SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fkz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCB_P_DHIP3_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-L-GLN-D-PHE
-L-HIS-D-PRO-OH)		 2fkz BACTERIOFERRITIN
(Azotobacter
vinelandii) 		4 / 5 TYR A  32
TYR A  25
GLU A  44
GLN A  24
 None
 1.28A 1mcbA-2fkzA:
undetectable
1mcbB-2fkzA:
undetectable
1mcbP-2fkzA:
undetectable		 1mcbA-2fkzA:
14.03
1mcbB-2fkzA:
14.03
1mcbP-2fkzA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2fkz BACTERIOFERRITIN
(Azotobacter
vinelandii) 		4 / 6 ARG A  30
ILE A  49
PHE A  26
GLU A  47
 None
 1.49A 1nsiC-2fkzA:
undetectable
1nsiD-2fkzA:
undetectable		 1nsiC-2fkzA:
17.13
1nsiD-2fkzA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2fkz BACTERIOFERRITIN
(Azotobacter
vinelandii) 		4 / 6 PHE A  26
GLU A  47
ARG A  30
ILE A  49
 None
 1.50A 1nsiC-2fkzA:
undetectable
1nsiD-2fkzA:
undetectable		 1nsiC-2fkzA:
17.13
1nsiD-2fkzA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2fkz BACTERIOFERRITIN
(Azotobacter
vinelandii) 		6 / 11 GLU A  51
HIS A  54
LEU A  93
GLU A  94
ILE A 123
GLU A 127
 FE2  A1600 ( 2.5A)
FE2  A1600 (-3.1A)
None
FE2  A1601 (-1.8A)
FE2  A1600 ( 4.8A)
FE2  A1600 ( 2.5A)
 0.85A 1rnrA-2fkzA:
10.2		 1rnrA-2fkzA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2fkz BACTERIOFERRITIN
(Azotobacter
vinelandii) 		6 / 12 GLU A  51
HIS A  54
LEU A  93
GLU A  94
ILE A 123
GLU A 127
 FE2  A1600 ( 2.5A)
FE2  A1600 (-3.1A)
None
FE2  A1601 (-1.8A)
FE2  A1600 ( 4.8A)
FE2  A1600 ( 2.5A)
 0.89A 1rnrB-2fkzA:
10.1		 1rnrB-2fkzA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 2fkz BACTERIOFERRITIN
(Azotobacter
vinelandii) 		5 / 12 GLU A 109
ALA A 104
LEU A 101
VAL A   7
LEU A  11
 None
 1.11A 1sn5B-2fkzA:
undetectable
1sn5D-2fkzA:
undetectable		 1sn5B-2fkzA:
18.87
1sn5D-2fkzA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 2fkz BACTERIOFERRITIN
(Azotobacter
vinelandii) 		5 / 12 LEU A  11
GLU A 109
ALA A 104
LEU A 101
VAL A   7
 None
 1.12A 1sn5B-2fkzA:
undetectable
1sn5D-2fkzA:
undetectable		 1sn5B-2fkzA:
18.87
1sn5D-2fkzA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2fkz BACTERIOFERRITIN
(Azotobacter
vinelandii) 		4 / 7 ARG A  30
ILE A  49
PHE A  26
GLU A  47
 None
 1.48A 2nsiC-2fkzA:
undetectable
2nsiD-2fkzA:
undetectable		 2nsiC-2fkzA:
17.13
2nsiD-2fkzA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 2fkz BACTERIOFERRITIN
(Azotobacter
vinelandii) 		4 / 7 LYS A   5
ILE A   8
GLN A   9
LEU A 120
 None
 0.86A 3bjwF-2fkzA:
undetectable		 3bjwF-2fkzA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2fkz BACTERIOFERRITIN
(Azotobacter
vinelandii) 		4 / 8 SER A 116
ILE A   8
LEU A  11
GLY A  67
 None
 0.70A 3dcjB-2fkzA:
undetectable		 3dcjB-2fkzA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 2fkz BACTERIOFERRITIN
(Azotobacter
vinelandii) 		4 / 5 HIS A 130
LEU A  58
LEU A  19
ASP A  56
 FE2  A1601 ( 4.7A)
None
None
None
 1.29A 4aqlA-2fkzA:
undetectable		 4aqlA-2fkzA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2fkz BACTERIOFERRITIN
(Azotobacter
vinelandii) 		4 / 8 ASP A  90
HIS A  46
HIS A  28
GLU A  18
 None
None
None
FE2  A1600 (-2.4A)
 1.27A 6mn4B-2fkzA:
undetectable		 6mn4B-2fkzA:
23.17