SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fm8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 2fm8 CELL INVASION
PROTEIN SIPA
(Salmonella
enterica) 		4 / 7 TYR C 186
GLU C 144
PHE C 258
ARG C 255
 None
 1.37A 1b2iA-2fm8C:
undetectable		 1b2iA-2fm8C:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2fm8 CELL INVASION
PROTEIN SIPA
(Salmonella
enterica) 		4 / 7 GLU C 156
LEU C 152
LEU C 142
GLY C 139
 None
 0.91A 1mt1H-2fm8C:
undetectable
1mt1K-2fm8C:
undetectable		 1mt1H-2fm8C:
23.81
1mt1K-2fm8C:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 2fm8 CELL INVASION
PROTEIN SIPA
SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAK
(Salmonella
enterica) 		4 / 6 LEU A 119
ASN A 120
LEU A  40
LEU C  31
 None
 0.97A 1z95A-2fm8A:
undetectable		 1z95A-2fm8A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 2fm8 CELL INVASION
PROTEIN SIPA
(Salmonella
enterica) 		5 / 9 PHE C  67
GLY C  70
ILE C 128
ALA C  75
VAL C  79
 None
 1.34A 2drdA-2fm8C:
undetectable		 2drdA-2fm8C:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2001_1
(SERUM ALBUMIN)		 2fm8 CELL INVASION
PROTEIN SIPA
SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAK
(Salmonella
enterica) 		5 / 12 LEU C  31
PHE A 115
ILE A  24
ARG C  35
GLY A  26
 None
 1.17A 2vufA-2fm8C:
4.3		 2vufA-2fm8C:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 2fm8 CELL INVASION
PROTEIN SIPA
SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAK
(Salmonella
enterica) 		4 / 6 LEU A 119
TYR A 123
LEU A 126
LEU C  27
 None
 0.95A 3f33A-2fm8A:
undetectable		 3f33A-2fm8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2fm8 CELL INVASION
PROTEIN SIPA
(Salmonella
enterica) 		4 / 4 LEU C 252
PRO C 251
LEU C  98
ARG C 100
 None
 1.18A 3hcoB-2fm8C:
undetectable		 3hcoB-2fm8C:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2fm8 CELL INVASION
PROTEIN SIPA
(Salmonella
enterica) 		4 / 6 ILE C 187
VAL C 183
LEU C 155
LEU C 152
 None
 0.93A 3kp6A-2fm8C:
undetectable
3kp6B-2fm8C:
undetectable		 3kp6A-2fm8C:
23.50
3kp6B-2fm8C:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 2fm8 CELL INVASION
PROTEIN SIPA
(Salmonella
enterica) 		5 / 12 LEU C 103
ALA C 102
LEU C 253
LEU C 252
LEU C 229
 None
 1.07A 4dm8B-2fm8C:
undetectable		 4dm8B-2fm8C:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 2fm8 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAK
(Salmonella
enterica) 		5 / 12 ILE A  54
LEU A 119
VAL A  10
LEU A  35
ILE A  24
 None
 1.15A 4g1bD-2fm8A:
undetectable		 4g1bD-2fm8A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2fm8 CELL INVASION
PROTEIN SIPA
(Salmonella
enterica) 		5 / 12 ALA C 105
ALA C 102
LEU C 249
ILE C 250
LEU C 244
 None
 1.00A 4k6iA-2fm8C:
undetectable		 4k6iA-2fm8C:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 2fm8 CELL INVASION
PROTEIN SIPA
SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAK
(Salmonella
enterica) 		5 / 12 ILE A  54
ARG A  11
LEU C  31
LEU C  27
ILE A  43
 None
 1.08A 4m2xE-2fm8A:
undetectable		 4m2xE-2fm8A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2fm8 CELL INVASION
PROTEIN SIPA
(Salmonella
enterica) 		4 / 4 ASN C  85
GLY C  88
ASP C  72
ASP C 130
 None
 1.28A 4n49A-2fm8C:
undetectable		 4n49A-2fm8C:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 2fm8 CELL INVASION
PROTEIN SIPA
SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAK
(Salmonella
enterica) 		4 / 7 LEU A 119
ASN A 120
LEU A  40
LEU C  31
 None
 1.00A 4okwA-2fm8A:
undetectable		 4okwA-2fm8A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 2fm8 CELL INVASION
PROTEIN SIPA
(Salmonella
enterica) 		5 / 12 ILE C 163
VAL C 257
LEU C 222
LEU C 152
LEU C 155
 None
 1.17A 4qzuC-2fm8C:
undetectable		 4qzuC-2fm8C:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 2fm8 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAK
(Salmonella
enterica) 		4 / 5 ILE A   6
ILE A  27
ARG A  11
GLU A   8
 None
 1.28A 4zzcE-2fm8A:
undetectable		 4zzcE-2fm8A:
20.48