SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fpr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2fpr HISTIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
HISB
(Escherichia
coli) 		3 / 3 CYH A  94
CYH A 102
HIS A  96
 ZN  A 502 (-2.3A)
ZN  A 502 (-2.3A)
ZN  A 502 (-3.2A)
 0.75A 3dtuB-2fprA:
undetectable		 3dtuB-2fprA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 2fpr HISTIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
HISB
(Escherichia
coli) 		3 / 3 CYH A  94
CYH A 102
HIS A  96
 ZN  A 502 (-2.3A)
ZN  A 502 (-2.3A)
ZN  A 502 (-3.2A)
 0.73A 3dtuD-2fprA:
undetectable		 3dtuD-2fprA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2fpr HISTIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
HISB
(Escherichia
coli) 		4 / 7 PHE A  81
PHE A  88
LYS A  50
GLY A  48
 None
 1.09A 3em0B-2fprA:
undetectable		 3em0B-2fprA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 2fpr HISTIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
HISB
(Escherichia
coli) 		4 / 6 ILE A  16
HIS A  74
LEU A  31
ASP A  12
 None
 1.18A 3oi8A-2fprA:
undetectable		 3oi8A-2fprA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 2fpr HISTIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
HISB
(Escherichia
coli) 		4 / 8 VAL A  91
TYR A 115
ILE A  93
ILE A  54
 None
 1.02A 4afgD-2fprA:
undetectable
4afgE-2fprA:
undetectable		 4afgD-2fprA:
20.34
4afgE-2fprA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2fpr HISTIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
HISB
(Escherichia
coli) 		4 / 7 ILE A  93
VAL A  37
ILE A   9
ASN A  75
 None
 0.84A 5hieC-2fprA:
undetectable		 5hieC-2fprA:
23.10