SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2foi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 JPA  A 500 (-3.7A)
JPA  A 500 (-4.4A)
JPA  A 500 (-4.1A)
NAD  A 450 (-4.9A)
 0.97A 1kifA-2foiA:
2.8		 1kifA-2foiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 JPA  A 500 (-3.7A)
JPA  A 500 (-4.4A)
JPA  A 500 (-4.1A)
NAD  A 450 (-4.9A)
 0.97A 1kifB-2foiA:
2.8		 1kifB-2foiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 JPA  A 500 (-3.7A)
JPA  A 500 (-4.4A)
JPA  A 500 (-4.1A)
NAD  A 450 (-4.9A)
 0.97A 1kifC-2foiA:
2.8		 1kifC-2foiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 JPA  A 500 (-3.7A)
JPA  A 500 (-4.4A)
JPA  A 500 (-4.1A)
NAD  A 450 (-4.9A)
 0.97A 1kifD-2foiA:
2.8		 1kifD-2foiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 JPA  A 500 (-3.7A)
JPA  A 500 (-4.4A)
JPA  A 500 (-4.1A)
NAD  A 450 (-4.9A)
 0.97A 1kifE-2foiA:
2.8		 1kifE-2foiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 JPA  A 500 (-3.7A)
JPA  A 500 (-4.4A)
JPA  A 500 (-4.1A)
NAD  A 450 (-4.9A)
 0.97A 1kifF-2foiA:
2.8		 1kifF-2foiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 JPA  A 500 (-3.7A)
JPA  A 500 (-4.4A)
JPA  A 500 (-4.1A)
NAD  A 450 (-4.9A)
 0.97A 1kifG-2foiA:
2.8		 1kifG-2foiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 JPA  A 500 (-3.7A)
JPA  A 500 (-4.4A)
JPA  A 500 (-4.1A)
NAD  A 450 (-4.9A)
 0.97A 1kifH-2foiA:
2.8		 1kifH-2foiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 JPA  A 500 (-3.7A)
JPA  A 500 (-4.4A)
JPA  A 500 (-4.1A)
NAD  A 450 (-4.9A)
 1.00A 1ve9A-2foiA:
2.7		 1ve9A-2foiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 JPA  A 500 (-3.7A)
JPA  A 500 (-4.4A)
JPA  A 500 (-4.1A)
NAD  A 450 (-4.9A)
 1.01A 2du8G-2foiA:
2.8		 2du8G-2foiA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 JPA  A 500 (-3.7A)
JPA  A 500 (-4.4A)
JPA  A 500 (-4.1A)
NAD  A 450 (-4.9A)
 1.03A 2du8J-2foiA:
2.7		 2du8J-2foiA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		5 / 12 ALA A 116
GLY A 106
GLY A 110
TRP A 113
ILE A 137
 None
NAD  A 450 (-3.6A)
NAD  A 450 (-3.2A)
None
None
 1.08A 2plwA-2foiA:
3.8		 2plwA-2foiA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 8 ALA A 312
TYR A 111
ILE A 310
HIS A 214
 NAD  A 450 (-3.8A)
NAD  A 450 (-4.7A)
None
None
 0.97A 2zm8A-2foiA:
undetectable		 2zm8A-2foiA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 8 ALA A 312
TYR A 111
ILE A 310
HIS A 214
 NAD  A 450 (-3.8A)
NAD  A 450 (-4.7A)
None
None
 0.97A 2zmaA-2foiA:
undetectable		 2zmaA-2foiA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		3 / 3 ARG A 318
ASP A 168
ASN A 218
 None
NAD  A 450 (-3.8A)
NAD  A 450 (-4.1A)
 0.73A 2zzmA-2foiA:
5.1		 2zzmA-2foiA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 8 THR A 229
LEU A 226
SER A 282
ASN A 218
 None
None
None
NAD  A 450 (-4.1A)
 1.07A 3kp2A-2foiA:
undetectable
3kp2B-2foiA:
undetectable		 3kp2A-2foiA:
19.70
3kp2B-2foiA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 7 ASN A 218
ALA A 219
ALA A 322
ARG A 318
 NAD  A 450 (-4.1A)
JPA  A 500 (-4.0A)
None
None
 1.07A 3twpA-2foiA:
undetectable		 3twpA-2foiA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 7 ASN A 218
ALA A 219
ALA A 322
ARG A 318
 NAD  A 450 (-4.1A)
JPA  A 500 (-4.0A)
None
None
 1.03A 3twpB-2foiA:
undetectable		 3twpB-2foiA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 7 ASN A 218
ALA A 219
ALA A 322
ARG A 318
 NAD  A 450 (-4.1A)
JPA  A 500 (-4.0A)
None
None
 1.03A 3twpC-2foiA:
undetectable		 3twpC-2foiA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		5 / 9 ILE A 115
GLY A 112
ILE A 105
ILE A  99
VAL A 124
 None
 1.14A 4nptA-2foiA:
undetectable		 4nptA-2foiA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		3 / 3 TRP A 113
ILE A 153
SER A 120
 None
 0.92A 5gqbA-2foiA:
undetectable		 5gqbA-2foiA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 6 ILE A 105
ILE A 209
LEU A 212
HIS A 214
 None
 0.95A 5vkqB-2foiA:
undetectable
5vkqC-2foiA:
undetectable		 5vkqB-2foiA:
10.96
5vkqC-2foiA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 6 ILE A 130
ILE A 209
LEU A 212
HIS A 214
 None
 1.03A 5vkqB-2foiA:
undetectable
5vkqC-2foiA:
undetectable		 5vkqB-2foiA:
10.96
5vkqC-2foiA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 6 ILE A 105
ILE A 209
LEU A 212
HIS A 214
 None
 0.93A 5vkqC-2foiA:
undetectable
5vkqD-2foiA:
undetectable		 5vkqC-2foiA:
10.96
5vkqD-2foiA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 6 ILE A 130
ILE A 209
LEU A 212
HIS A 214
 None
 1.01A 5vkqC-2foiA:
undetectable
5vkqD-2foiA:
undetectable		 5vkqC-2foiA:
10.96
5vkqD-2foiA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_F_BEZF201_0
(NS3 PROTEASE)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 5 HIS A 214
ALA A 169
SER A 244
TYR A 243
 None
NAD  A 450 (-3.5A)
None
None
 1.29A 5yodF-2foiA:
undetectable		 5yodF-2foiA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		5 / 9 ALA A 284
ALA A 219
GLY A 280
GLY A 233
SER A 239
 None
JPA  A 500 (-4.0A)
None
None
None
 1.16A 6bklE-2foiA:
undetectable
6bklF-2foiA:
undetectable
6bklG-2foiA:
undetectable
6bklH-2foiA:
undetectable		 6bklE-2foiA:
6.93
6bklF-2foiA:
6.93
6bklG-2foiA:
6.93
6bklH-2foiA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2foi ENOYL-ACYL CARRIER
REDUCTASE
(Plasmodium
falciparum) 		4 / 6 ASP A 176
TYR A 251
GLU A 196
ASP A 197
 None
 1.35A 6mn5C-2foiA:
undetectable		 6mn5C-2foiA:
15.33