SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fkn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 10 GLY A 488
HIS A 497
ALA A 130
GLY A 499
SER A 132
 None
 0.97A 1c9sN-2fknA:
undetectable
1c9sO-2fknA:
0.3		 1c9sN-2fknA:
9.42
1c9sO-2fknA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 11 GLY A 488
HIS A 497
ALA A 130
GLY A 499
SER A 132
 None
 0.98A 1c9sP-2fknA:
undetectable
1c9sQ-2fknA:
undetectable		 1c9sP-2fknA:
9.42
1c9sQ-2fknA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 10 GLY A 499
SER A 132
GLY A 488
HIS A 497
ALA A 130
 None
 0.98A 1c9sL-2fknA:
undetectable
1c9sV-2fknA:
undetectable		 1c9sL-2fknA:
9.42
1c9sV-2fknA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 11 GLY A 488
HIS A 497
ALA A 130
GLY A 499
SER A 132
 None
 0.98A 1gtfQ-2fknA:
undetectable
1gtfR-2fknA:
undetectable		 1gtfQ-2fknA:
9.42
1gtfR-2fknA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 11 GLY A 488
HIS A 497
ALA A 130
GLY A 499
SER A 132
 None
 0.99A 1gtfS-2fknA:
undetectable
1gtfT-2fknA:
undetectable		 1gtfS-2fknA:
9.42
1gtfT-2fknA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 11 GLY A 488
HIS A 497
ALA A 130
GLY A 499
SER A 132
 None
 1.02A 1gtnT-2fknA:
undetectable
1gtnU-2fknA:
undetectable		 1gtnT-2fknA:
9.42
1gtnU-2fknA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		3 / 3 ARG A 414
GLY A 444
ASP A 442
 None
 0.58A 1kf6A-2fknA:
3.2
1kf6B-2fknA:
undetectable		 1kf6A-2fknA:
24.26
1kf6B-2fknA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		3 / 3 ARG A 414
ILE A 406
TRP A 408
 None
 0.91A 1m8eB-2fknA:
undetectable		 1m8eB-2fknA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 6 LEU A 441
ASP A 442
GLY A 353
ARG A 414
 NAD  A5555 (-4.5A)
None
None
None
 0.61A 1mt1G-2fknA:
undetectable
1mt1J-2fknA:
undetectable		 1mt1G-2fknA:
7.85
1mt1J-2fknA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 7 ARG A 414
LEU A 441
ASP A 442
GLY A 353
 None
NAD  A5555 (-4.5A)
None
None
 0.63A 1mt1H-2fknA:
undetectable
1mt1K-2fknA:
undetectable		 1mt1H-2fknA:
12.68
1mt1K-2fknA:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 7 ARG A 414
LEU A 441
ASP A 442
GLY A 353
 None
NAD  A5555 (-4.5A)
None
None
 0.63A 1n13D-2fknA:
undetectable
1n13E-2fknA:
undetectable		 1n13D-2fknA:
12.68
1n13E-2fknA:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 8 LEU A 441
ASP A 442
GLY A 353
ARG A 414
 NAD  A5555 (-4.5A)
None
None
None
 0.65A 1n13A-2fknA:
undetectable
1n13F-2fknA:
undetectable		 1n13A-2fknA:
7.85
1n13F-2fknA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 6 ARG A 414
LEU A 441
ASP A 442
GLY A 353
 None
NAD  A5555 (-4.5A)
None
None
 0.64A 1n13H-2fknA:
undetectable
1n13K-2fknA:
undetectable		 1n13H-2fknA:
12.68
1n13K-2fknA:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 7 LEU A 441
ASP A 442
GLY A 353
ARG A 414
 NAD  A5555 (-4.5A)
None
None
None
 0.64A 1n13G-2fknA:
undetectable
1n13J-2fknA:
undetectable		 1n13G-2fknA:
7.85
