SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fli'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2fli RIBULOSE-PHOSPHATE
3-EPIMERASE
(Streptococcus
pyogenes) 		4 / 5 VAL A 196
SER A   9
ASP A  86
GLN A 134
 None
DX5  A1901 (-2.7A)
None
None
 1.21A 1n2xB-2fliA:
undetectable		 1n2xB-2fliA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 2fli RIBULOSE-PHOSPHATE
3-EPIMERASE
(Streptococcus
pyogenes) 		5 / 12 ILE A  25
VAL A 208
SER A 209
GLU A  27
ALA A 204
 None
 1.17A 1sg9C-2fliA:
undetectable		 1sg9C-2fliA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 2fli RIBULOSE-PHOSPHATE
3-EPIMERASE
(Streptococcus
pyogenes) 		5 / 8 ALA A   7
ASP A  65
ILE A  25
ILE A  10
GLY A 198
 None
None
None
None
DX5  A1901 (-3.4A)
 1.26A 1sh9A-2fliA:
undetectable		 1sh9A-2fliA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0F_A_STRA1499_1
(CYTOCHROME P450 3A4)		 2fli RIBULOSE-PHOSPHATE
3-EPIMERASE
(Streptococcus
pyogenes) 		4 / 4 PHE A  80
ASP A  86
PHE A  64
VAL A  53
 None
 1.10A 1w0fA-2fliA:
0.0		 1w0fA-2fliA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 2fli RIBULOSE-PHOSPHATE
3-EPIMERASE
(Streptococcus
pyogenes) 		5 / 12 ILE A 137
PHE A 171
LEU A 129
LEU A 128
VAL A 114
 None
 1.20A 2bxfA-2fliA:
undetectable		 2bxfA-2fliA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 2fli RIBULOSE-PHOSPHATE
3-EPIMERASE
(Streptococcus
pyogenes) 		4 / 7 ILE A 116
PRO A  73
LEU A 102
ILE A  90
 None
 0.83A 2q83A-2fliA:
undetectable		 2q83A-2fliA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 2fli RIBULOSE-PHOSPHATE
3-EPIMERASE
(Streptococcus
pyogenes) 		4 / 6 ILE A 116
PRO A  73
LEU A 102
ILE A  90
 None
 0.93A 2q83B-2fliA:
undetectable		 2q83B-2fliA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 2fli RIBULOSE-PHOSPHATE
3-EPIMERASE
(Streptococcus
pyogenes) 		5 / 11 THR A  92
VAL A 132
SER A 170
ILE A 173
ALA A 122
 None
 1.24A 2zbzA-2fliA:
undetectable		 2zbzA-2fliA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2fli RIBULOSE-PHOSPHATE
3-EPIMERASE
(Streptococcus
pyogenes) 		5 / 12 ASP A 176
THR A 213
PRO A   8
GLY A 198
LEU A 201
 DX5  A1901 ( 2.6A)
None
None
DX5  A1901 (-3.4A)
None
 1.06A 3j6pB-2fliA:
3.1		 3j6pB-2fliA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 2fli RIBULOSE-PHOSPHATE
3-EPIMERASE
(Streptococcus
pyogenes) 		5 / 10 PHE A  42
GLY A 143
VAL A  71
ASN A  45
GLY A  40
 None
DX5  A1901 (-3.6A)
None
None
None
 1.26A 3km6A-2fliA:
undetectable		 3km6A-2fliA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 2fli RIBULOSE-PHOSPHATE
3-EPIMERASE
(Streptococcus
pyogenes) 		5 / 9 PHE A  42
GLY A 143
VAL A  71
ASN A  45
GLY A  40
 None
DX5  A1901 (-3.6A)
None
None
None
 1.27A 3kmoA-2fliA:
undetectable		 3kmoA-2fliA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 2fli RIBULOSE-PHOSPHATE
3-EPIMERASE
(Streptococcus
pyogenes) 		3 / 3 HIS A  67
HIS A  91
MET A  69
 ZN  A1981 ( 3.3A)
None
DX5  A1901 (-3.4A)
 0.64A 3mihA-2fliA:
undetectable		 3mihA-2fliA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2fli RIBULOSE-PHOSPHATE
3-EPIMERASE
(Streptococcus
pyogenes) 		3 / 3 ILE A  37
MET A  56
ARG A  57
 None
 0.86A 4lnwA-2fliA:
undetectable		 4lnwA-2fliA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2fli RIBULOSE-PHOSPHATE
3-EPIMERASE
(Streptococcus
pyogenes) 		3 / 3 ILE A  37
MET A  56
ARG A  57
 None
 0.87A 4lnxA-2fliA:
undetectable		 4lnxA-2fliA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 2fli RIBULOSE-PHOSPHATE
3-EPIMERASE
(Streptococcus
pyogenes) 		5 / 12 SER A  47
GLY A  49
VAL A  52
PHE A  80
LEU A  68
 None
 1.36A 5jo9A-2fliA:
undetectable		 5jo9A-2fliA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2fli RIBULOSE-PHOSPHATE
3-EPIMERASE
(Streptococcus
pyogenes) 		5 / 12 ASP A 176
THR A 213
PRO A   8
GLY A 198
LEU A 201
 DX5  A1901 ( 2.6A)
None
None
DX5  A1901 (-3.4A)
None
 0.97A 5ogcB-2fliA:
3.1		 5ogcB-2fliA:
20.18