SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fpo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 2fpo METHYLASE YHHF
(Escherichia
coli) 		6 / 12 ASN A 109
ASP A 127
PHE A  60
GLY A  62
SER A  63
MET A  83
 CL  A 401 (-4.7A)
None
None
None
None
None
 0.90A 1g60A-2fpoA:
3.0		 1g60A-2fpoA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 2fpo METHYLASE YHHF
(Escherichia
coli) 		5 / 12 PHE A 125
LEU A  57
PHE A  60
LEU A 142
LEU A  43
 None
 1.02A 1og5A-2fpoA:
undetectable		 1og5A-2fpoA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 2fpo METHYLASE YHHF
(Escherichia
coli) 		4 / 7 ASP A  58
ALA A  61
VAL A 105
ILE A  12
 None
 0.78A 1t7iB-2fpoA:
undetectable		 1t7iB-2fpoA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 2fpo METHYLASE YHHF
(Escherichia
coli) 		4 / 7 ASP A  58
ALA A  61
VAL A 105
ILE A  12
 None
 0.76A 1t7jB-2fpoA:
undetectable		 1t7jB-2fpoA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 2fpo METHYLASE YHHF
(Escherichia
coli) 		5 / 12 GLY A  62
LEU A  66
ASP A  84
ASP A 127
PRO A 129
 None
 1.11A 2f8lA-2fpoA:
14.4		 2f8lA-2fpoA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2fpo METHYLASE YHHF
(Escherichia
coli) 		4 / 7 LEU A 114
PRO A 129
ARG A 131
GLU A  82
 None
 1.05A 2jn3A-2fpoA:
undetectable		 2jn3A-2fpoA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2fpo METHYLASE YHHF
(Escherichia
coli) 		5 / 12 ASP A  58
GLY A  62
LEU A  66
ASP A  84
LEU A 134
 None
None
None
None
CL  A 401 (-4.5A)
 0.69A 2nxeA-2fpoA:
15.6		 2nxeA-2fpoA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2fpo METHYLASE YHHF
(Escherichia
coli) 		5 / 12 ASP A  58
GLY A  62
LEU A  66
ASP A  84
LEU A 134
 None
None
None
None
CL  A 401 (-4.5A)
 0.65A 2nxeB-2fpoA:
15.9		 2nxeB-2fpoA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2fpo METHYLASE YHHF
(Escherichia
coli) 		5 / 12 ALA A 110
PRO A 129
PHE A  60
GLY A  62
GLU A  82
 CL  A 401 (-3.8A)
None
None
None
None
 0.72A 2zifA-2fpoA:
2.8		 2zifA-2fpoA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 2fpo METHYLASE YHHF
(Escherichia
coli) 		5 / 12 PHE A  60
GLY A  64
LEU A  66
PRO A 129
LEU A 134
 None
None
None
None
CL  A 401 (-4.5A)
 0.99A 3av6A-2fpoA:
8.2		 3av6A-2fpoA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2fpo METHYLASE YHHF
(Escherichia
coli) 		5 / 12 GLY A  62
SER A  63
LEU A  66
ASP A  84
LEU A 134
 None
None
None
None
CL  A 401 (-4.5A)
 0.58A 3cjtG-2fpoA:
15.9		 3cjtG-2fpoA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2fpo METHYLASE YHHF
(Escherichia
coli) 		5 / 12 GLY A  62
SER A  63
LEU A  66
ASP A  84
LEU A 134
 None
None
None
None
CL  A 401 (-4.5A)
 0.58A 3cjtO-2fpoA:
15.9		 3cjtO-2fpoA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 2fpo METHYLASE YHHF
(Escherichia
coli) 		5 / 12 PHE A  60
GLY A  67
ASP A  84
PRO A 129
LEU A 134
 None
None
None
None
CL  A 401 (-4.5A)
 1.00A 3eeoA-2fpoA:
9.9		 3eeoA-2fpoA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 2fpo METHYLASE YHHF
(Escherichia
coli) 		5 / 12 GLY A  62
GLU A  82
ASP A  84
ALA A 110
PRO A 129
 None
None
None
CL  A 401 (-3.8A)
None
 0.82A 3fuuA-2fpoA:
13.5		 3fuuA-2fpoA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 2fpo METHYLASE YHHF
(Escherichia
coli) 		4 / 8 GLU A 176
LEU A 173
TYR A 187
LEU A 164
 None
 0.95A 3i45A-2fpoA:
2.1		 3i45A-2fpoA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2fpo METHYLASE YHHF
(Escherichia
coli) 		5 / 12 GLY A  64
ASP A  84
