SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fmd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2fmd LECTIN
(Leucomphalos
mildbraedii) 		5 / 12 ALA A  67
THR A  71
PHE A  90
ILE A  92
PHE A  69
 None
 1.22A 2v95A-2fmdA:
undetectable		 2v95A-2fmdA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2fmd LECTIN
(Leucomphalos
mildbraedii) 		4 / 6 HIS A 143
VAL A 182
ILE A 151
LEU A 180
 MN  A 302 (-3.6A)
None
None
None
 0.91A 3kk6A-2fmdA:
undetectable		 3kk6A-2fmdA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 2fmd LECTIN
(Leucomphalos
mildbraedii) 		4 / 8 PHE A 128
ALA A 214
ASN A 223
PHE A  75
 None
 0.91A 3t3sF-2fmdA:
undetectable		 3t3sF-2fmdA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2fmd LECTIN
(Leucomphalos
mildbraedii) 		4 / 6 PHE A  20
ALA A  24
GLY A  27
LEU A  32
 None
 0.94A 4dubA-2fmdA:
undetectable		 4dubA-2fmdA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 2fmd LECTIN
(Leucomphalos
mildbraedii) 		4 / 7 ILE A  57
PHE A 230
VAL A 208
ILE A  92
 None
 1.01A 4zzbC-2fmdA:
undetectable
4zzbD-2fmdA:
undetectable		 4zzbC-2fmdA:
22.56
4zzbD-2fmdA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2fmd LECTIN
(Leucomphalos
mildbraedii) 		4 / 7 ALA A  85
GLY A 217
GLY A  45
THR A 130
 MAN  A 241 (-3.2A)
MAN  A 241 (-3.1A)
None
None
 0.69A 5ybbB-2fmdA:
undetectable		 5ybbB-2fmdA:
18.44