SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fp7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 2fp7 GENOME POLYPROTEIN
(West
Nile
virus) 		5 / 12 GLY B 153
GLY B 151
LEU B 149
GLY B 136
TYR B 130
 None
 1.25A 1y4lA-2fp7B:
undetectable		 1y4lA-2fp7B:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 2fp7 GENOME POLYPROTEIN
(West
Nile
virus) 		4 / 6 LEU B  49
GLY B 151
SER B 163
ILE B 139
 None
 0.72A 1yajF-2fp7B:
undetectable		 1yajF-2fp7B:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 2fp7 GENOME POLYPROTEIN
(West
Nile
virus) 		4 / 8 VAL B  99
GLY B 133
THR B 134
ALA B  38
 None
 0.74A 3aruA-2fp7B:
undetectable		 3aruA-2fp7B:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 2fp7 GENOME POLYPROTEIN
(West
Nile
virus) 		4 / 5 ALA B  38
LEU B  49
GLY B 151
THR B 111
 None
 0.96A 3dl9A-2fp7B:
undetectable		 3dl9A-2fp7B:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2fp7 GENOME POLYPROTEIN
(West
Nile
virus) 		5 / 12 HIS B  51
VAL B  72
ASP B  75
GLY B 133
SER B 135
 None
 0.96A 3sueC-2fp7B:
12.1		 3sueC-2fp7B:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2fp7 GENOME POLYPROTEIN
(West
Nile
virus) 		5 / 12 HIS B  51
VAL B  72
ASP B  75
GLY B 133
SER B 135
 None
 0.85A 3sufD-2fp7B:
12.4		 3sufD-2fp7B:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2fp7 GENOME POLYPROTEIN
GENOME POLYPROTEIN
(West
Nile
virus;
West
Nile
virus) 		6 / 12 VAL A  75
GLY B 153
GLY B 151
ILE B 162
ILE B 155
LEU A  87
 None
 1.35A 4iv0A-2fp7A:
undetectable		 4iv0A-2fp7A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 2fp7 GENOME POLYPROTEIN
(West
Nile
virus) 		5 / 11 ASP B 129
VAL B  99
TYR B 150
SER B 135
GLY B 133
 None
 1.20A 4mmaA-2fp7B:
undetectable		 4mmaA-2fp7B:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2fp7 GENOME POLYPROTEIN
GENOME POLYPROTEIN
(West
Nile
virus;
West
Nile
virus) 		6 / 12 VAL A  75
GLY B 153
GLY B 151
ILE B 162
ILE B 155
LEU A  87
 None
 1.37A 4mwzB-2fp7A:
undetectable		 4mwzB-2fp7A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2fp7 GENOME POLYPROTEIN
(West
Nile
virus) 		3 / 3 VAL B  40
ALA B  38
PHE B  46
 None
 0.85A 4olbA-2fp7B:
undetectable		 4olbA-2fp7B:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 2fp7 GENOME POLYPROTEIN
(West
Nile
virus) 		3 / 3 LEU B 149
MET B  97
TYR B  23
 None
 0.95A 4p6xG-2fp7B:
undetectable		 4p6xG-2fp7B:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2fp7 GENOME POLYPROTEIN
GENOME POLYPROTEIN
(West
Nile
virus;
West
Nile
virus) 		5 / 12 ILE A  60
GLY B 144
ASN B 143
VAL B 140
ILE B  98
 None
 1.13A 4rvgA-2fp7A:
undetectable		 4rvgA-2fp7A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2fp7 GENOME POLYPROTEIN
(West
Nile
virus) 		3 / 3 VAL B  40
ALA B  38
PHE B  46
 None
 0.81A 4w5nA-2fp7B:
undetectable		 4w5nA-2fp7B:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2fp7 GENOME POLYPROTEIN
(West
Nile
virus) 		3 / 3 VAL B  40
ALA B  38
PHE B  46
 None
 0.87A 5js1A-2fp7B:
undetectable		 5js1A-2fp7B:
12.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 2fp7 GENOME POLYPROTEIN
(West
Nile
virus) 		4 / 5 HIS B  51
SER B 135
GLY B 151
TYR B 161
 None
 0.54A 5yodB-2fp7B:
27.9		 5yodB-2fp7B:
62.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 2fp7 GENOME POLYPROTEIN
(West
Nile
virus) 		4 / 5 HIS B  51
SER B 135
GLY B 151
TYR B 161
 None
 0.37A 5yodD-2fp7B:
28.0		 5yodD-2fp7B:
62.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YOD_F_BEZF201_0
(NS3 PROTEASE)		 2fp7 GENOME POLYPROTEIN
(West
Nile
virus) 		4 / 5 HIS B  51
SER B 135
TYR B 150
TYR B 161
 None
 0.59A 5yodF-2fp7B:
27.6		 5yodF-2fp7B:
62.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 2fp7 GENOME POLYPROTEIN
(West
Nile
virus) 		5 / 5 HIS B  51
SER B 135
TYR B 150
GLY B 151
TYR B 161
 None
 0.48A 5yodH-2fp7B:
27.6		 5yodH-2fp7B:
62.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 2fp7 GENOME POLYPROTEIN
(West
Nile
virus) 		5 / 12 VAL B  22
VAL B  40
MET B  97
THR B 132
GLY B 133
 None
 1.09A 6brdC-2fp7B:
undetectable		 6brdC-2fp7B:
19.25