SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fr1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		4 / 6 LEU A1820
VAL A1761
ILE A1769
ARG A1902
 None
 1.10A 1opjB-2fr1A:
undetectable		 1opjB-2fr1A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		5 / 12 ILE A1681
ALA A1843
VAL A1837
PHE A1750
ALA A1872
 None
 0.92A 1sg9C-2fr1A:
5.8		 1sg9C-2fr1A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		4 / 8 TYR A1898
PHE A1894
PHE A1856
ALA A1802
 None
 1.05A 1x8vA-2fr1A:
undetectable		 1x8vA-2fr1A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		5 / 12 GLY A1672
ARG A1698
ASP A1726
ALA A1753
ALA A1775
 NDP  A 301 ( 4.0A)
NDP  A 301 (-3.9A)
NDP  A 301 (-3.4A)
NDP  A 301 ( 3.7A)
NDP  A 301 (-3.3A)
 0.84A 2br4C-2fr1A:
6.0		 2br4C-2fr1A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		5 / 12 GLY A1672
ARG A1698
ASP A1726
ALA A1753
ALA A1775
 NDP  A 301 ( 4.0A)
NDP  A 301 (-3.9A)
NDP  A 301 (-3.4A)
NDP  A 301 ( 3.7A)
NDP  A 301 (-3.3A)
 0.81A 2br4F-2fr1A:
6.0		 2br4F-2fr1A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		5 / 10 ALA A1542
LEU A1549
ALA A1591
LEU A1778
VAL A1777
 None
 1.06A 2bxeA-2fr1A:
undetectable		 2bxeA-2fr1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		6 / 10 ALA A1542
LEU A1549
LEU A1544
ALA A1591
LEU A1778
VAL A1777
 None
 1.40A 2bxgB-2fr1A:
undetectable		 2bxgB-2fr1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		3 / 3 ALA A1591
GLY A1766
SER A1773
 None
 0.39A 2ivuA-2fr1A:
undetectable		 2ivuA-2fr1A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		5 / 12 SER A1630
GLY A1632
GLY A1631
ALA A1626
GLY A1463
 None
 0.92A 2pkkA-2fr1A:
4.7		 2pkkA-2fr1A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		5 / 12 SER A1630
GLY A1632
GLY A1631
ALA A1626
GLY A1463
 None
 0.90A 2pkmA-2fr1A:
4.7		 2pkmA-2fr1A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		4 / 7 ARG A1890
ARG A1893
PHE A1894
PHE A1805
 None
 1.14A 2qb4A-2fr1A:
undetectable		 2qb4A-2fr1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		4 / 7 ILE A1887
ARG A1890
ARG A1893
PHE A1894
 None
 1.07A 2qb4A-2fr1A:
undetectable		 2qb4A-2fr1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		4 / 6 ARG A1890
ARG A1893
PHE A1894
PHE A1805
 None
 1.24A 2qeiA-2fr1A:
undetectable		 2qeiA-2fr1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		4 / 8 VAL A1668
GLY A1689
GLY A1717
ALA A1718
 None
 0.75A 3aruA-2fr1A:
3.4		 3aruA-2fr1A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		3 / 3 MET A1864
VAL A1450
GLU A1867
 None
 0.75A 3c6gA-2fr1A:
undetectable		 3c6gA-2fr1A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		5 / 12 ASP A1757
SER A1773
THR A1552
PRO A1815
GLY A1811
 None
 1.30A 3j6pB-2fr1A:
5.5		 3j6pB-2fr1A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		5 / 11 LEU A1877
ALA A1690
LEU A1746
PHE A1750
THR A1835
 None
 1.48A 3jwqB-2fr1A:
undetectable
3jwqC-2fr1A:
undetectable		 3jwqB-2fr1A:
21.59
3jwqC-2fr1A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		4 / 6 GLU A1541
ARG A1509
ALA A1542
ALA A1545
 None
 1.19A 3ns1C-2fr1A:
undetectable		 3ns1C-2fr1A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		3 / 3 GLY A1759
ILE A1599
VAL A1598
 None
 0.52A 3nv6A-2fr1A:
undetectable		 3nv6A-2fr1A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		3 / 3 PRO A1461
THR A1462
LEU A1638
 None
 0.67A 3ttrA-2fr1A:
1.0		 3ttrA-2fr1A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		5 / 11 ALA A1814
LEU A1810
SER A1799
VAL A1889
ILE A1885
 None
 1.43A 4claA-2fr1A:
undetectable		 4claA-2fr1A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		5 / 12 LEU A1685
TRP A1839
ALA A1753
GLY A1678
GLY A1672
 None
None
NDP  A 301 ( 3.7A)
None
NDP  A 301 ( 4.0A)
 1.02A 4rn6B-2fr1A:
undetectable		 4rn6B-2fr1A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		3 / 3 THR A1755
HIS A1784
LEU A1797
 None
 0.83A 5axdC-2fr1A:
5.7		 5axdC-2fr1A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		5 / 12 ILE A1769
ILE A1599
GLY A1596
GLY A1594
VAL A1761
 None
 1.01A 5twjA-2fr1A:
undetectable		 5twjA-2fr1A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		5 / 10 ILE A1769
ILE A1599
GLY A1596
GLY A1594
VAL A1761
 None
 0.98A 5twjB-2fr1A:
undetectable		 5twjB-2fr1A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		5 / 12 ARG A1774
VAL A1595
LEU A1592
GLY A1766
ILE A1769
 None
 1.18A 5vooA-2fr1A:
3.0		 5vooA-2fr1A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		5 / 12 ARG A1774
VAL A1595
LEU A1592
GLY A1766
ILE A1769
 None
 1.16A 5vooB-2fr1A:
3.4		 5vooB-2fr1A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		5 / 12 ARG A1774
VAL A1595
LEU A1592
GLY A1766
ILE A1769
 None
 1.18A 5vooC-2fr1A:
3.0		 5vooC-2fr1A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		4 / 6 PHE A1856
ARG A1857
ARG A1858
ALA A1807
 None
 0.98A 6b89B-2fr1A:
2.3		 6b89B-2fr1A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		4 / 7 PHE A1856
ARG A1857
ARG A1858
ALA A1807
 None
 1.24A 6b89A-2fr1A:
2.0		 6b89A-2fr1A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		5 / 9 ALA A1818
ALA A1802
SER A1803
GLY A1594
GLY A1811
 None
 1.05A 6bklE-2fr1A:
undetectable
6bklF-2fr1A:
undetectable
6bklG-2fr1A:
undetectable
6bklH-2fr1A:
undetectable		 6bklE-2fr1A:
4.81
6bklF-2fr1A:
4.81
6bklG-2fr1A:
4.81
6bklH-2fr1A:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		5 / 12 LEU A1549
LEU A1553
GLY A1594
GLY A1596
GLY A1609
 None
 1.10A 6ce2B-2fr1A:
undetectable		 6ce2B-2fr1A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		5 / 11 ALA A1818
LEU A1764
ASP A1757
ALA A1591
LEU A1592
 None
 1.33A 6dk1B-2fr1A:
undetectable		 6dk1B-2fr1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI
(Saccharopolyspor
a
erythraea) 		5 / 10 VAL A1796
ALA A1794
LEU A1685
THR A1793
LEU A1873
 None
 0.91A 6f5uA-2fr1A:
undetectable
6f5uB-2fr1A:
undetectable		 6f5uA-2fr1A:
10.50
6f5uB-2fr1A:
10.46