SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fko'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 7 ASP A  60
TRP A  38
PHE A  18
ARG A 170
 None
 1.49A 1b2iA-2fkoA:
undetectable		 1b2iA-2fkoA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 VAL A  58
VAL A  78
TRP A  38
 None
 0.75A 1bdwA-2fkoA:
undetectable
1bdwB-2fkoA:
undetectable		 1bdwA-2fkoA:
7.46
1bdwB-2fkoA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ALA A  89
ILE A  74
GLY A  75
GLY A  92
ILE A 103
 None
 0.79A 1hxbA-2fkoA:
undetectable		 1hxbA-2fkoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ASN A  83
ILE A  99
GLY A  98
GLY A  81
ASN A 155
 None
 0.99A 1liiA-2fkoA:
undetectable		 1liiA-2fkoA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ASN A  83
ILE A  99
GLY A  98
GLY A  81
ASN A 155
 None
 0.99A 1likA-2fkoA:
undetectable		 1likA-2fkoA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 GLY A  88
ALA A  84
ILE A  97
VAL A  52
ILE A  50
 None
 1.13A 3adsB-2fkoA:
undetectable		 3adsB-2fkoA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 GLY A  92
VAL A  86
ILE A  80
ILE A 114
VAL A 121
 None
 0.92A 3d1zA-2fkoA:
undetectable		 3d1zA-2fkoA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN
(Pyrococcus
horikoshii) 		4 / 6 ILE A  26
GLU A   5
LYS A   9
ASN A   7
 None
 1.49A 3kp6A-2fkoA:
undetectable
3kp6B-2fkoA:
undetectable		 3kp6A-2fkoA:
23.81
3kp6B-2fkoA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 ALA A  89
VAL A  86
ILE A  74
GLY A  92
ILE A 103
 None
 1.00A 3nu6A-2fkoA:
undetectable		 3nu6A-2fkoA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 ALA A  89
VAL A  86
ILE A  74
GLY A  92
ILE A 103
 None
 1.04A 3oxvB-2fkoA:
undetectable		 3oxvB-2fkoA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 ALA A  89
VAL A  86
ILE A  74
GLY A  92
ILE A 103
 None
 0.97A 3oxvD-2fkoA:
undetectable		 3oxvD-2fkoA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 ALA A  89
VAL A  86
ILE A  74
GLY A  92
ILE A 103
 None
 1.00A 3oxwB-2fkoA:
undetectable		 3oxwB-2fkoA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 10 VAL A  95
ALA A  84
VAL A  86
ILE A  80
ILE A 109
 None
 1.47A 3retA-2fkoA:
undetectable
3retB-2fkoA:
undetectable		 3retA-2fkoA:
19.21
3retB-2fkoA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 GLY A  88
ALA A  89
ILE A 109
VAL A 121
VAL A  91
 None
 0.82A 3ucbB-2fkoA:
undetectable		 3ucbB-2fkoA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 SER A 101
GLY A 118
ALA A 119
ILE A 115
ILE A  96
 None
 1.06A 4dt8A-2fkoA:
undetectable		 4dt8A-2fkoA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 ALA A  89
VAL A  86
ILE A  74
GLY A  92
ILE A 103
 None
 0.99A 4rvjA-2fkoA:
undetectable		 4rvjA-2fkoA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 11 ILE A  74
ILE A  80
VAL A  52
THR A  35
ALA A  41
 None
 1.02A 5lg3A-2fkoA:
undetectable		 5lg3A-2fkoA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ILE A  74
ILE A  80
VAL A  52
THR A  35
ALA A  41
 None
 1.03A 5lg3E-2fkoA:
undetectable		 5lg3E-2fkoA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ILE A  97
GLY A  98
ILE A  99
ILE A  64
ILE A  80
 None
 1.00A 6emuA-2fkoA:
undetectable		 6emuA-2fkoA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ILE A  97
GLY A  98
ILE A  99
ILE A  64
ILE A  80
 None
 1.02A 6emuB-2fkoA:
undetectable		 6emuB-2fkoA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN
(Pyrococcus
horikoshii) 		5 / 12 ILE A  97
GLY A  98
ILE A  99
ILE A  64
ILE A  80
 None
 1.00A 6emuC-2fkoA:
undetectable		 6emuC-2fkoA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN
(Pyrococcus
horikoshii) 		3 / 3 TRP A 151
GLU A 150
GLU A 157
 None
 0.94A 6fhwA-2fkoA:
undetectable		 6fhwA-2fkoA:
20.26