SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fn9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 8 LEU A 136
ARG A 148
PHE A 152
GLY A 110
 None
 0.82A 1fapB-2fn9A:
undetectable		 1fapB-2fn9A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 PHE A  86
PHE A  63
THR A  43
ILE A  72
ALA A  78
 None
 1.50A 1fm4A-2fn9A:
undetectable		 1fm4A-2fn9A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 138
ALA A 177
GLY A 221
ALA A 205
ILE A 219
 None
 0.98A 1gtnL-2fn9A:
undetectable
1gtnV-2fn9A:
undetectable		 1gtnL-2fn9A:
16.13
1gtnV-2fn9A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGL_L_ESTL911_1
(IG GAMMA-1-CHAIN
IG KAPPA-CHAIN)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 10 GLY A  82
ALA A 257
LEU A 261
TYR A 260
PHE A  86
 None
 1.28A 1jglH-2fn9A:
undetectable
1jglL-2fn9A:
undetectable		 1jglH-2fn9A:
19.37
1jglL-2fn9A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 114
PHE A 117
ASP A 157
HIS A 153
TYR A 133
 None
 1.23A 1t69A-2fn9A:
undetectable		 1t69A-2fn9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 221
ALA A 205
ILE A 219
GLY A 138
ALA A 177
 None
 0.96A 1utdL-2fn9A:
undetectable
1utdM-2fn9A:
undetectable		 1utdL-2fn9A:
16.13
1utdM-2fn9A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 221
ALA A 205
ILE A 219
GLY A 138
ALA A 177
 None
 0.96A 1utdO-2fn9A:
undetectable
1utdP-2fn9A:
undetectable		 1utdO-2fn9A:
16.13
1utdP-2fn9A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 11 GLY A 221
ALA A 205
ILE A 219
GLY A 138
ALA A 177
 None
 0.97A 1utdP-2fn9A:
undetectable
1utdQ-2fn9A:
undetectable		 1utdP-2fn9A:
16.13
1utdQ-2fn9A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 ASP A  59
TYR A  58
GLU A  33
 None
 0.85A 1vm1A-2fn9A:
undetectable		 1vm1A-2fn9A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 ILE A 194
LEU A 136
GLY A 197
ARG A 174
ALA A 205
 None
 0.89A 2oc8A-2fn9A:
undetectable		 2oc8A-2fn9A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 PHE A 220
LEU A 185
LEU A 136
LEU A 121
TYR A 125
 None
 1.21A 3adsA-2fn9A:
undetectable		 3adsA-2fn9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 11 PRO A 144
ASN A 106
VAL A 273
PHE A  16
ILE A 102
 None
 1.30A 3n23A-2fn9A:
2.2		 3n23A-2fn9A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 ASP A 173
ILE A 139
ASN A 198
ILE A 242
ALA A 170
 None
 1.19A 3ohtA-2fn9A:
undetectable
3ohtB-2fn9A:
undetectable		 3ohtA-2fn9A:
21.11
3ohtB-2fn9A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 PHE A 152
GLY A 221
PHE A 117
ILE A 219
GLY A 197
 None
 1.37A 3ps9A-2fn9A:
undetectable		 3ps9A-2fn9A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 4 VAL A 155
PHE A 152
PHE A 222
VAL A 275
 None
 1.10A 3rv5C-2fn9A:
0.0
3rv5D-2fn9A:
undetectable		 3rv5C-2fn9A:
15.03
3rv5D-2fn9A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 8 ASP A  38
ILE A   8
PHE A  16
VAL A  88
SER A 104
 None
 1.36A 4ac9C-2fn9A:
6.3		 4ac9C-2fn9A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 114
PHE A 117
ASP A 157
HIS A 153
TYR A 133
 None
 1.29A 4qa0A-2fn9A:
undetectable		 4qa0A-2fn9A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 114
PHE A 117
ASP A 157
HIS A 153
TYR A 133
 None
 1.25A 4qa2A-2fn9A:
undetectable		 4qa2A-2fn9A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 114
PHE A 117
ASP A 157
HIS A 153
TYR A 133
 None
 1.27A 4qa2B-2fn9A:
undetectable		 4qa2B-2fn9A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 114
PHE A 117
ASP A 157
HIS A 153
TYR A 133
 None
 1.26A 5eeiA-2fn9A:
2.7		 5eeiA-2fn9A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 114
PHE A 117
ASP A 157
HIS A 153
TYR A 133
 None
 1.26A 5eeiB-2fn9A:
2.8		 5eeiB-2fn9A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 11 SER A  71
ASP A  67
THR A  66
GLU A  46
LEU A  97
 None
 1.30A 5jh7B-2fn9A:
3.9		 5jh7B-2fn9A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 11 SER A  71
ASP A  67
THR A  66
GLU A  46
LEU A  97
 None
 1.26A 5jh7D-2fn9A:
3.9		 5jh7D-2fn9A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 4 VAL A 111
GLY A 109
ASP A 105
ASP A 147
 None
 1.28A 6cjkC-2fn9A:
undetectable		 6cjkC-2fn9A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 PHE A 117
ALA A 113
TYR A 108
THR A 274
VAL A 239
 None
 1.26A 6hu9N-2fn9A:
undetectable		 6hu9N-2fn9A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 11 ASP A 199
ALA A 202
LEU A 136
GLY A 197
ALA A 113
 None
 1.31A 6ieyA-2fn9A:
5.6
6ieyB-2fn9A:
5.2		 6ieyA-2fn9A:
25.29
6ieyB-2fn9A:
25.29