SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2flq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		4 / 7 HIS A 307
HIS A 308
THR A 343
THR A 344
 None
 1.05A 1am6A-2flqA:
undetectable		 1am6A-2flqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		5 / 9 LEU A 213
ILE A 202
LEU A 263
GLY A 250
ALA A 292
 None
 1.11A 1e7aA-2flqA:
2.4		 1e7aA-2flqA:
19.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		4 / 6 GLY A  78
TRP A 243
VAL A 305
ALA A 310
 HEM  A 901 ( 4.3A)
HEM  A 901 ( 3.5A)
None
None
 0.39A 1p6kA-2flqA:
48.2		 1p6kA-2flqA:
42.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		3 / 3 TRP A  82
ARG A  79
PHE A 317
 None
 0.97A 1zeaH-2flqA:
undetectable
1zeaL-2flqA:
undetectable		 1zeaH-2flqA:
20.79
1zeaL-2flqA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		4 / 8 GLU A  60
ILE A  24
LYS A  33
GLU A  37
 None
 0.83A 2j9dJ-2flqA:
0.0
2j9dK-2flqA:
undetectable
2j9dL-2flqA:
undetectable		 2j9dJ-2flqA:
13.76
2j9dK-2flqA:
13.76
2j9dL-2flqA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		4 / 8 ILE A  24
LYS A  33
GLU A  37
GLU A  60
 None
 0.78A 2j9dJ-2flqA:
0.0
2j9dK-2flqA:
undetectable
2j9dL-2flqA:
undetectable		 2j9dJ-2flqA:
13.76
2j9dK-2flqA:
13.76
2j9dL-2flqA:
13.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLY A  78
TRP A 243
VAL A 305
 HEM  A 901 ( 4.3A)
HEM  A 901 ( 3.5A)
None
 0.24A 3n62B-2flqA:
48.2		 3n62B-2flqA:
42.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLY A  78
TRP A 243
VAL A 305
 HEM  A 901 ( 4.3A)
HEM  A 901 ( 3.5A)
None
 0.25A 3n65B-2flqA:
48.1		 3n65B-2flqA:
42.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLY A  78
TRP A 243
VAL A 305
 HEM  A 901 ( 4.3A)
HEM  A 901 ( 3.5A)
None
 0.25A 3n66B-2flqA:
16.3		 3n66B-2flqA:
42.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 155
ASP A 151
ALA A 140
TYR A 142
 None
 1.09A 3rodD-2flqA:
undetectable		 3rodD-2flqA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		3 / 3 HIS A 134
SER A 152
ASN A 253
 None
None
ARG  A 376 (-2.9A)
 0.87A 3s8pB-2flqA:
undetectable		 3s8pB-2flqA:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 252
THR A 333
TRP A 334
 None
 0.16A 4d7hA-2flqA:
46.6		 4d7hA-2flqA:
63.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		5 / 6 ARG A 138
GLU A 248
ARG A 252
ASP A 256
ARG A 259
 ARG  A 376 (-3.6A)
ARG  A 376 ( 2.9A)
None
None
None
 0.72A 4kcnA-2flqA:
47.9		 4kcnA-2flqA:
42.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		5 / 6 ARG A 138
GLU A 248
ARG A 252
ASP A 256
ARG A 259
 ARG  A 376 (-3.6A)
ARG  A 376 ( 2.9A)
None
None
None
 0.70A 4kcnB-2flqA:
47.9		 4kcnB-2flqA:
42.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXX_A_CHDA302_0
(CARBONIC ANHYDRASE 2)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		5 / 9 GLU A 248
HIS A 307
HIS A 308
THR A 343
THR A 344
 ARG  A 376 ( 2.9A)
None
None
None
None
 1.03A 4pxxA-2flqA:
undetectable		 4pxxA-2flqA:
19.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 252
THR A 333
TRP A 334
 None
 0.20A 4ug5A-2flqA:
51.7		 4ug5A-2flqA:
63.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 252
THR A 333
TRP A 334
 None
 0.22A 4uglA-2flqA:
51.9		 4uglA-2flqA:
63.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 365
ASP A 225
TYR A 362
 None
None
HEM  A 901 (-4.3A)
 0.81A 4yo9B-2flqA:
undetectable		 4yo9B-2flqA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		3 / 3 HIS A 134
SER A 152
ASN A 253
 None
None
ARG  A 376 (-2.9A)
 0.89A 5cprB-2flqA:
undetectable		 5cprB-2flqA:
20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 252
THR A 333
TRP A 334
 None
 0.17A 5g6cA-2flqA:
46.8		 5g6cA-2flqA:
63.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLY A  78
TRP A 243
VAL A 305
 HEM  A 901 ( 4.3A)
HEM  A 901 ( 3.5A)
None
 0.22A 5vuoB-2flqA:
48.1		 5vuoB-2flqA:
42.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		4 / 6 GLY A 150
ASP A 151
SER A 153
ARG A 259
 None
 1.19A 6dwdA-2flqA:
undetectable
6dwdC-2flqA:
undetectable		 6dwdA-2flqA:
22.04
6dwdC-2flqA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		4 / 4 ASP A 331
ILE A 336
PRO A 337
LEU A 335
 None
 1.29A 6mkeB-2flqA:
undetectable		 6mkeB-2flqA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2flq NITRIC OXIDE
SYNTHASE
(Geobacillus
stearothermophil
us) 		4 / 4 ASP A 331
ILE A 336
PRO A 337
LEU A 335
 None
 1.23A 6mkeA-2flqA:
undetectable		 6mkeA-2flqA:
9.89