SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fqh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YKI_A_NFZA1219_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2fqh	HYPOTHETICAL PROTEIN TA0938 (Thermoplasma acidophilum)	4 / 8	PHE A 50 ASN A 52 GLU A 37 GLY A 36	None	0.86A	1ykiA-2fqhA: undetectable 1ykiB-2fqhA: undetectable	1ykiA-2fqhA: 19.16 1ykiB-2fqhA: 19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YKI_B_NFZB2219_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2fqh	HYPOTHETICAL PROTEIN TA0938 (Thermoplasma acidophilum)	4 / 8	PHE A 50 ASN A 52 GLU A 37 GLY A 36	None	0.87A	1ykiA-2fqhA: undetectable 1ykiB-2fqhA: undetectable	1ykiA-2fqhA: 19.16 1ykiB-2fqhA: 19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YKI_C_NFZC3219_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2fqh	HYPOTHETICAL PROTEIN TA0938 (Thermoplasma acidophilum)	4 / 8	PHE A 50 ASN A 52 GLU A 37 GLY A 36	None	0.88A	1ykiC-2fqhA: undetectable 1ykiD-2fqhA: undetectable	1ykiC-2fqhA: 19.16 1ykiD-2fqhA: 19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YKI_D_NFZD4219_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2fqh	HYPOTHETICAL PROTEIN TA0938 (Thermoplasma acidophilum)	4 / 8	PHE A 50 ASN A 52 GLU A 37 GLY A 36	None	0.88A	1ykiC-2fqhA: undetectable 1ykiD-2fqhA: undetectable	1ykiC-2fqhA: 19.16 1ykiD-2fqhA: 19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PTH_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	2fqh	HYPOTHETICAL PROTEIN TA0938 (Thermoplasma acidophilum)	3 / 3	ASP A 38 LEU A 39 PHE A 40	None	0.58A	4pthA-2fqhA: undetectable	4pthA-2fqhA: 19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5O4Y_D_CCSD14_0 (PHE-MAA-ASN-PRO-HIS- LEU-SER-TRP-SER-TRP- 9KK-9KK-ARG-CCS-GLY- NH2 PROGRAMMED CELL DEATH 1 LIGAND 1)	2fqh	HYPOTHETICAL PROTEIN TA0938 (Thermoplasma acidophilum)	5 / 12	SER A 15 GLY A 14 GLY A 86 VAL A 8 ARG A 63	None	1.30A	5o4yD-2fqhA: undetectable 5o4yE-2fqhA: undetectable	5o4yD-2fqhA: 9.23 5o4yE-2fqhA: 22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DWJ_B_GLYB710_0 (DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1)	2fqh	HYPOTHETICAL PROTEIN TA0938 (Thermoplasma acidophilum)	4 / 5	ARG A 89 GLY A 10 ASN A 9 ASP A 88	None	1.23A	6dwjB-2fqhA: undetectable 6dwjD-2fqhA: undetectable	6dwjB-2fqhA: 10.56 6dwjD-2fqhA: 10.56

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1YKI_A_NFZA1219_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2fqh","HYPOTHETICAL PROTEIN TA0938","Thermoplasma acidophilum",4,"PHE A  50;ASN A  52;GLU A  37;GLY A  36","None","0.86A","1ykiA-2fqhA:undetectable;1ykiB-2fqhA:undetectable","1ykiA-2fqhA:19.16;1ykiB-2fqhA:19.16"],["1YKI_B_NFZB2219_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2fqh","HYPOTHETICAL PROTEIN TA0938","Thermoplasma acidophilum",4,"PHE A  50;ASN A  52;GLU A  37;GLY A  36","None","0.87A","1ykiA-2fqhA:undetectable;1ykiB-2fqhA:undetectable","1ykiA-2fqhA:19.16;1ykiB-2fqhA:19.16"],["1YKI_C_NFZC3219_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2fqh","HYPOTHETICAL PROTEIN TA0938","Thermoplasma acidophilum",4,"PHE A  50;ASN A  52;GLU A  37;GLY A  36","None","0.88A","1ykiC-2fqhA:undetectable;1ykiD-2fqhA:undetectable","1ykiC-2fqhA:19.16;1ykiD-2fqhA:19.16"],["1YKI_D_NFZD4219_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2fqh","HYPOTHETICAL PROTEIN TA0938","Thermoplasma acidophilum",4,"PHE A  50;ASN A  52;GLU A  37;GLY A  36","None","0.88A","1ykiC-2fqhA:undetectable;1ykiD-2fqhA:undetectable","1ykiC-2fqhA:19.16;1ykiD-2fqhA:19.16"],["4PTH_A_FOLA201_1","DIHYDROFOLATE REDUCTASE","2fqh","HYPOTHETICAL PROTEIN TA0938","Thermoplasma acidophilum",3,"ASP A  38;LEU A  39;PHE A  40","None","0.58A","4pthA-2fqhA:undetectable","4pthA-2fqhA:19.87"],["5O4Y_D_CCSD14_0","PHE-MAA-ASN-PRO-HIS-LEU-SER-TRP-SER-TRP-9KK-9KK-ARG-CCS-GLY-NH2;PROGRAMMED CELL DEATH 1 LIGAND 1","2fqh","HYPOTHETICAL PROTEIN TA0938","Thermoplasma acidophilum",5,"SER A  15;GLY A  14;GLY A  86;VAL A   8;ARG A  63","None","1.30A","5o4yD-2fqhA:undetectable;5o4yE-2fqhA:undetectable","5o4yD-2fqhA:9.23;5o4yE-2fqhA:22.03"],["6DWJ_B_GLYB710_0","DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1","2fqh","HYPOTHETICAL PROTEIN TA0938","Thermoplasma acidophilum",4,"ARG A  89;GLY A  10;ASN A   9;ASP A  88","None","1.23A","6dwjB-2fqhA:undetectable;6dwjD-2fqhA:undetectable","6dwjB-2fqhA:10.56;6dwjD-2fqhA:10.56"]]