SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fq4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)
2fq4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Bacillus
cereus)
4 / 6 LEU A  18
SER A  21
TYR A  22
LEU A  25
None
0.61A 3f33A-2fq4A:
undetectable
3f33A-2fq4A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)
2fq4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Bacillus
cereus)
5 / 12 LEU A 166
ARG A 165
ALA A  92
ASP A 175
ASP A 174
None
1.22A 3gwuA-2fq4A:
undetectable
3gwuA-2fq4A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)
2fq4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Bacillus
cereus)
4 / 7 ASN A 104
ILE A 102
PHE A  64
MET A  61
None
1.11A 3tvxB-2fq4A:
undetectable
3tvxB-2fq4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
2fq4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Bacillus
cereus)
4 / 7 TYR A 177
VAL A 178
LEU A 181
ASN A 104
None
1.12A 4e1gB-2fq4A:
undetectable
4e1gB-2fq4A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)
2fq4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Bacillus
cereus)
5 / 8 TYR A 124
ILE A 103
ASP A 113
LEU A 116
GLY A 110
None
1.38A 4iqqD-2fq4A:
undetectable
4iqqD-2fq4A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
2fq4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Bacillus
cereus)
4 / 7 MET A  61
ARG A 128
PHE A 125
GLU A 119
None
1.39A 4jseA-2fq4A:
1.2
4jseB-2fq4A:
undetectable
4jseA-2fq4A:
19.85
4jseB-2fq4A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
2fq4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Bacillus
cereus)
4 / 5 LEU A 157
PHE A 186
ILE A 158
ILE A  84
None
0.99A 5dzk4-2fq4A:
undetectable
5dzkg-2fq4A:
undetectable
5dzkm-2fq4A:
undetectable
5dzkn-2fq4A:
undetectable
5dzk4-2fq4A:
8.00
5dzkg-2fq4A:
25.82
5dzkm-2fq4A:
25.56
5dzkn-2fq4A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)
2fq4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Bacillus
cereus)
3 / 3 TRP A  53
ILE A  38
SER A  21
None
0.96A 5gqbA-2fq4A:
undetectable
5gqbA-2fq4A:
16.73