SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fm4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 2fm4 PYRUVATE, PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		4 / 6 VAL A 448
THR A 447
LEU A 429
ARG A 428
 None
 0.99A 1s8fB-2fm4A:
undetectable		 1s8fB-2fm4A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 2fm4 PYRUVATE, PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 12 GLY A 470
GLY A 450
VAL A 448
THR A 447
LEU A 446
 None
 1.20A 4f84A-2fm4A:
undetectable		 4f84A-2fm4A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2fm4 PYRUVATE, PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 9 VAL A 427
LEU A 446
GLY A 472
LEU A 485
CYH A 471
 None
 1.33A 6czmD-2fm4A:
undetectable
6czmE-2fm4A:
undetectable		 6czmD-2fm4A:
17.20
6czmE-2fm4A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2fm4 PYRUVATE, PHOSPHATE
DIKINASE
([Clostridium]
symbiosum) 		5 / 10 VAL A 427
LEU A 446
GLY A 472
LEU A 485
CYH A 471
 None
 1.32A 6czmE-2fm4A:
undetectable
6czmF-2fm4A:
undetectable		 6czmE-2fm4A:
17.20
6czmF-2fm4A:
17.20