1n13J-2fknA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		3 / 3 ARG A 414
ILE A 406
TRP A 408
 None
 0.88A 1nodB-2fknA:
undetectable		 1nodB-2fknA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		3 / 3 ARG A 414
ILE A 406
TRP A 408
 None
 0.98A 1qomA-2fknA:
undetectable		 1qomA-2fknA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 12 GLY A 488
HIS A 497
ALA A 130
GLY A 499
SER A 132
 None
 1.01A 1utdO-2fknA:
undetectable
1utdP-2fknA:
undetectable		 1utdO-2fknA:
9.42
1utdP-2fknA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 11 GLY A 488
HIS A 497
ALA A 130
GLY A 499
SER A 132
 None
 1.01A 1utdP-2fknA:
undetectable
1utdQ-2fknA:
undetectable		 1utdP-2fknA:
9.42
1utdQ-2fknA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 11 GLY A 488
HIS A 497
ALA A 130
GLY A 499
SER A 132
 None
 1.01A 1utdS-2fknA:
undetectable
1utdT-2fknA:
undetectable		 1utdS-2fknA:
9.42
1utdT-2fknA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 10 GLY A 488
HIS A 497
ALA A 130
GLY A 499
SER A 132
 None
 1.03A 1utdU-2fknA:
undetectable
1utdV-2fknA:
undetectable		 1utdU-2fknA:
9.42
1utdV-2fknA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		3 / 3 ARG A 358
VAL A 446
GLY A 487
 ACT  A 553 (-2.7A)
None
None
 0.63A 2avvE-2fknA:
undetectable		 2avvE-2fknA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		3 / 3 ARG A 414
ILE A 406
TRP A 408
 None
 0.91A 2nodB-2fknA:
undetectable		 2nodB-2fknA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 7 ARG A 414
LEU A 441
ASP A 442
GLY A 353
 None
NAD  A5555 (-4.5A)
None
None
 0.68A 2qqcD-2fknA:
undetectable
2qqcE-2fknA:
undetectable		 2qqcD-2fknA:
12.84
2qqcE-2fknA:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 8 ARG A 414
LEU A 441
ASP A 442
GLY A 353
 None
NAD  A5555 (-4.5A)
None
None
 0.67A 2qqcH-2fknA:
undetectable
2qqcK-2fknA:
undetectable		 2qqcH-2fknA:
12.84
2qqcK-2fknA:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 8 ARG A 414
LEU A 441
ASP A 442
GLY A 353
 None
NAD  A5555 (-4.5A)
None
None
 0.67A 2qqdB-2fknA:
undetectable
2qqdC-2fknA:
undetectable		 2qqdB-2fknA:
12.84
2qqdC-2fknA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 6 TYR A 275
ALA A 280
LEU A 283
ALA A 295
 None
 0.92A 3b6hA-2fknA:
undetectable		 3b6hA-2fknA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		3 / 3 ARG A 414
ILE A 406
TRP A 408
 None
 0.90A 3e68A-2fknA:
undetectable		 3e68A-2fknA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		3 / 3 ARG A 414
ILE A 406
TRP A 408
 None
 0.89A 3e6tB-2fknA:
undetectable		 3e6tB-2fknA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		3 / 3 ARG A 414
ILE A 406
TRP A 408
 None
 0.87A 3e7iB-2fknA:
undetectable		 3e7iB-2fknA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 12 GLY A 170
GLY A 172
GLU A 193
ASP A 195
ALA A 240
 NAD  A5555 ( 4.0A)
NAD  A5555 (-3.3A)
NAD  A5555 (-2.8A)
None
NAD  A5555 (-3.6A)
 0.73A 3fuuA-2fknA:
6.6		 3fuuA-2fknA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 11 GLY A 170
GLY A 172
GLU A 193
ASP A 195