ASP A 127
PRO A 129
LEU A 134
 None
None
None
None
CL  A 401 (-4.5A)
 0.93A 3m6vA-2fpoA:
13.0		 3m6vA-2fpoA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2fpo METHYLASE YHHF
(Escherichia
coli) 		5 / 12 GLY A  64
ASP A  84
ASP A 127
PRO A 129
LEU A 134
 None
None
None
None
CL  A 401 (-4.5A)
 0.96A 3m6vB-2fpoA:
12.7		 3m6vB-2fpoA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 2fpo METHYLASE YHHF
(Escherichia
coli) 		5 / 10 ASP A  58
ALA A  61
VAL A 105
ILE A  12
LEU A  80
 None
 0.83A 3ogqA-2fpoA:
undetectable		 3ogqA-2fpoA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2fpo METHYLASE YHHF
(Escherichia
coli) 		5 / 12 GLY A  62
SER A  63
ASP A  84
PRO A 129
LEU A 134
 None
None
None
None
CL  A 401 (-4.5A)
 1.18A 3v8vA-2fpoA:
17.3		 3v8vA-2fpoA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 2fpo METHYLASE YHHF
(Escherichia
coli) 		5 / 11 ILE A  12
LEU A  95
ASP A  58
LEU A  66
ALA A  70
 None
 1.18A 4fogD-2fpoA:
undetectable		 4fogD-2fpoA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 2fpo METHYLASE YHHF
(Escherichia
coli) 		3 / 3 LEU A  71
VAL A  52
ASP A  53
 None
 0.49A 4y8wC-2fpoA:
undetectable		 4y8wC-2fpoA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2fpo METHYLASE YHHF
(Escherichia
coli) 		4 / 7 GLY A  62
SER A  63
GLU A  82
ASP A 127
 None
 0.76A 5ergB-2fpoA:
15.6		 5ergB-2fpoA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2fpo METHYLASE YHHF
(Escherichia
coli) 		6 / 12 ALA A 110
ASP A 127
PRO A 129
PHE A  60
GLY A  62
GLU A  82
 CL  A 401 (-3.8A)
None
None
None
None
None
 0.88A 5hfjA-2fpoA:
3.2		 5hfjA-2fpoA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2fpo METHYLASE YHHF
(Escherichia
coli) 		5 / 12 ALA A 110
ASP A 127
PRO A 129
PHE A  60
GLY A  62
 CL  A 401 (-3.8A)
None
None
None
None
 0.91A 5hfjB-2fpoA:
4.0		 5hfjB-2fpoA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2fpo METHYLASE YHHF
(Escherichia
coli) 		6 / 12 ALA A 110
ASP A 127
PHE A  60
GLY A  62
SER A  63
GLU A  82
 CL  A 401 (-3.8A)
None
None
None
None
None
 0.83A 5hfjD-2fpoA:
4.3		 5hfjD-2fpoA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2fpo METHYLASE YHHF
(Escherichia
coli) 		6 / 12 ALA A 110
ASP A 127
PRO A 129
PHE A  60
GLY A  62
GLU A  82
 CL  A 401 (-3.8A)
None
None
None
None
None
 0.84A 5hfjD-2fpoA:
4.3		 5hfjD-2fpoA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2fpo METHYLASE YHHF
(Escherichia
coli) 		6 / 12 ALA A 110
ASP A 127
PHE A  60
GLY A  62
SER A  63
GLU A  82
 CL  A 401 (-3.8A)
None
None
None
None
None
 0.78A 5hfjE-2fpoA:
3.8		 5hfjE-2fpoA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2fpo METHYLASE YHHF
(Escherichia
coli) 		6 / 12 ALA A 110
ASP A 127
PRO A 129
PHE A  60
GLY A  62
GLU A  82
 CL  A 401 (-3.8A)
None
None
None
None
None
 0.87A 5hfjF-2fpoA:
3.0		 5hfjF-2fpoA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2fpo METHYLASE YHHF
(Escherichia
coli) 		5 / 12 ALA A 110
ASP A 127
PRO A 129
PHE A  60
GLY A  62
 CL  A 401 (-3.8A)
None
None
None
None
 1.05A 5hfjG-2fpoA:
3.5		 5hfjG-2fpoA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2fpo METHYLASE YHHF
(Escherichia
coli) 		5 / 12 ALA A 110
ASP A 127
PRO A 129
PHE A  60
GLY A  62
 CL  A 401 (-3.8A)
None
None
None
None
 0.92A 5hfjH-2fpoA:
4.4		 5hfjH-2fpoA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 2fpo METHYLASE YHHF
(Escherichia
coli) 		3 / 3 TYR A 155
ASP A  58
ASP A 127
 None
 0.84A 5x6yA-2fpoA:
7.4		 5x6yA-2fpoA:
14.95