SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fon'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 11 THR A 384
VAL A 347
LEU A 484
ALA A 486
VAL A 483
None
1.16A 1rv7A-2fonA:
undetectable
1rv7B-2fonA:
undetectable
1rv7A-2fonA:
8.78
1rv7B-2fonA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
4 / 7 ASP A 224
TYR A 234
MET A 237
ASP A 238
None
FAD  A1000 ( 4.2A)
None
None
1.26A 1t03A-2fonA:
undetectable
1t03A-2fonA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
3 / 3 SER A 491
VAL A 434
LEU A 438
None
0.68A 1yajG-2fonA:
undetectable
1yajG-2fonA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
4 / 5 PHE A 344
THR A 388
LEU A 337
ALA A 341
None
1.14A 2e1qD-2fonA:
1.1
2e1qD-2fonA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 12 SER A 166
THR A 151
VAL A 206
ALA A 186
VAL A 222
None
1.15A 2nniA-2fonA:
1.5
2nniA-2fonA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 12 PHE A  16
ALA A  14
ARG A  11
VAL A 300
LEU A 555
None
1.20A 2rctA-2fonA:
undetectable
2rctA-2fonA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
4 / 7 GLY A  27
ALA A  26
TRP A  25
ALA A 606
None
0.80A 3ur0B-2fonA:
undetectable
3ur0B-2fonA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
4 / 8 SER A 236
ASN A 235
ARG A  58
GLY A 177
None
None
None
FAD  A1000 (-4.4A)
1.03A 4af0A-2fonA:
undetectable
4af0A-2fonA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
4 / 7 LEU A 519
ALA A 523
LEU A 432
SER A 382
None
1.15A 4iklA-2fonA:
undetectable
4iklB-2fonA:
undetectable
4iklA-2fonA:
10.93
4iklB-2fonA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 12 TYR A 559
CYH A 556
GLU A 537
LEU A 529
LEU A 561
None
1.14A 4k36B-2fonA:
undetectable
4k36B-2fonA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 6 ARG A 597
ALA A 308
ASP A 326
LEU A   7
SER A 602
None
1.09A 4ot2A-2fonA:
undetectable
4ot2A-2fonA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 11 HIS A  30
SER A  28
THR A  35
ARG A 345
ALA A  26
None
1.45A 4qvlH-2fonA:
undetectable
4qvlN-2fonA:
undetectable
4qvlH-2fonA:
16.42
4qvlN-2fonA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 10 HIS A  30
SER A  28
THR A  35
ARG A 345
ALA A  26
None
1.46A 4qvvH-2fonA:
0.0
4qvvN-2fonA:
0.0
4qvvH-2fonA:
16.42
4qvvN-2fonA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 11 HIS A  30
SER A  28
THR A  35
ARG A 345
ALA A  26
None
1.46A 4qw1V-2fonA:
undetectable
4qw1b-2fonA:
undetectable
4qw1V-2fonA:
16.42
4qw1b-2fonA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 11 HIS A  30
SER A  28
THR A  35
ARG A 345
ALA A  26
None
1.47A 4qw1H-2fonA:
undetectable
4qw1N-2fonA:
undetectable
4qw1H-2fonA:
16.42
4qw1N-2fonA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 11 HIS A  30
SER A  28
THR A  35
ARG A 345
ALA A  26
None
1.43A 4qwuV-2fonA:
undetectable
4qwub-2fonA:
undetectable
4qwuV-2fonA:
16.42
4qwub-2fonA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 11 HIS A  30
SER A  28
THR A  35
ARG A 345
ALA A  26
None
1.42A 4qwuH-2fonA:
undetectable
4qwuN-2fonA:
undetectable
4qwuH-2fonA:
16.42
4qwuN-2fonA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 9 ALA A 435
ALA A 522
SER A 495
ALA A 525
SER A 491
None
1.27A 4twdA-2fonA:
2.8
4twdB-2fonA:
3.0
4twdC-2fonA:
2.8
4twdD-2fonA:
2.9
4twdE-2fonA:
3.0
4twdA-2fonA:
18.93
4twdB-2fonA:
18.93
4twdC-2fonA:
18.93
4twdD-2fonA:
18.93
4twdE-2fonA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 9 ALA A 522
SER A 495
ALA A 525
SER A 491
ALA A 435
None
1.20A 4twdA-2fonA:
2.8