ALA A 240
 NAD  A5555 ( 4.0A)
NAD  A5555 (-3.3A)
NAD  A5555 (-2.8A)
None
NAD  A5555 (-3.6A)
 0.37A 3grvA-2fknA:
7.9		 3grvA-2fknA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 12 GLY A 170
GLY A 172
GLU A 193
ASP A 195
ALA A 240
 NAD  A5555 ( 4.0A)
NAD  A5555 (-3.3A)
NAD  A5555 (-2.8A)
None
NAD  A5555 (-3.6A)
 0.31A 3gryA-2fknA:
7.8		 3gryA-2fknA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		3 / 3 ARG A 154
ILE A 315
THR A 168
 None
 0.51A 3ia4D-2fknA:
undetectable		 3ia4D-2fknA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB315_0
(UNCHARACTERIZED
PROTEIN)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 12 THR A 166
ILE A 234
THR A 168
PHE A 149
LYS A 230
 None
 1.46A 3ijdB-2fknA:
0.0		 3ijdB-2fknA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 11 PRO A 449
VAL A 326
ALA A 327
PHE A 336
ILE A 323
 None
 1.38A 3n23A-2fknA:
undetectable		 3n23A-2fknA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		3 / 3 ARG A 414
ILE A 406
TRP A 408
 None
 1.00A 3nw2A-2fknA:
undetectable		 3nw2A-2fknA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		3 / 3 ARG A 414
ILE A 406
TRP A 408
 None
 0.94A 3nw2B-2fknA:
undetectable		 3nw2B-2fknA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 9 ASP A 521
SER A 520
ASN A 470
GLY A 444
ASP A 442
 None
 1.30A 3sfuA-2fknA:
undetectable		 3sfuA-2fknA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		3 / 3 LYS A 230
PRO A 231
LEU A 232
 None
 0.54A 3tpxE-2fknA:
undetectable		 3tpxE-2fknA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 7 ALA A 344
PRO A 343
ARG A 451
ARG A 324
 None
None
NAD  A5555 (-4.1A)
None
 1.11A 3twpA-2fknA:
3.0		 3twpA-2fknA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 7 ALA A 344
PRO A 343
ARG A 451
ARG A 324
 None
None
NAD  A5555 (-4.1A)
None
 1.05A 3twpB-2fknA:
3.1		 3twpB-2fknA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		3 / 3 ARG A  12
MET A  29
ARG A  28
 None
 1.33A 3uvvA-2fknA:
0.0		 3uvvA-2fknA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 12 ASN A 185
VAL A 189
THR A 166
LEU A 161
GLY A 175
 None
None
None
None
NAD  A5555 (-3.7A)
 0.86A 4dc3A-2fknA:
3.5		 4dc3A-2fknA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 12 ASN A 185
VAL A 189
THR A 166
LEU A 161
GLY A 176
 None
 0.87A 4dc3A-2fknA:
3.5		 4dc3A-2fknA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 12 ASN A 185
VAL A 189
THR A 166
LEU A 161
GLY A 175
 None
None
None
None
NAD  A5555 (-3.7A)
 0.90A 4dc3B-2fknA:
undetectable		 4dc3B-2fknA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 12 ASN A 185
VAL A 189
THR A 166
LEU A 161
GLY A 176
 None
 0.86A 4dc3B-2fknA:
undetectable		 4dc3B-2fknA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 8 GLU A 147
GLU A 186
GLY A 159
SER A 160
 None
 1.01A 4f93B-2fknA:
4.6		 4f93B-2fknA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 10 GLY A 410
GLY A 353
GLU A 413
ASN A 383
GLN A 143
 None
 1.46A 4fgkA-2fknA:
undetectable
4fgkB-2fknA:
undetectable		 4fgkA-2fknA:
