SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fr2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_C_KLNC1498_1 (CYTOCHROME P450 3A4)	2fr2	HYPOTHETICAL PROTEIN RV2717C (Mycobacterium tuberculosis)	5 / 12	LEU A 49 LEU A 71 PHE A 41 ALA A 11 GLU A 107	None	1.25A	2v0mC-2fr2A: undetectable	2v0mC-2fr2A: 17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OHT_A_1N1A1000_2 (P38A)	2fr2	HYPOTHETICAL PROTEIN RV2717C (Mycobacterium tuberculosis)	3 / 3	GLU A 67 LEU A 83 LEU A 118	None	0.52A	3ohtA-2fr2A: undetectable	3ohtA-2fr2A: 21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OHT_B_1N1B1000_2 (P38A)	2fr2	HYPOTHETICAL PROTEIN RV2717C (Mycobacterium tuberculosis)	3 / 3	GLU A 67 LEU A 83 LEU A 118	None	0.53A	3ohtB-2fr2A: undetectable	3ohtB-2fr2A: 21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_F_377F401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	2fr2	HYPOTHETICAL PROTEIN RV2717C (Mycobacterium tuberculosis)	4 / 7	GLU A 37 GLU A 67 LEU A 108 TYR A 141	None	1.08A	4twdF-2fr2A: undetectable 4twdJ-2fr2A: undetectable	4twdF-2fr2A: 19.56 4twdJ-2fr2A: 19.56

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2V0M_C_KLNC1498_1","CYTOCHROME P450 3A4","2fr2","HYPOTHETICAL PROTEIN RV2717C","Mycobacterium tuberculosis",5,"LEU A  49;LEU A  71;PHE A  41;ALA A  11;GLU A 107","None","1.25A","2v0mC-2fr2A:undetectable","2v0mC-2fr2A:17.53"],["3OHT_A_1N1A1000_2","P38A","2fr2","HYPOTHETICAL PROTEIN RV2717C","Mycobacterium tuberculosis",3,"GLU A  67;LEU A  83;LEU A 118","None","0.52A","3ohtA-2fr2A:undetectable","3ohtA-2fr2A:21.68"],["3OHT_B_1N1B1000_2","P38A","2fr2","HYPOTHETICAL PROTEIN RV2717C","Mycobacterium tuberculosis",3,"GLU A  67;LEU A  83;LEU A 118","None","0.53A","3ohtB-2fr2A:undetectable","3ohtB-2fr2A:21.68"],["4TWD_F_377F401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","2fr2","HYPOTHETICAL PROTEIN RV2717C","Mycobacterium tuberculosis",4,"GLU A  37;GLU A  67;LEU A 108;TYR A 141","None","1.08A","4twdF-2fr2A:undetectable;4twdJ-2fr2A:undetectable","4twdF-2fr2A:19.56;4twdJ-2fr2A:19.56"]]