SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fn4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 2fn4 RAS-RELATED PROTEIN
R-RAS
(Homo
sapiens) 		3 / 3 PHE A  54
LEU A  45
SER A 172
 GDP  A   1 ( 4.9A)
None
GDP  A   1 (-3.5A)
 0.75A 1e7aA-2fn4A:
1.3		 1e7aA-2fn4A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2fn4 RAS-RELATED PROTEIN
R-RAS
(Homo
sapiens) 		3 / 3 GLU A  63
LEU A  82
LEU A  45
 None
 0.75A 3ohtA-2fn4A:
undetectable		 3ohtA-2fn4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2fn4 RAS-RELATED PROTEIN
R-RAS
(Homo
sapiens) 		3 / 3 GLU A  63
LEU A  82
LEU A 106
 None
 0.65A 3ohtA-2fn4A:
undetectable		 3ohtA-2fn4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2fn4 RAS-RELATED PROTEIN
R-RAS
(Homo
sapiens) 		3 / 3 GLU A  63
LEU A  82
LEU A  45
 None
 0.77A 3ohtB-2fn4A:
undetectable		 3ohtB-2fn4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2fn4 RAS-RELATED PROTEIN
R-RAS
(Homo
sapiens) 		3 / 3 GLU A  63
LEU A  82
LEU A 106
 None
 0.65A 3ohtB-2fn4A:
undetectable		 3ohtB-2fn4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 2fn4 RAS-RELATED PROTEIN
R-RAS
(Homo
sapiens) 		3 / 3 LEU A 105
VAL A 179
ASP A 180
 None
 0.58A 5x23A-2fn4A:
undetectable		 5x23A-2fn4A:
15.64