SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fl5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LQT_B_ACTB1867_0 (FPRA)	2fl5	IMMUNOGLOBULIN IGG1 HEAVY CHAIN (Homo sapiens)	4 / 4	ALA H 88 ARG H 38 GLN H 39 GLU H 46	None	1.36A	1lqtB-2fl5H: undetectable	1lqtB-2fl5H: 18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LQU_B_ACTB1424_0 (FPRA)	2fl5	IMMUNOGLOBULIN IGG1 HEAVY CHAIN (Homo sapiens)	4 / 4	ALA H 88 ARG H 38 GLN H 39 GLU H 46	None	1.34A	1lquB-2fl5H: undetectable	1lquB-2fl5H: 18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UYU_A_CAMA1416_0 (CYTOCHROME P450-CAM)	2fl5	IMMUNOGLOBULIN IGG1 HEAVY CHAIN (Homo sapiens)	4 / 8	LEU H 20 THR H 49 VAL H 63 ASP H 86	None	1.17A	1uyuA-2fl5H: undetectable	1uyuA-2fl5H: 18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RCT_A_RTLA140_1 (RETINOL-BINDING PROTEIN II, CELLULAR)	2fl5	IMMUNOGLOBULIN IGG1 HEAVY CHAIN (Homo sapiens)	3 / 3	GLN H 82 THR H 107 TRP H 36	None	1.02A	2rctA-2fl5H: undetectable	2rctA-2fl5H: 19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y03_A_5FWA601_1 (BETA-1 ADRENERGIC RECEPTOR)	2fl5	IMMUNOGLOBULIN IGG1 HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 171 VAL H 191 SER H 189 ASN H 209 ASN H 162	None	1.39A	2y03A-2fl5H: undetectable	2y03A-2fl5H: 22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y03_B_5FWB601_1 (BETA-1 ADRENERGIC RECEPTOR)	2fl5	IMMUNOGLOBULIN IGG1 HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 171 VAL H 191 SER H 189 ASN H 209 ASN H 162	None	1.42A	2y03B-2fl5H: undetectable	2y03B-2fl5H: 22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QXV_C_MTXC2000_1 (ANTI-METHOTREXATE CDR1-4 GRAFT VHH)	2fl5	IMMUNOGLOBULIN IGG1 HEAVY CHAIN (Homo sapiens)	5 / 11	VAL H 2 ALA H 24 MET H 34 ARG H 71 ASN H 73	None	0.77A	3qxvC-2fl5H: 20.8	3qxvC-2fl5H: 35.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LDO_A_ALEA1402_1 (LYSOZYME, BETA-2 ADRENERGIC RECEPTOR)	2fl5	IMMUNOGLOBULIN IGG1 HEAVY CHAIN (Homo sapiens)	5 / 10	VAL H 171 VAL H 191 SER H 189 ASN H 209 ASN H 162	None	1.44A	4ldoA-2fl5H: undetectable	4ldoA-2fl5H: 20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H7M_B_68HB405_0 (BETA-1 ADRENERGIC RECEPTOR)	2fl5	IMMUNOGLOBULIN IGG1 HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 171 VAL H 191 SER H 189 ASN H 209 ASN H 162	None	1.40A	6h7mB-2fl5H: undetectable	6h7mB-2fl5H: 18.09

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1LQT_B_ACTB1867_0","FPRA","2fl5","IMMUNOGLOBULIN IGG1 HEAVY CHAIN","Homo sapiens",4,"ALA H  88;ARG H  38;GLN H  39;GLU H  46","None","1.36A","1lqtB-2fl5H:undetectable","1lqtB-2fl5H:18.49"],["1LQU_B_ACTB1424_0","FPRA","2fl5","IMMUNOGLOBULIN IGG1 HEAVY CHAIN","Homo sapiens",4,"ALA H  88;ARG H  38;GLN H  39;GLU H  46","None","1.34A","1lquB-2fl5H:undetectable","1lquB-2fl5H:18.49"],["1UYU_A_CAMA1416_0","CYTOCHROME P450-CAM","2fl5","IMMUNOGLOBULIN IGG1 HEAVY CHAIN","Homo sapiens",4,"LEU H  20;THR H  49;VAL H  63;ASP H  86","None","1.17A","1uyuA-2fl5H:undetectable","1uyuA-2fl5H:18.35"],["2RCT_A_RTLA140_1","RETINOL-BINDING PROTEIN II, CELLULAR","2fl5","IMMUNOGLOBULIN IGG1 HEAVY CHAIN","Homo sapiens",3,"GLN H  82;THR H 107;TRP H  36","None","1.02A","2rctA-2fl5H:undetectable","2rctA-2fl5H:19.82"],["2Y03_A_5FWA601_1","BETA-1 ADRENERGIC RECEPTOR","2fl5","IMMUNOGLOBULIN IGG1 HEAVY CHAIN","Homo sapiens",5,"VAL H 171;VAL H 191;SER H 189;ASN H 209;ASN H 162","None","1.39A","2y03A-2fl5H:undetectable","2y03A-2fl5H:22.01"],["2Y03_B_5FWB601_1","BETA-1 ADRENERGIC RECEPTOR","2fl5","IMMUNOGLOBULIN IGG1 HEAVY CHAIN","Homo sapiens",5,"VAL H 171;VAL H 191;SER H 189;ASN H 209;ASN H 162","None","1.42A","2y03B-2fl5H:undetectable","2y03B-2fl5H:22.01"],["3QXV_C_MTXC2000_1","ANTI-METHOTREXATE CDR1-4 GRAFT VHH","2fl5","IMMUNOGLOBULIN IGG1 HEAVY CHAIN","Homo sapiens",5,"VAL H   2;ALA H  24;MET H  34;ARG H  71;ASN H  73","None","0.77A","3qxvC-2fl5H:20.8","3qxvC-2fl5H:35.50"],["4LDO_A_ALEA1402_1","LYSOZYME, BETA-2 ADRENERGIC RECEPTOR","2fl5","IMMUNOGLOBULIN IGG1 HEAVY CHAIN","Homo sapiens",5,"VAL H 171;VAL H 191;SER H 189;ASN H 209;ASN H 162","None","1.44A","4ldoA-2fl5H:undetectable","4ldoA-2fl5H:20.39"],["6H7M_B_68HB405_0","BETA-1 ADRENERGIC RECEPTOR","2fl5","IMMUNOGLOBULIN IGG1 HEAVY CHAIN","Homo sapiens",5,"VAL H 171;VAL H 191;SER H 189;ASN H 209;ASN H 162","None","1.40A","6h7mB-2fl5H:undetectable","6h7mB-2fl5H:18.09"]]