SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fo5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 2fo5 CYSTEINE PROTEINASE
EP-B 2
(Hordeum
vulgare) 		3 / 3 ALA A 182
VAL A 202
TRP A 184
 None
 0.74A 1bdwA-2fo5A:
undetectable
1bdwB-2fo5A:
undetectable		 1bdwA-2fo5A:
5.64
1bdwB-2fo5A:
5.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 2fo5 CYSTEINE PROTEINASE
EP-B 2
(Hordeum
vulgare) 		6 / 10 GLN A  22
GLY A  26
SER A  27
PHE A  31
SER A  32
GLY A  69
 None
 1.16A 1stfE-2fo5A:
37.1
1stfI-2fo5A:
undetectable		 1stfE-2fo5A:
43.03
1stfI-2fo5A:
15.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 2fo5 CYSTEINE PROTEINASE
EP-B 2
(Hordeum
vulgare) 		7 / 10 GLN A  22
GLY A  26
SER A  27
TRP A  29
PHE A  31
SER A  32
HIS A 167
 None
 0.22A 1stfE-2fo5A:
37.1
1stfI-2fo5A:
undetectable		 1stfE-2fo5A:
43.03
1stfI-2fo5A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 2fo5 CYSTEINE PROTEINASE
EP-B 2
(Hordeum
vulgare) 		4 / 5 VAL A 138
TYR A 221
VAL A 121
ASP A 128
 None
 1.22A 2x45C-2fo5A:
undetectable		 2x45C-2fo5A:
20.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 2fo5 CYSTEINE PROTEINASE
EP-B 2
(Hordeum
vulgare) 		4 / 7 GLN A  22
GLY A  26
HIS A 167
TRP A 190
 None
 0.43A 3ai8A-2fo5A:
28.3		 3ai8A-2fo5A:
30.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 2fo5 CYSTEINE PROTEINASE
EP-B 2
(Hordeum
vulgare) 		4 / 8 ALA A  42
SER A  47
ARG A  44
TYR A 226
 None
 1.10A 4ijiF-2fo5A:
undetectable		 4ijiF-2fo5A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 2fo5 CYSTEINE PROTEINASE
EP-B 2
(Hordeum
vulgare) 		5 / 9 LEU A 129
GLY A 173
VAL A 138
SER A 139
VAL A 140
 None
 1.19A 4qd3A-2fo5A:
undetectable		 4qd3A-2fo5A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2fo5 CYSTEINE PROTEINASE
EP-B 2
(Hordeum
vulgare) 		4 / 6 SER A  52
GLY A  69
ASP A  65
GLY A  26
 None
 0.88A 5cdnC-2fo5A:
undetectable
5cdnD-2fo5A:
undetectable		 5cdnC-2fo5A:
20.08
5cdnD-2fo5A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2fo5 CYSTEINE PROTEINASE
EP-B 2
(Hordeum
vulgare) 		4 / 6 SER A  52
GLY A  69
ASP A  65
GLY A  26
 None
 0.89A 5cdnT-2fo5A:
undetectable
5cdnU-2fo5A:
undetectable		 5cdnT-2fo5A:
20.08
5cdnU-2fo5A:
20.95