19.89
4fgkB-2fknA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 12 GLY A 176
GLY A 175
ILE A 141
VAL A 397
GLN A 400
 None
NAD  A5555 (-3.7A)
NAD  A5555 (-4.4A)
None
None
 1.21A 4fglA-2fknA:
2.3
4fglB-2fknA:
undetectable		 4fglA-2fknA:
19.89
4fglB-2fknA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 12 GLU A 413
LEU A 518
GLU A 147
LEU A 376
ILE A 421
 None
 1.11A 4hytC-2fknA:
2.3		 4hytC-2fknA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 8 ASN A 422
GLU A 378
LEU A 375
LEU A 424
 None
 0.74A 4jjkA-2fknA:
undetectable		 4jjkA-2fknA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 7 LEU A 171
GLU A  40
GLY A 175
GLY A 176
 None
NAD  A5555 ( 4.8A)
NAD  A5555 (-3.7A)
None
 0.83A 5a06A-2fknA:
undetectable		 5a06A-2fknA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 7 LEU A 171
GLU A  40
GLY A 175
GLY A 176
 None
NAD  A5555 ( 4.8A)
NAD  A5555 (-3.7A)
None
 0.83A 5a06B-2fknA:
undetectable		 5a06B-2fknA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 7 LEU A 171
GLU A  40
GLY A 175
GLY A 176
 None
NAD  A5555 ( 4.8A)
NAD  A5555 (-3.7A)
None
 0.85A 5a06C-2fknA:
undetectable		 5a06C-2fknA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 7 LEU A 171
GLU A  40
GLY A 175
GLY A 176
 None
NAD  A5555 ( 4.8A)
NAD  A5555 (-3.7A)
None
 0.83A 5a06E-2fknA:
undetectable		 5a06E-2fknA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 7 LEU A 171
GLU A  40
GLY A 175
GLY A 176
 None
NAD  A5555 ( 4.8A)
NAD  A5555 (-3.7A)
None
 0.82A 5a06F-2fknA:
undetectable		 5a06F-2fknA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 7 ALA A 537
ASP A 521
ARG A 438
GLY A 355
 None
 0.76A 5bs8A-2fknA:
1.3
5bs8C-2fknA:
undetectable
5bs8D-2fknA:
undetectable		 5bs8A-2fknA:
22.41
5bs8C-2fknA:
22.41
5bs8D-2fknA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 7 ALA A 537
ASP A 521
ARG A 438
GLY A 355
 None
 0.93A 5btgA-2fknA:
1.3
5btgC-2fknA:
undetectable
5btgD-2fknA:
undetectable		 5btgA-2fknA:
22.41
5btgC-2fknA:
22.41
5btgD-2fknA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 8 SER A 132
GLY A 488
HIS A 497
ALA A 130
 None
 0.91A 5eevL-2fknA:
undetectable
5eevV-2fknA:
undetectable		 5eevL-2fknA:
9.42
5eevV-2fknA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 8 SER A 132
GLY A 488
HIS A 497
ALA A 130
 None
 0.91A 5eewL-2fknA:
undetectable
5eewV-2fknA:
undetectable		 5eewL-2fknA:
9.42
5eewV-2fknA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 12 ALA A 263
TYR A 270
LEU A 167
PHE A 309
GLY A 251
 None
NAD  A5555 (-3.6A)
None
None
None
 1.21A 5fsaA-2fknA:
0.7		 5fsaA-2fknA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_D_EVPD102_1
(DNA TOPOISOMERASE
2-ALPHA)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 4 GLY A 340
ASP A 318
ARG A 451
MET A 184
 None
None
NAD  A5555 (-4.1A)
None
 0.98A 5gwkB-2fknA:
0.6		 5gwkB-2fknA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 12 VAL A 501
ALA A  25
VAL A 435
LEU A 514
LEU A  71
 None
 1.20A 5hv1A-2fknA:
