SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fl3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 2fl3 R.HINP1I RESTRICTION
ENDONUCLEASE
(Haemophilus
influenzae) 		3 / 3 GLU A 230
ASN A 233
TRP A  98
 None
 1.29A 1r15D-2fl3A:
undetectable		 1r15D-2fl3A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 2fl3 R.HINP1I RESTRICTION
ENDONUCLEASE
(Haemophilus
influenzae) 		3 / 3 GLU A 230
ASN A 233
TRP A  98
 None
 1.30A 1r15E-2fl3A:
undetectable		 1r15E-2fl3A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 2fl3 R.HINP1I RESTRICTION
ENDONUCLEASE
(Haemophilus
influenzae) 		5 / 10 GLY A 211
PHE A 119
GLU A 140
LEU A 207
ILE A 213
 None
 1.23A 3kvrA-2fl3A:
undetectable		 3kvrA-2fl3A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 2fl3 R.HINP1I RESTRICTION
ENDONUCLEASE
(Haemophilus
influenzae) 		5 / 10 GLY A 211
PHE A 119
GLU A 140
LEU A 207
ILE A 213
 None
 1.27A 3kvrB-2fl3A:
undetectable		 3kvrB-2fl3A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2fl3 R.HINP1I RESTRICTION
ENDONUCLEASE
(Haemophilus
influenzae) 		3 / 3 HIS A 118
GLU A 145
ASN A 111
 None
 0.95A 4bupB-2fl3A:
undetectable		 4bupB-2fl3A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 2fl3 R.HINP1I RESTRICTION
ENDONUCLEASE
(Haemophilus
influenzae) 		4 / 6 LEU A 235
LEU A 116
ILE A 115
MET A 138
 None
 0.99A 4do3B-2fl3A:
undetectable		 4do3B-2fl3A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 2fl3 R.HINP1I RESTRICTION
ENDONUCLEASE
(Haemophilus
influenzae) 		4 / 4 TYR A 200
THR A 242
VAL A 178
ILE A 247
 None
 1.46A 4jx1F-2fl3A:
undetectable		 4jx1F-2fl3A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2fl3 R.HINP1I RESTRICTION
ENDONUCLEASE
(Haemophilus
influenzae) 		5 / 8 GLU A  47
HIS A  43
GLY A  42
ASP A  76
HIS A  78
 None
 1.38A 5f8yA-2fl3A:
undetectable		 5f8yA-2fl3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2fl3 R.HINP1I RESTRICTION
ENDONUCLEASE
(Haemophilus
influenzae) 		3 / 3 HIS A 118
GLU A 145
ASN A 111
 None
 0.92A 5wbvA-2fl3A:
undetectable		 5wbvA-2fl3A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2fl3 R.HINP1I RESTRICTION
ENDONUCLEASE
(Haemophilus
influenzae) 		3 / 3 HIS A 118
GLU A 145
ASN A 111
 None
 0.92A 5wbvB-2fl3A:
undetectable		 5wbvB-2fl3A:
22.67