SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fkb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 2fkb PUTATIVE NUDIX
HYDROLASE YFCD
(Escherichia
coli) 		5 / 10 VAL A  74
VAL A  75
VAL A  21
ILE A  14
VAL A  15
 GOL  A 904 (-3.9A)
None
GOL  A 903 (-4.0A)
None
None
 1.28A 2qboA-2fkbA:
undetectable		 2qboA-2fkbA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 2fkb PUTATIVE NUDIX
HYDROLASE YFCD
(Escherichia
coli) 		3 / 3 GLU A 102
PHE A 120
GLN A 105
 None
 1.01A 3r55A-2fkbA:
undetectable		 3r55A-2fkbA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2fkb PUTATIVE NUDIX
HYDROLASE YFCD
(Escherichia
coli) 		4 / 5 THR A 142
ILE A  51
LYS A  50
PHE A 153
 None
 1.29A 4acaC-2fkbA:
undetectable		 4acaC-2fkbA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2fkb PUTATIVE NUDIX
HYDROLASE YFCD
(Escherichia
coli) 		3 / 3 SER A 124
GLU A  92
GLU A  79
 None
 0.87A 4ymgB-2fkbA:
undetectable		 4ymgB-2fkbA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 2fkb PUTATIVE NUDIX
HYDROLASE YFCD
(Escherichia
coli) 		4 / 7 THR A 154
ASP A 156
TYR A  41
GLY A  73
 None
None
None
GOL  A 904 (-3.3A)
 1.10A 5hwaA-2fkbA:
undetectable		 5hwaA-2fkbA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 2fkb PUTATIVE NUDIX
HYDROLASE YFCD
(Escherichia
coli) 		5 / 12 GLY A  73
TRP A 116
HIS A  37
VAL A  12
GLU A  79
 GOL  A 904 (-3.3A)
None
None
None
None
 1.36A 6gngA-2fkbA:
undetectable		 6gngA-2fkbA:
15.74