SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fom'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 2fom POLYPROTEIN
(Dengue
virus) 		4 / 4 ILE B  25
MET B  49
VAL B 146
GLY B  37
 None
None
CL  B 201 (-4.1A)
None
 1.17A 1e06B-2fomB:
undetectable		 1e06B-2fomB:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 2fom POLYPROTEIN
(Dengue
virus) 		5 / 9 ILE B  36
PHE B  46
VAL B  52
ALA B  56
LEU B  58
 None
None
None
GOL  B 203 ( 4.0A)
None
 1.10A 2m9qA-2fomB:
11.4		 2m9qA-2fomB:
98.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 2fom POLYPROTEIN
POLYPROTEIN
(Dengue
virus;
Dengue
virus) 		6 / 9 LEU A  51
PHE B  46
THR B  48
VAL B  52
ALA B  56
LEU B  58
 None
None
None
None
GOL  B 203 ( 4.0A)
None
 0.90A 2m9qA-2fomA:
undetectable		 2m9qA-2fomA:
90.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 2fom POLYPROTEIN
(Dengue
virus) 		4 / 6 PHE B  46
TYR B  79
THR B  53
VAL B  52
 None
 1.28A 3lb3A-2fomB:
undetectable		 3lb3A-2fomB:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2fom POLYPROTEIN
(Dengue
virus) 		5 / 12 HIS B  51
VAL B  72
ASP B  75
GLY B 133
SER B 135
 None
 0.74A 3sueC-2fomB:
10.7		 3sueC-2fomB:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1103_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2fom POLYPROTEIN
(Dengue
virus) 		4 / 5 ARG B  64
MET B  59
HIS B  60
LEU A  53
 None
 1.30A 4g5jA-2fomB:
0.0		 4g5jA-2fomB:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2fom POLYPROTEIN
(Dengue
virus) 		3 / 3 VAL B  40
ALA B  38
PHE B  46
 None
 0.89A 4olbA-2fomB:
undetectable		 4olbA-2fomB:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2fom POLYPROTEIN
(Dengue
virus) 		3 / 3 VAL B  40
ALA B  38
PHE B  46
 None
 0.83A 4w5nA-2fomB:
undetectable		 4w5nA-2fomB:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2fom POLYPROTEIN
(Dengue
virus) 		3 / 3 VAL B  40
ALA B  38
PHE B  46
 None
 0.90A 5js1A-2fomB:
undetectable		 5js1A-2fomB:
12.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 2fom POLYPROTEIN
(Dengue
virus) 		4 / 5 HIS B  51
SER B 135
TYR B 150
GLY B 151
 None
 0.55A 5yodH-2fomB:
22.9		 5yodH-2fomB:
54.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2fom POLYPROTEIN
(Dengue
virus) 		5 / 10 ILE B 165
VAL B  40
ALA B  22
LEU B 149
LEU B  85
 None
None
None
None
CL  B 201 ( 4.5A)
 0.87A 6f6nA-2fomB:
undetectable
6f6nB-2fomB:
undetectable		 6f6nA-2fomB:
22.01
6f6nB-2fomB:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_B_PQNB2002_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2fom POLYPROTEIN
(Dengue
virus) 		5 / 9 SER B 131
ILE B  25
ALA B  38
LEU B 100
ALA B  99
 None
 1.14A 6hqbB-2fomB:
undetectable		 6hqbB-2fomB:
18.39