SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fnc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 TYR A 213
ASP A 217
VAL A 113
ILE A 229
PHE A 159
 MLR  A2913 ( 3.8A)
None
None
None
MLR  A2913 (-4.6A)
 1.07A 1c9hA-2fncA:
undetectable		 1c9hA-2fncA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 149
GLY A 145
GLY A 144
LEU A 207
LEU A 132
 None
 0.83A 1eizA-2fncA:
undetectable		 1eizA-2fncA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 PHE A 323
TYR A 245
TYR A 238
 None
 0.95A 1x70B-2fncA:
undetectable		 1x70B-2fncA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 ILE A 288
ILE A   9
VAL A  34
ILE A 279
PHE A 287
 None
 0.99A 1xozA-2fncA:
undetectable		 1xozA-2fncA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 11 TYR A 213
ASP A 217
VAL A 113
ILE A 229
PHE A 159
 MLR  A2913 ( 3.8A)
None
None
None
MLR  A2913 (-4.6A)
 1.06A 2dg4A-2fncA:
undetectable		 2dg4A-2fncA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 5 ALA A  58
ILE A  61
ASN A 271
ILE A 270
 None
 0.97A 2h4jA-2fncA:
undetectable		 2h4jA-2fncA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 8 ALA A 114
GLY A 264
SER A 326
ALA A 327
 None
 0.90A 2vh3B-2fncA:
undetectable		 2vh3B-2fncA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 5 ILE A  77
PRO A  79
VAL A 310
PHE A  83
 None
 1.16A 2ygnA-2fncA:
undetectable		 2ygnA-2fncA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 ILE A 202
PHE A 150
LEU A 132
SER A 160
TYR A 152
 None
 1.32A 3apwB-2fncA:
undetectable		 3apwB-2fncA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 149
GLY A 145
GLY A 144
LEU A 207
ALA A 136
 None
 0.82A 3douA-2fncA:
undetectable		 3douA-2fncA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 ASN A 230
ASP A 301
GLN A  15
 None
None
MLR  A2913 ( 3.9A)
 0.79A 3eeyC-2fncA:
undetectable		 3eeyC-2fncA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 ASN A 230
ASP A 301
GLN A  15
 None
None
MLR  A2913 ( 3.9A)
 0.79A 3eeyD-2fncA:
undetectable		 3eeyD-2fncA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 ILE A 229
PHE A 157
PHE A 262
GLY A 231
 None
 0.89A 3em0B-2fncA:
undetectable		 3em0B-2fncA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 9 ILE A 288
ILE A 297
LYS A 296
LEU A  22
GLU A  25
 None
 1.17A 3f78A-2fncA:
undetectable		 3f78A-2fncA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 ILE A 139
GLY A 149
VAL A 147
ALA A 136
VAL A 122
 None
 0.94A 3fpjA-2fncA:
undetectable		 3fpjA-2fncA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 SER A 160
LEU A 350
GLY A 190
ALA A 191
LEU A 364
 None
 1.03A 3ln1D-2fncA:
undetectable		 3ln1D-2fncA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 5 ALA A  52
ILE A  77
LEU A  71
ASN A 271
 None
 1.13A 4g19A-2fncA:
undetectable		 4g19A-2fncA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 190
ALA A 191
GLY A 194
PHE A 157
GLY A 166
 None
 0.85A 4o3fA-2fncA:
undetectable		 4o3fA-2fncA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_1
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 LYS A  45
ALA A  64
ASP A  66
ASN A 156
TRP A 233
 None
MLR  A2913 (-3.1A)
MLR  A2913 (-2.8A)
MLR  A2913 (-2.7A)
MLR  A2913 (-4.0A)
 0.83A 4uacA-2fncA:
37.3		 4uacA-2fncA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 ALA A 289
ILE A  80
LEU A  86
PHE A  83
 None
 1.08A 4uymA-2fncA:
undetectable		 4uymA-2fncA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 ALA A 289
ILE A  80
LEU A  86
PHE A  83
 None
 1.04A 4uymB-2fncA:
undetectable		 4uymB-2fncA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 169
GLU A 189
GLY A 190
ILE A 371
GLY A 185
 None
 1.09A 4yvgA-2fncA:
undetectable		 4yvgA-2fncA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 11 ALA A 191
ALA A 187
VAL A 368
LEU A 364
LEU A 350
 None
 1.27A 5eb5A-2fncA:
undetectable		 5eb5A-2fncA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 PRO A 261
ILE A 151
SER A 328
 None
 0.77A 5fsaA-2fncA:
undetectable		 5fsaA-2fncA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 TYR A 213
ASP A 217
VAL A 113
ILE A 229
PHE A 159
 MLR  A2913 ( 3.8A)
None
None
None
MLR  A2913 (-4.6A)
 1.04A 5hkgA-2fncA:
undetectable		 5hkgA-2fncA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 8 ALA A 289
VAL A  36
TYR A 108
GLN A  15
 None
None
None
MLR  A2913 ( 3.9A)
 0.83A 5nu7A-2fncA:
undetectable		 5nu7A-2fncA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 ASN A 188
VAL A 360
ILE A 371
ILE A 353
PHE A 157
 None
 1.46A 6j20A-2fncA:
undetectable		 6j20A-2fncA:
19.87