SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 2fml MUTT/NUDIX FAMILY
PROTEIN
(Enterococcus
faecalis) 		4 / 7 PHE A 248
PRO A 205
ALA A 220
PHE A 215
 None
 1.25A 1lqtA-2fmlA:
undetectable		 1lqtA-2fmlA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 2fml MUTT/NUDIX FAMILY
PROTEIN
(Enterococcus
faecalis) 		4 / 7 PHE A 248
PRO A 205
ALA A 220
PHE A 215
 None
 1.24A 1lquA-2fmlA:
undetectable		 1lquA-2fmlA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2fml MUTT/NUDIX FAMILY
PROTEIN
(Enterococcus
faecalis) 		4 / 7 ILE A 158
LEU A 151
THR A 181
LEU A 182
 None
 0.94A 1v55A-2fmlA:
undetectable
1v55J-2fmlA:
undetectable		 1v55A-2fmlA:
16.86
1v55J-2fmlA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 2fml MUTT/NUDIX FAMILY
PROTEIN
(Enterococcus
faecalis) 		3 / 3 ARG A 117
GLU A  36
SER A 111
 GOL  A 301 (-2.8A)
None
None
 0.87A 2xkkA-2fmlA:
undetectable
2xkkC-2fmlA:
3.9		 2xkkA-2fmlA:
16.88
2xkkC-2fmlA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fml MUTT/NUDIX FAMILY
PROTEIN
(Enterococcus
faecalis) 		4 / 7 LEU A 267
PHE A 215
LEU A 208
PHE A 131
 None
 1.03A 3ag2C-2fmlA:
undetectable		 3ag2C-2fmlA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 2fml MUTT/NUDIX FAMILY
PROTEIN
(Enterococcus
faecalis) 		4 / 7 SER A  88
ASP A  87
THR A  93
SER A  84
 None
 0.92A 4ac9C-2fmlA:
undetectable		 4ac9C-2fmlA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2fml MUTT/NUDIX FAMILY
PROTEIN
(Enterococcus
faecalis) 		5 / 12 VAL A  58
LEU A 171
ILE A 158
LEU A 160
VAL A 198
 None
 1.13A 4y0qA-2fmlA:
undetectable		 4y0qA-2fmlA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 2fml MUTT/NUDIX FAMILY
PROTEIN
(Enterococcus
faecalis) 		3 / 3 LYS A  64
ARG A  69
HIS A  66
 None
 1.22A 4zbrA-2fmlA:
undetectable		 4zbrA-2fmlA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 2fml MUTT/NUDIX FAMILY
PROTEIN
(Enterococcus
faecalis) 		3 / 3 ARG A 153
PHE A 149
LEU A  47
 None
 0.55A 5veuA-2fmlA:
undetectable		 5veuA-2fmlA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2fml MUTT/NUDIX FAMILY
PROTEIN
(Enterococcus
faecalis) 		3 / 3 ARG A  63
PHE A  78
ARG A 120
 None
None
GOL  A 301 ( 4.8A)
 0.95A 5y9yA-2fmlA:
undetectable		 5y9yA-2fmlA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2fml MUTT/NUDIX FAMILY
PROTEIN
(Enterococcus
faecalis) 		4 / 8 ARG A 153
PHE A 227
ASN A 195
ASP A 199
 None
 1.01A 6auuB-2fmlA:
undetectable		 6auuB-2fmlA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2fml MUTT/NUDIX FAMILY
PROTEIN
(Enterococcus
faecalis) 		5 / 12 LEU A  60
ASP A 180
LEU A 182
PRO A  67
GLY A  65
 None
 1.16A 6b0lB-2fmlA:
undetectable		 6b0lB-2fmlA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2fml MUTT/NUDIX FAMILY
PROTEIN
(Enterococcus
faecalis) 		4 / 5 ILE A 158
LEU A 151
THR A 181
LEU A 182
 None
 0.89A 6nmpN-2fmlA:
undetectable
6nmpW-2fmlA:
undetectable		 6nmpN-2fmlA:
16.86
6nmpW-2fmlA:
13.96