 PROTEIN KINASE C,
ETA TYPE
(Homo
sapiens) 		4 / 7 HIS A  88
THR A  59
TYR A  68
HIS A  96
 None
 1.49A 3ag3N-2fk9A:
undetectable
3ag3P-2fk9A:
undetectable		 3ag3N-2fk9A:
14.84
3ag3P-2fk9A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fk9 PROTEIN KINASE C,
ETA TYPE
(Homo
sapiens) 		4 / 6 HIS A  88
THR A  59
TYR A  68
HIS A  96
 None
 1.47A 3asnA-2fk9A:
undetectable
3asnC-2fk9A:
undetectable		 3asnA-2fk9A:
14.84
3asnC-2fk9A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2fk9 PROTEIN KINASE C,
ETA TYPE
(Homo
sapiens) 		5 / 8 LEU A 108
VAL A  76
LEU A  12
VAL A  49
LEU A  82
 None
 1.28A 3kp6A-2fk9A:
undetectable
3kp6B-2fk9A:
undetectable		 3kp6A-2fk9A:
22.73
3kp6B-2fk9A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2fk9 PROTEIN KINASE C,
ETA TYPE
(Homo
sapiens) 		4 / 6 SER A 115
GLY A 120
GLU A 119
ASP A 123
 None
 1.01A 4uckB-2fk9A:
undetectable		 4uckB-2fk9A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 2fk9 PROTEIN KINASE C,
ETA TYPE
(Homo
sapiens) 		5 / 12 LEU A 108
SER A 115
GLU A 119
VAL A 133
ARG A  15
 None
 1.31A 5o4yD-2fk9A:
undetectable
5o4yE-2fk9A:
undetectable		 5o4yD-2fk9A:
5.41
5o4yE-2fk9A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2fk9 PROTEIN KINASE C,
ETA TYPE
(Homo
sapiens) 		5 / 12 GLY A  21
THR A  67
TYR A  68
CYH A 101
LEU A  45
 None
 1.45A 6bp4A-2fk9A:
undetectable		 6bp4A-2fk9A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2fk9 PROTEIN KINASE C,
ETA TYPE
(Homo
sapiens) 		5 / 6 PHE A 105
VAL A  54
LEU A  84
LEU A  82
HIS A  81
 None
 1.30A 6e43A-2fk9A:
undetectable		 6e43A-2fk9A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2fk9 PROTEIN KINASE C,
ETA TYPE
(Homo
sapiens) 		5 / 6 PHE A 105
VAL A  54
LEU A  84
LEU A  82
HIS A  81
 None
 1.29A 6e43C-2fk9A:
undetectable		 6e43C-2fk9A:
18.38