SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fmt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		4 / 4 THR A 163
LEU A 167
LEU A 174
GLN A 177
 None
 1.21A 1fbmA-2fmtA:
undetectable		 1fbmA-2fmtA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A  23
LEU A  60
ILE A 180
LEU A  80
VAL A  86
 None
 1.20A 1hrkA-2fmtA:
2.7		 1hrkA-2fmtA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		4 / 7 PHE A 307
VAL A 247
VAL A 274
ILE A 272
 None
 0.98A 1p7rA-2fmtA:
undetectable		 1p7rA-2fmtA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		4 / 4 LEU A 286
PRO A 234
ILE A 214
LEU A 238
 None
 1.12A 1ya4C-2fmtA:
undetectable		 1ya4C-2fmtA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A  23
LEU A  60
ILE A 180
LEU A  80
VAL A  86
 None
 1.22A 2hrcA-2fmtA:
undetectable		 2hrcA-2fmtA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A  23
LEU A  60
ILE A 180
LEU A  80
VAL A  86
 None
 1.21A 2hrcB-2fmtA:
2.4		 2hrcB-2fmtA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		5 / 10 ILE A 240
LEU A 299
VAL A 245
VAL A 274
ILE A 272
 None
 1.03A 2nnjA-2fmtA:
undetectable		 2nnjA-2fmtA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		4 / 8 LEU A 183
LEU A  23
VAL A  32
GLY A  31
 None
 0.92A 2po5B-2fmtA:
2.5		 2po5B-2fmtA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		5 / 8 ALA A 191
LEU A 186
LEU A 183
ILE A 138
VAL A  86
 None
 1.27A 2uxpA-2fmtA:
undetectable		 2uxpA-2fmtA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		5 / 8 LEU A 286
LEU A 283
ILE A 214
VAL A 274
ILE A 264
 None
 1.27A 2uxpA-2fmtA:
undetectable		 2uxpA-2fmtA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		5 / 12 ALA A  21
LEU A  23
LEU A  60
GLY A 175
PRO A 176
 None
 1.07A 3ozwB-2fmtA:
4.0		 3ozwB-2fmtA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		5 / 12 THR A 159
ARG A 228
GLY A 165
ALA A 129
GLY A 130
 None
 1.00A 3v3oA-2fmtA:
4.7		 3v3oA-2fmtA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		4 / 5 VAL A  98
LEU A  94
LEU A  68
ILE A   7
 None
 0.95A 4a9jB-2fmtA:
undetectable		 4a9jB-2fmtA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		5 / 12 PHE A   8
ALA A  21
LEU A  22
VAL A  88
ILE A 138
 None
 1.03A 4g1bA-2fmtA:
5.0		 4g1bA-2fmtA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		5 / 11 HIS A  27
THR A 182
ARG A 103
GLY A 189
ALA A 187
 None
 1.44A 4qvmV-2fmtA:
undetectable
4qvmb-2fmtA:
undetectable		 4qvmV-2fmtA:
21.45
4qvmb-2fmtA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		5 / 11 HIS A  27
THR A 182
ARG A 103
GLY A 189
ALA A 187
 None
 1.44A 4qvqV-2fmtA:
undetectable
4qvqb-2fmtA:
undetectable		 4qvqV-2fmtA:
21.45
4qvqb-2fmtA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		5 / 11 HIS A  27
THR A 182
ARG A 103
GLY A 189
ALA A 187
 None
 1.43A 4qvqH-2fmtA:
undetectable
4qvqN-2fmtA:
undetectable		 4qvqH-2fmtA:
21.45
4qvqN-2fmtA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		5 / 11 HIS A  27
THR A 182
ARG A 103
GLY A 189
ALA A 187
 None
 1.45A 4qw0V-2fmtA:
undetectable
4qw0b-2fmtA:
undetectable		 4qw0V-2fmtA:
21.45
4qw0b-2fmtA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		5 / 11 HIS A  27