undetectable		 5hv1A-2fknA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 8 ASP A 521
PRO A 522
TYR A 411
PHE A 357
 None
 1.13A 5l1fA-2fknA:
undetectable
5l1fB-2fknA:
undetectable		 5l1fA-2fknA:
21.77
5l1fB-2fknA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 12 ILE A 436
GLY A 437
ASP A 442
LEU A 386
LEU A 409
 None
 1.22A 5nfjB-2fknA:
undetectable		 5nfjB-2fknA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 12 ILE A 436
GLY A 437
ASP A 442
LEU A 386
LEU A 409
 None
 1.21A 5nfjC-2fknA:
undetectable		 5nfjC-2fknA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 12 GLY A 176
GLY A 140
GLY A 137
GLY A 173
ILE A 406
 None
ACT  A 553 (-3.6A)
None
NAD  A5555 (-3.9A)
None
 0.94A 5wz2C-2fknA:
5.6		 5wz2C-2fknA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		3 / 3 VAL A 490
TYR A 494
GLU A 452
 None
 0.81A 5zmqD-2fknA:
undetectable
5zmqE-2fknA:
undetectable		 5zmqD-2fknA:
17.96
5zmqE-2fknA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		6 / 10 GLY A 170
GLY A 172
GLU A 193
VAL A 194
ASP A 195
THR A 261
 NAD  A5555 ( 4.0A)
NAD  A5555 (-3.3A)
NAD  A5555 (-2.8A)
NAD  A5555 (-4.4A)
None
NAD  A5555 (-4.4A)
 0.55A 6exiA-2fknA:
7.6		 6exiA-2fknA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		6 / 10 GLY A 170
GLY A 172
GLU A 193
VAL A 194
ASP A 195
THR A 261
 NAD  A5555 ( 4.0A)
NAD  A5555 (-3.3A)
NAD  A5555 (-2.8A)
NAD  A5555 (-4.4A)
None
NAD  A5555 (-4.4A)
 0.57A 6exiB-2fknA:
8.1		 6exiB-2fknA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		6 / 12 GLY A 170
GLY A 172
GLU A 193
VAL A 194
ASP A 195
THR A 261
 NAD  A5555 ( 4.0A)
NAD  A5555 (-3.3A)
NAD  A5555 (-2.8A)
NAD  A5555 (-4.4A)
None
NAD  A5555 (-4.4A)
 0.59A 6exiC-2fknA:
5.1
6exiD-2fknA:
8.0		 6exiC-2fknA:
9.83
6exiD-2fknA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		6 / 12 GLY A 170
GLY A 172
GLU A 193
VAL A 194
ASP A 195
THR A 261
 NAD  A5555 ( 4.0A)
NAD  A5555 (-3.3A)
NAD  A5555 (-2.8A)
NAD  A5555 (-4.4A)
None
NAD  A5555 (-4.4A)
 0.56A 6exiC-2fknA:
5.1
6exiD-2fknA:
7.9		 6exiC-2fknA:
9.83
6exiD-2fknA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 4 LYS A 396
LEU A 180
ALA A 393
LEU A 142
 None
 1.44A 6gnrA-2fknA:
undetectable		 6gnrA-2fknA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 4 LYS A 396
LEU A 180
ALA A 393
LEU A 142
 None
 1.42A 6gnrB-2fknA:
undetectable		 6gnrB-2fknA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		4 / 5 VAL A 503
PHE A  88
MET A  87
GLY A  86
 None
 1.23A 6hd4A-2fknA:
undetectable		 6hd4A-2fknA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 8 GLY A 175
VAL A 192
GLY A  50
SER A 262
ALA A 263
 NAD  A5555 (-3.7A)
None
NAD  A5555 (-3.5A)
NAD  A5555 (-2.9A)
None
 1.10A 6hu9H-2fknA:
undetectable
6hu9e-2fknA:
undetectable		 6hu9H-2fknA:
12.20
6hu9e-2fknA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 2fkn UROCANATE HYDRATASE
(Bacillus
subtilis) 		5 / 11 SER A 495
GLY A  52
GLY A 126
ASP A  44
ASP A 265
 None
 1.22A 6i5zD-2fknA:
5.0		 6i5zD-2fknA:
19.86