SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2flz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 2flz CIS-3-CHLOROACRYLIC
ACID DEHALOGENASE
(coryneform
bacterium) 		5 / 11 GLY A  33
THR A  32
HIS A  28
LEU A 119
GLY A 123
 None
SO4  A1001 ( 4.5A)
SO4  A1001 (-3.9A)
None
None
 1.05A 1i7qA-2flzA:
undetectable		 1i7qA-2flzA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2flz CIS-3-CHLOROACRYLIC
ACID DEHALOGENASE
(coryneform
bacterium) 		5 / 12 VAL A  86
ALA A  92
ALA A  93
ALA A  19
VAL A 102
 None
 0.88A 3fc6C-2flzA:
undetectable		 3fc6C-2flzA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2flz CIS-3-CHLOROACRYLIC
ACID DEHALOGENASE
(coryneform
bacterium) 		5 / 12 VAL A  86
ALA A  92
ALA A  93
LEU A  12
ALA A  19
 None
 0.96A 3fc6C-2flzA:
undetectable		 3fc6C-2flzA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2flz CIS-3-CHLOROACRYLIC
ACID DEHALOGENASE
(coryneform
bacterium) 		4 / 6 PHE A  43
ALA A  21
THR A  25
ALA A  39
 None
 1.07A 3mdrB-2flzA:
undetectable		 3mdrB-2flzA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 2flz CIS-3-CHLOROACRYLIC
ACID DEHALOGENASE
(coryneform
bacterium) 		4 / 7 VAL A   7
PHE A  43
VAL A  41
ILE A 100
 None
 0.97A 3zjqA-2flzA:
undetectable		 3zjqA-2flzA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 2flz CIS-3-CHLOROACRYLIC
ACID DEHALOGENASE
(coryneform
bacterium) 		4 / 7 VAL A   7
PHE A  43
VAL A  41
ILE A 100
 None
 0.95A 3zjqB-2flzA:
undetectable		 3zjqB-2flzA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2flz CIS-3-CHLOROACRYLIC
ACID DEHALOGENASE
(coryneform
bacterium) 		4 / 4 VAL A  65
VAL A   5
TYR A   3
GLN A  40
 None
 1.48A 5qgoA-2flzA:
undetectable		 5qgoA-2flzA:
21.86