4twdB-2fonA:
3.0
4twdC-2fonA:
2.8
4twdD-2fonA:
2.9
4twdE-2fonA:
3.0
4twdA-2fonA:
18.93
4twdB-2fonA:
18.93
4twdC-2fonA:
18.93
4twdD-2fonA:
18.93
4twdE-2fonA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
4 / 5 ASP A   9
VAL A   4
ASP A 622
GLY A 623
None
1.23A 4xp6A-2fonA:
undetectable
4xp6A-2fonA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
4 / 7 THR A 377
LEU A 380
LEU A 351
THR A 454
None
0.93A 4z90A-2fonA:
2.7
4z90B-2fonA:
2.9
4z90C-2fonA:
3.2
4z90D-2fonA:
3.2
4z90E-2fonA:
2.7
4z90A-2fonA:
19.30
4z90B-2fonA:
19.30
4z90C-2fonA:
19.30
4z90D-2fonA:
19.30
4z90E-2fonA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 10 ARG A 597
ALA A 308
ASP A 326
LEU A   7
SER A 602
None
1.15A 4zbrA-2fonA:
undetectable
4zbrA-2fonA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 11 HIS A  30
SER A  28
THR A  35
ARG A 345
ALA A  26
None
1.48A 5bxnV-2fonA:
undetectable
5bxnb-2fonA:
undetectable
5bxnV-2fonA:
16.13
5bxnb-2fonA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 11 HIS A  30
SER A  28
THR A  35
ARG A 345
ALA A  26
None
1.48A 5bxnH-2fonA:
undetectable
5bxnN-2fonA:
undetectable
5bxnH-2fonA:
16.13
5bxnN-2fonA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_A_RAUA400_1
(IMINE REDUCTASE)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 11 VAL A 548
LEU A 555
TYR A 535
PHE A 346
GLY A 557
None
1.44A 5g6sA-2fonA:
0.7
5g6sG-2fonA:
1.0
5g6sA-2fonA:
18.91
5g6sG-2fonA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_B_RAUB400_1
(IMINE REDUCTASE)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 11 VAL A 548
LEU A 555
TYR A 535
PHE A 346
GLY A 557
None
1.44A 5g6sB-2fonA:
1.1
5g6sC-2fonA:
1.0
5g6sB-2fonA:
18.91
5g6sC-2fonA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 12 GLY A 557
VAL A 548
LEU A 555
TYR A 535
PHE A 346
None
1.45A 5g6sB-2fonA:
1.0
5g6sC-2fonA:
undetectable
5g6sB-2fonA:
18.91
5g6sC-2fonA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_D_RAUD400_1
(IMINE REDUCTASE)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 10 VAL A 548
LEU A 555
TYR A 535
PHE A 346
GLY A 557
None
1.44A 5g6sD-2fonA:
0.7
5g6sF-2fonA:
0.7
5g6sD-2fonA:
18.91
5g6sF-2fonA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_E_RAUE400_1
(IMINE REDUCTASE)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 11 VAL A 548
LEU A 555
TYR A 535
PHE A 346
GLY A 557
None
1.44A 5g6sE-2fonA:
0.8
5g6sH-2fonA:
1.1
5g6sE-2fonA:
18.91
5g6sH-2fonA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_F_RAUF400_1
(IMINE REDUCTASE)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 10 GLY A 557
VAL A 548
LEU A 555
TYR A 535
PHE A 346
None
1.41A 5g6sD-2fonA:
0.7
5g6sF-2fonA:
0.9
5g6sD-2fonA:
18.91
5g6sF-2fonA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_G_RAUG400_1
(IMINE REDUCTASE)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 10 GLY A 557
VAL A 548
LEU A 555
TYR A 535
PHE A 346
None
1.44A 5g6sA-2fonA:
0.7
5g6sG-2fonA:
1.0
5g6sA-2fonA:
18.91
5g6sG-2fonA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
3 / 3 GLY A 425
GLN A 433
LYS A 381
None
0.98A 5imsB-2fonA:
undetectable
5imsB-2fonA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 12 ALA A 290
PHE A  16
ALA A  14
THR A 304
LEU A 338
None
1.04A 5tl8A-2fonA:
undetectable
5tl8A-2fonA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)
2fon PEROXISOMAL ACYL-COA
OXIDASE 1A

(Solanum
lycopersicum)
5 / 12 ALA A 290
PHE A  16
ALA A  14
THR A 304
LEU A 338
None
1.04A 6aycA-2fonA:
undetectable
6aycA-2fonA:
7.94