SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fno'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 2fno AGR_PAT_752P
(Agrobacterium
fabrum) 		5 / 12 ILE A 167
LEU A 157
GLY A  82
VAL A 102
ALA A  99
 None
 1.12A 1axwA-2fnoA:
undetectable		 1axwA-2fnoA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2fno AGR_PAT_752P
(Agrobacterium
fabrum) 		3 / 3 ILE A 194
LEU A 197
VAL A 201
 None
None
SCN  A 238 ( 4.4A)
 0.45A 1mz9B-2fnoA:
undetectable		 1mz9B-2fnoA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 2fno AGR_PAT_752P
(Agrobacterium
fabrum) 		5 / 12 VAL A 234
ILE A 137
PHE A 129
ILE A 227
VAL A 176
 None
 1.18A 1r5lA-2fnoA:
undetectable		 1r5lA-2fnoA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 2fno AGR_PAT_752P
(Agrobacterium
fabrum) 		5 / 12 ILE A 167
LEU A 157
GLY A  82
VAL A 102
ALA A  99
 None
 0.98A 1tlsB-2fnoA:
undetectable		 1tlsB-2fnoA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 2fno AGR_PAT_752P
(Agrobacterium
fabrum) 		5 / 12 ILE A 167
LEU A 157
GLY A  82
VAL A 102
ALA A  99
 None
 1.08A 1tsnA-2fnoA:
undetectable		 1tsnA-2fnoA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 2fno AGR_PAT_752P
(Agrobacterium
fabrum) 		6 / 12 LEU A 172
LEU A 112
LEU A 133
ILE A 137
ILE A 187
ALA A 177
 None
None
None
None
SCN  A 237 ( 3.9A)
SCN  A 237 (-3.4A)
 1.34A 2bxqA-2fnoA:
undetectable		 2bxqA-2fnoA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 2fno AGR_PAT_752P
(Agrobacterium
fabrum) 		5 / 12 LEU A  44
GLY A  58
GLY A  19
ILE A  22
ILE A  41
 None
 0.86A 3k4vA-2fnoA:
undetectable		 3k4vA-2fnoA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2fno AGR_PAT_752P
(Agrobacterium
fabrum) 		3 / 3 VAL A 164
SER A  98
LEU A  88
 None
 0.58A 3n8xA-2fnoA:
undetectable		 3n8xA-2fnoA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 2fno AGR_PAT_752P
(Agrobacterium
fabrum) 		5 / 12 LEU A  44
GLY A  58
GLY A  19
ILE A  22
ILE A  41
 None
 0.86A 3ndtA-2fnoA:
undetectable		 3ndtA-2fnoA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 2fno AGR_PAT_752P
(Agrobacterium
fabrum) 		5 / 12 LEU A  44
GLY A  58
GLY A  19
ILE A  22
ILE A  41
 None
 0.89A 3ndtB-2fnoA:
undetectable		 3ndtB-2fnoA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2fno AGR_PAT_752P
(Agrobacterium
fabrum) 		3 / 3 GLY A  82
ILE A 101
VAL A 102
 None
 0.44A 3nv6A-2fnoA:
0.7		 3nv6A-2fnoA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 2fno AGR_PAT_752P
(Agrobacterium
fabrum) 		6 / 12 LEU A  44
GLY A  58
VAL A  15
GLY A  19
ILE A  22
ILE A  41
 None
 1.00A 3s54A-2fnoA:
undetectable		 3s54A-2fnoA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2fno AGR_PAT_752P
(Agrobacterium
fabrum) 		3 / 3 ILE A 171
MET A  74
ARG A  18
 None
 0.64A 4lnwA-2fnoA:
undetectable		 4lnwA-2fnoA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2fno AGR_PAT_752P
(Agrobacterium
fabrum) 		3 / 3 ILE A 171
MET A  74
ARG A  18
 None
 0.64A 4lnxA-2fnoA:
undetectable		 4lnxA-2fnoA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 2fno AGR_PAT_752P
(Agrobacterium
fabrum) 		5 / 12 LEU A  44
GLY A  58
GLY A  19
ILE A  22
ILE A  41
 None
 0.86A 5e5jB-2fnoA:
undetectable		 5e5jB-2fnoA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 2fno AGR_PAT_752P
(Agrobacterium
fabrum) 		5 / 10 ILE A  87
LEU A  88
ALA A  78
ILE A  79
ILE A  22
 None
 1.04A 5mvmD-2fnoA:
2.4
5mvmE-2fnoA:
2.4		 5mvmD-2fnoA:
15.45
5mvmE-2fnoA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 2fno AGR_PAT_752P
(Agrobacterium
fabrum) 		5 / 12 LEU A  44
GLY A  58
GLY A  19
ILE A  22
ILE A  41
 None
 0.91A 5t8hB-2fnoA:
undetectable		 5t8hB-2fnoA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 2fno AGR_PAT_752P
(Agrobacterium
fabrum) 		4 / 5 ILE A 137
THR A 190
THR A 169
LEU A 149
 None
 1.12A 6f3mD-2fnoA:
undetectable		 6f3mD-2fnoA:
20.00