SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fre'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fre NAD(P)H-FLAVIN
OXIDOREDUCTASE
(Agrobacterium
fabrum) 		4 / 8 LEU A  73
GLN A  79
PHE A  90
LEU A 147
 None
 0.82A 2eilP-2freA:
undetectable
2eilW-2freA:
undetectable		 2eilP-2freA:
19.72
2eilW-2freA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2fre NAD(P)H-FLAVIN
OXIDOREDUCTASE
(Agrobacterium
fabrum) 		4 / 7 THR A 163
TYR A 130
ASP A  27
SER A  86
 None
 1.15A 2xytI-2freA:
undetectable		 2xytI-2freA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 2fre NAD(P)H-FLAVIN
OXIDOREDUCTASE
(Agrobacterium
fabrum) 		4 / 8 ALA A 125
ILE A 161
ALA A  43
ALA A  42
 None
 0.66A 3r9tA-2freA:
undetectable		 3r9tA-2freA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2fre NAD(P)H-FLAVIN
OXIDOREDUCTASE
(Agrobacterium
fabrum) 		4 / 5 GLY A 136
GLY A 137
MET A  75
ASN A  78
 FMN  A1151 (-3.9A)
FMN  A1151 (-3.7A)
None
FMN  A1151 (-3.0A)
 1.00A 4fglC-2freA:
undetectable		 4fglC-2freA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2fre NAD(P)H-FLAVIN
OXIDOREDUCTASE
(Agrobacterium
fabrum) 		3 / 3 SER A  86
ALA A 160
VAL A 159
 None
 0.44A 4o2bA-2freA:
undetectable		 4o2bA-2freA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2fre NAD(P)H-FLAVIN
OXIDOREDUCTASE
(Agrobacterium
fabrum) 		3 / 3 SER A  86
ALA A 160
VAL A 159
 None
 0.49A 4o2bC-2freA:
undetectable		 4o2bC-2freA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2fre NAD(P)H-FLAVIN
OXIDOREDUCTASE
(Agrobacterium
fabrum) 		3 / 3 SER A  86
ALA A 160
VAL A 159
 None
 0.54A 4x1iA-2freA:
undetectable		 4x1iA-2freA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2fre NAD(P)H-FLAVIN
OXIDOREDUCTASE
(Agrobacterium
fabrum) 		4 / 7 LEU A  73
GLN A  79
PHE A  90
LEU A 147
 None
 0.93A 5b1aC-2freA:
undetectable
5b1aJ-2freA:
undetectable		 5b1aC-2freA:
19.72
5b1aJ-2freA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2fre NAD(P)H-FLAVIN
OXIDOREDUCTASE
(Agrobacterium
fabrum) 		4 / 7 LEU A  73
GLN A  79
PHE A  90
LEU A 147
 None
 0.93A 5b1aP-2freA:
undetectable
5b1aW-2freA:
undetectable		 5b1aP-2freA:
19.72
5b1aW-2freA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2fre NAD(P)H-FLAVIN
OXIDOREDUCTASE
(Agrobacterium
fabrum) 		4 / 7 LEU A  73
GLN A  79
PHE A  90
LEU A 147
 None
 0.88A 5b3sC-2freA:
undetectable
5b3sJ-2freA:
undetectable		 5b3sC-2freA:
19.72
5b3sJ-2freA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2fre NAD(P)H-FLAVIN
OXIDOREDUCTASE
(Agrobacterium
fabrum) 		3 / 3 SER A  86
ALA A 160
VAL A 159
 None
 0.53A 5eypA-2freA:
undetectable		 5eypA-2freA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2fre NAD(P)H-FLAVIN
OXIDOREDUCTASE
(Agrobacterium
fabrum) 		4 / 7 LEU A  73
GLN A  79
PHE A  90
LEU A 147
 None
 0.90A 5iy5C-2freA:
undetectable
5iy5J-2freA:
undetectable		 5iy5C-2freA:
21.59
5iy5J-2freA:
14.14