SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fq1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 2fq1 ISOCHORISMATASE
(Escherichia
coli) 		5 / 12 ALA A 177
LEU A 178
ILE A  72
LEU A 206
LEU A 190
 None
 1.14A 1errB-2fq1A:
undetectable		 1errB-2fq1A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2fq1 ISOCHORISMATASE
(Escherichia
coli) 		5 / 8 GLY A 242
ILE A 239
PRO A 232
ILE A 273
ILE A 222
 MG  A 997 (-4.4A)
None
None
None
None
 1.42A 1hshD-2fq1A:
undetectable		 1hshD-2fq1A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2fq1 ISOCHORISMATASE
(Escherichia
coli) 		5 / 9 LEU A 238
LEU A 223
LEU A 218
ARG A 219
ILE A 273
 None
 1.02A 2f7aA-2fq1A:
undetectable		 2f7aA-2fq1A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 2fq1 ISOCHORISMATASE
(Escherichia
coli) 		3 / 3 ARG A 247
GLU A 231
SER A 245
 MG  A 997 ( 4.4A)
None
None
 0.86A 2xkkA-2fq1A:
3.1
2xkkC-2fq1A:
2.8		 2xkkA-2fq1A:
17.69
2xkkC-2fq1A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 2fq1 ISOCHORISMATASE
(Escherichia
coli) 		5 / 12 ASN A  20
VAL A 174
ALA A 175
ALA A 161
MET A 202
 None
 1.23A 3dl9B-2fq1A:
undetectable		 3dl9B-2fq1A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_B_NIOB311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 2fq1 ISOCHORISMATASE
(Escherichia
coli) 		5 / 11 ASP A  37
PHE A  42
TRP A  95
LYS A 123
TYR A 126
 None
 0.89A 3r2jB-2fq1A:
19.6		 3r2jB-2fq1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 2fq1 ISOCHORISMATASE
(Escherichia
coli) 		5 / 12 ASP A  37
PHE A  42
TRP A  95
LYS A 123
TYR A 126
 None
 0.95A 3r2jC-2fq1A:
19.8		 3r2jC-2fq1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_D_NIOD311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 2fq1 ISOCHORISMATASE
(Escherichia
coli) 		5 / 11 ASP A  37
PHE A  42
TRP A  95
LYS A 123
TYR A 126
 None
 0.88A 3r2jD-2fq1A:
19.6		 3r2jD-2fq1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2fq1 ISOCHORISMATASE
(Escherichia
coli) 		4 / 7 VAL A 108
ILE A  35
ILE A  60
ALA A  61
 None
 0.89A 4lv9A-2fq1A:
undetectable		 4lv9A-2fq1A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2fq1 ISOCHORISMATASE
(Escherichia
coli) 		4 / 6 VAL A 120
ALA A  78
GLN A  39
VAL A 108
 None
 1.01A 5i8fA-2fq1A:
undetectable		 5i8fA-2fq1A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2fq1 ISOCHORISMATASE
(Escherichia
coli) 		5 / 10 LEU A 112
ALA A 153
SER A 189
PRO A  12
LEU A  11
 None
 1.31A 5mm4B-2fq1A:
3.7		 5mm4B-2fq1A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2fq1 ISOCHORISMATASE
(Escherichia
coli) 		5 / 10 ILE A  35
ILE A  17
ALA A 175
LEU A 178
ALA A 153
 None
 1.48A 5zjiB-2fq1A:
undetectable		 5zjiB-2fq1A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2fq1 ISOCHORISMATASE
(Escherichia
coli) 		5 / 12 SER A 102
THR A 100
PHE A  45
PHE A  42
LEU A   6
 None
 1.33A 6a93A-2fq1A:
undetectable		 6a93A-2fq1A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2fq1 ISOCHORISMATASE
(Escherichia
coli) 		5 / 12 SER A 102
THR A 100
PHE A  45
PHE A  42
LEU A   6
 None
 1.29A 6a93B-2fq1A:
undetectable		 6a93B-2fq1A:
22.57