SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fna'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 2fna CONSERVED
HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 ILE A 101
ALA A  97
GLN A  81
ILE A  58
LEU A  80
 None
 1.24A 1dlsA-2fnaA:
undetectable		 1dlsA-2fnaA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 2fna CONSERVED
HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		4 / 5 PHE A 228
TYR A 252
VAL A 233
ASP A 230
 None
 1.38A 1dz6A-2fnaA:
undetectable		 1dz6A-2fnaA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 2fna CONSERVED
HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		4 / 8 PHE A 130
ILE A  58
PHE A 172
LEU A 126
 None
 0.81A 1fslA-2fnaA:
undetectable		 1fslA-2fnaA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2fna CONSERVED
HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		3 / 3 LYS A 303
ILE A 324
THR A 332
 None
 0.73A 1rx3A-2fnaA:
undetectable		 1rx3A-2fnaA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2fna CONSERVED
HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		5 / 8 LEU A 126
LEU A 121
ALA A 159
LEU A 156
PHE A  76
 None
 1.35A 2vcvF-2fnaA:
undetectable		 2vcvF-2fnaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2fna CONSERVED
HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		5 / 8 PHE A 172
LEU A 126
LEU A 121
ALA A 159
LEU A 156
 None
 1.42A 2vcvF-2fnaA:
undetectable		 2vcvF-2fnaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2fna CONSERVED
HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		4 / 7 PHE A 172
LEU A 126
ALA A 159
LEU A 156
 None
 0.87A 2vcvG-2fnaA:
2.4		 2vcvG-2fnaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 2fna CONSERVED
HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		4 / 9 ILE A 140
PHE A 123
ALA A 124
GLU A 128
 None
 0.79A 2vufA-2fnaA:
undetectable		 2vufA-2fnaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 2fna CONSERVED
HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 LEU A  80
PHE A 113
LEU A  98
ILE A 101
SER A 129
 None
 1.48A 2ydoA-2fnaA:
0.0		 2ydoA-2fnaA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 2fna CONSERVED
HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		4 / 6 TYR A 268
ALA A 269
LEU A 272
THR A  40
 None
None
None
ADP  A 500 (-4.5A)
 0.85A 3b6hB-2fnaA:
undetectable		 3b6hB-2fnaA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2fna CONSERVED
HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 ALA A 287
HIS A 334
PHE A 280
LEU A 281
LEU A 292
 None
 1.09A 3nrrB-2fnaA:
undetectable		 3nrrB-2fnaA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 2fna CONSERVED
HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		5 / 12 ILE A  31
ALA A 161
LEU A 160
LEU A 142
LEU A 151
 None
 1.32A 3ozuA-2fnaA:
undetectable		 3ozuA-2fnaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2fna CONSERVED
HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		4 / 7 LEU A 328
LEU A 331
PRO A 346
ILE A 337
 None
 0.87A 3s56B-2fnaA:
undetectable		 3s56B-2fnaA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2fna CONSERVED
HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		3 / 3 LYS A 303
ILE A 324
THR A 332
 None
 0.79A 4gh8A-2fnaA:
undetectable		 4gh8A-2fnaA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2fna CONSERVED
HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		5 / 11 TRP A 244
GLY A 240
PHE A 248
ILE A 251
TYR A 252
 None
 1.32A 4rtrA-2fnaA:
2.4		 4rtrA-2fnaA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 2fna CONSERVED
HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		4 / 6 LEU A 281
LEU A 331
PHE A 280
ILE A 273
 None
 1.25A 4y4dA-2fnaA:
undetectable		 4y4dA-2fnaA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2fna CONSERVED
HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		4 / 7 ILE A  45
PHE A 208
THR A 246
LEU A   2
 None
None
ADP  A 500 (-3.5A)
ADP  A 500 ( 4.9A)
 0.93A 4ze3A-2fnaA:
1.4		 4ze3A-2fnaA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 2fna CONSERVED
HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		4 / 5 LEU A 127
LEU A  98
PHE A 123
LEU A  80
 None
 0.95A 5gtrA-2fnaA:
undetectable		 5gtrA-2fnaA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2fna CONSERVED
HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		5 / 7 ILE A  45
GLY A  41
LEU A 186
PHE A 200
ASP A 143
 None
ADP  A 500 (-3.3A)
None
EDO  A 502 (-4.8A)
MG  A 400 ( 3.9A)
 1.40A 5hieB-2fnaA:
undetectable		 5hieB-2fnaA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2fna CONSERVED
HYPOTHETICAL PROTEIN
(Sulfolobus
solfataricus) 		3 / 3 TYR A 344
ALA A 310
LEU A 311
 None
 0.68A 6ag0C-2fnaA:
undetectable		 6ag0C-2fnaA:
11.52