THR A 182
ARG A 103
GLY A 189
ALA A 187
 None
 1.45A 4qw0H-2fmtA:
undetectable
4qw0N-2fmtA:
undetectable		 4qw0H-2fmtA:
21.45
4qw0N-2fmtA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		5 / 11 HIS A  27
THR A 182
ARG A 103
GLY A 189
ALA A 187
 None
 1.45A 4qw1V-2fmtA:
undetectable
4qw1b-2fmtA:
undetectable		 4qw1V-2fmtA:
21.45
4qw1b-2fmtA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		5 / 11 HIS A  27
THR A 182
ARG A 103
GLY A 189
ALA A 187
 None
 1.44A 4qw1H-2fmtA:
undetectable
4qw1N-2fmtA:
undetectable		 4qw1H-2fmtA:
21.45
4qw1N-2fmtA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		4 / 7 THR A 181
GLY A 178
THR A 182
VAL A 136
 None
 0.76A 4qwpB-2fmtA:
undetectable		 4qwpB-2fmtA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		4 / 7 CYH A 106
ILE A 107
PRO A 102
ILE A   7
 None
 1.04A 4w5oA-2fmtA:
3.5		 4w5oA-2fmtA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		4 / 7 CYH A 106
ILE A 107
PRO A 102
ILE A   7
 None
 1.02A 4z4eA-2fmtA:
3.5		 4z4eA-2fmtA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		4 / 7 CYH A 106
ILE A 107
PRO A 102
ILE A   7
 None
 1.03A 4z4gA-2fmtA:
2.5		 4z4gA-2fmtA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		4 / 7 ASP A 162
THR A 159
PRO A 157
THR A 134
 None
 1.34A 5b6iA-2fmtA:
2.1		 5b6iA-2fmtA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		5 / 11 HIS A  27
THR A 182
ARG A 103
GLY A 189
ALA A 187
 None
 1.44A 5cz7H-2fmtA:
undetectable
5cz7N-2fmtA:
undetectable		 5cz7H-2fmtA:
21.45
5cz7N-2fmtA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		5 / 11 HIS A  27
THR A 182
ARG A 103
GLY A 189
ALA A 187
 None
 1.46A 5l66V-2fmtA:
undetectable
5l66b-2fmtA:
undetectable		 5l66V-2fmtA:
21.45
5l66b-2fmtA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		5 / 11 HIS A  27
THR A 182
ARG A 103
GLY A 189
ALA A 187
 None
 1.46A 5l66H-2fmtA:
undetectable
5l66N-2fmtA:
undetectable		 5l66H-2fmtA:
21.45
5l66N-2fmtA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		4 / 4 GLU A 266
PRO A 309
ILE A 264
LEU A 265
 None
 1.16A 5m45A-2fmtA:
undetectable		 5m45A-2fmtA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		4 / 4 GLU A 266
PRO A 309
ILE A 264
LEU A 265
 None
 1.20A 5m45D-2fmtA:
undetectable		 5m45D-2fmtA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		4 / 4 GLU A 266
PRO A 309
ILE A 264
LEU A 265
 None
 1.15A 5m45G-2fmtA:
undetectable		 5m45G-2fmtA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		4 / 4 GLU A 266
PRO A 309
ILE A 264
LEU A 265
 None
 1.19A 5m45J-2fmtA:
undetectable		 5m45J-2fmtA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		4 / 7 GLN A 140
LEU A 104
ASP A  83
LEU A  80
 None
 0.86A 5nwvA-2fmtA:
undetectable		 5nwvA-2fmtA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		4 / 7 THR A 276
LEU A 286
GLN A 243
GLU A 241
 None
 0.97A 5tudA-2fmtA:
undetectable		 5tudA-2fmtA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE
(Escherichia
coli) 		4 / 7 GLN A 124
GLY A 165
GLN A 287
ASP A  13
 None
None
G  C  70 ( 4.0A)
None
 1.11A 5vlmE-2fmtA:
undetectable		 5vlmE-2fmtA:
21.56