SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fkj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 2fkj OUTER SURFACE
PROTEIN A
(Borreliella
burgdorferi) 		5 / 10 GLU A 215
GLU A 216
LEU A 201
GLU A 193
GLU A 192
 None
 1.28A 1a29A-2fkjA:
undetectable		 1a29A-2fkjA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2fkj OUTER SURFACE
PROTEIN A
(Borreliella
burgdorferi) 		4 / 7 THR A  98
GLU A 100
THR A  89
VAL A  75
 None
 0.64A 3em0B-2fkjA:
3.2		 3em0B-2fkjA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2fkj OUTER SURFACE
PROTEIN A
(Borreliella
burgdorferi) 		4 / 8 GLY A  65
ILE A  90
VAL A  40
VAL A  42
 None
 0.80A 3fi0I-2fkjA:
undetectable		 3fi0I-2fkjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 2fkj OUTER SURFACE
PROTEIN A
(Borreliella
burgdorferi) 		4 / 8 ILE A 358
PHE A 352
GLU A 297
LEU A 380
 None
 0.87A 3ua5A-2fkjA:
undetectable		 3ua5A-2fkjA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 2fkj OUTER SURFACE
PROTEIN A
(Borreliella
burgdorferi) 		5 / 11 LEU A  41
VAL A  42
LEU A  88
GLY A  74
LEU A  34
 None
 1.25A 4zbqA-2fkjA:
undetectable		 4zbqA-2fkjA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2fkj OUTER SURFACE
PROTEIN A
(Borreliella
burgdorferi) 		5 / 12 THR A 287
THR A 291
THR A 292
SER A 270
GLY A 271
 None
 1.24A 5l5zV-2fkjA:
undetectable
5l5zb-2fkjA:
undetectable		 5l5zV-2fkjA:
19.51
5l5zb-2fkjA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2fkj OUTER SURFACE
PROTEIN A
(Borreliella
burgdorferi) 		5 / 12 THR A 287
THR A 291
THR A 292
SER A 270
GLY A 271
 None
 1.23A 5l5zH-2fkjA:
undetectable
5l5zN-2fkjA:
undetectable		 5l5zH-2fkjA:
19.51
5l5zN-2fkjA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 2fkj OUTER SURFACE
PROTEIN A
(Borreliella
burgdorferi) 		5 / 12 THR A 287
THR A 291
THR A 292
SER A 270
GLY A 271
 None
 1.26A 5lf3b-2fkjA:
undetectable		 5lf3b-2fkjA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2fkj OUTER SURFACE
PROTEIN A
(Borreliella
burgdorferi) 		4 / 8 VAL A  32
GLY A  74
LEU A  76
THR A  89
 None
 1.10A 5sxqB-2fkjA:
undetectable		 5sxqB-2fkjA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 2fkj OUTER SURFACE
PROTEIN A
(Borreliella
burgdorferi) 		4 / 8 VAL A  32
GLY A  74
LEU A  76
THR A  89
 None
 1.05A 5syjA-2fkjA:
undetectable		 5syjA-2fkjA:
19.67