SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2frv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_2
(DIHYDROFOLATE
REDUCTASE)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		4 / 4 TRP L  36
LEU L  21
ARG L 522
THR L 509
 None
 1.29A 1ao8A-2frvL:
undetectable		 1ao8A-2frvL:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		4 / 8 GLY L 508
ILE L 507
VAL L 524
ILE L 520
 None
 0.69A 1d4yB-2frvL:
undetectable		 1d4yB-2frvL:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		4 / 6 TRP L  36
GLY L 508
ASN L  34
PRO L 510
 None
 1.34A 1dedA-2frvL:
undetectable		 1dedA-2frvL:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		3 / 3 GLU L 365
TRP L 304
LYS L  31
 None
 1.22A 1qu2A-2frvL:
2.4		 1qu2A-2frvL:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		4 / 6 TYR L 325
ALA L 331
ARG L 353
PRO L 492
 None
 1.38A 2ql8A-2frvL:
undetectable
2ql8B-2frvL:
undetectable		 2ql8A-2frvL:
13.80
2ql8B-2frvL:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		4 / 7 PHE L 480
LEU L 466
ALA L  79
ALA L  57
 None
FCO  L 537 (-3.4A)
None
None
 1.02A 2vcvG-2frvL:
undetectable		 2vcvG-2frvL:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		4 / 7 LEU L  45
ALA L 532
GLY L 534
PHE L 480
 None
 0.90A 2wq5A-2frvL:
undetectable		 2wq5A-2frvL:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		5 / 10 THR L 509
ILE L  32
GLY L 508
GLY L 275
THR L 523
 None
 1.01A 2y7wB-2frvL:
undetectable		 2y7wB-2frvL:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		4 / 6 ASP L 119
VAL L  11
ILE L  14
TYR L 174
 None
 1.17A 2yfbB-2frvL:
4.3		 2yfbB-2frvL:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		5 / 8 LEU L 261
ALA L 412
GLY L 266
LEU L 397
GLY L 398
 None
 1.45A 2yfxA-2frvL:
undetectable		 2yfxA-2frvL:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		4 / 6 GLN L 417
GLY L 370
HIS L 108
HIS L 111
 None
 1.43A 3ai8B-2frvL:
undetectable		 3ai8B-2frvL:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		3 / 3 TYR L 268
ASP L 189
HIS L 179
 None
 0.79A 3e23A-2frvL:
undetectable		 3e23A-2frvL:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		4 / 6 LEU L 234
ASN L 435
SER L 233
PHE L 213
 None
 1.42A 3i9jB-2frvL:
undetectable		 3i9jB-2frvL:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		4 / 8 ILE L  14
SER L  37
SER L  39
PRO L 529
 None
 0.66A 3lslA-2frvL:
undetectable
3lslD-2frvL:
undetectable		 3lslA-2frvL:
20.98
3lslD-2frvL:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		4 / 8 PRO L 529
ILE L  14
SER L  37
SER L  39
 None
 0.78A 3lslA-2frvL:
undetectable
3lslD-2frvL:
undetectable		 3lslA-2frvL:
20.98
3lslD-2frvL:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		3 / 3 PHE L 252
LYS L 144
SER L 142
 None
 1.33A 3tyeB-2frvL:
undetectable		 3tyeB-2frvL:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		4 / 7 THR L 407
TRP L 271
TRP L 120
HIS L 116
 None
 1.44A 4a3uA-2frvL:
undetectable		 4a3uA-2frvL:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		4 / 7 THR L 407
TRP L 271
TRP L 120
HIS L 116
 None
 1.45A 4a3uB-2frvL:
undetectable		 4a3uB-2frvL:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		4 / 6 GLU L  24
ILE L  23
GLU L  18
VAL L 535
 None
 1.07A 4ejwB-2frvL:
undetectable		 4ejwB-2frvL:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		4 / 5 SER L  37
GLY L 491
THR L  40
VAL L 535
 None
 1.02A 4eohA-2frvL:
undetectable		 4eohA-2frvL:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		4 / 5 GLU L 290
ARG L  78
PRO L 287
SER L 295
 None
 1.12A 4k17B-2frvL:
undetectable		 4k17B-2frvL:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		5 / 12 GLN L 417
ASP L 107
HIS L 108
SER L 374
ARG L 296
 None
 1.37A 4kmuC-2frvL:
0.0		 4kmuC-2frvL:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		3 / 3 LEU L 318
PHE L 314
ILE L 319
 None
 0.73A 5dzk1-2frvL:
undetectable
5dzkF-2frvL:
undetectable
5dzkM-2frvL:
undetectable		 5dzk1-2frvL:
0.76
5dzkF-2frvL:
17.20
5dzkM-2frvL:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		4 / 7 LEU L 490
TYR L 527
THR L 411
LEU L  21
 None
 0.97A 5jq7B-2frvL:
0.0		 5jq7B-2frvL:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		3 / 3 ALA L  73
GLN L 221
THR L 223
 None
 0.68A 5n0oA-2frvL:
undetectable		 5n0oA-2frvL:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		6 / 12 LEU L  94
ALA L  92
ILE L 212
GLU L 433
ALA L 209
PHE L 222
 None
 1.40A 5n5dB-2frvL:
undetectable		 5n5dB-2frvL:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		4 / 6 HIS L 116
LEU L 408
THR L 407
TRP L 271
 None
 1.19A 5ogjA-2frvL:
undetectable		 5ogjA-2frvL:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		4 / 6 HIS L 116
LEU L 408
THR L 407
TRP L 271
 None
 1.17A 5ogjB-2frvL:
undetectable		 5ogjB-2frvL:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		4 / 6 HIS L 116
LEU L 408
THR L 407
TRP L 271
 None
 1.18A 5ohhB-2frvL:
undetectable		 5ohhB-2frvL:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		3 / 3 GLU L 368
ARG L 410
TYR L 527
 None
 0.64A 5trqB-2frvL:
undetectable		 5trqB-2frvL:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CCV_C_RFPC1205_1
(-)		 2frv PERIPLASMIC
HYDROGENASE
(Desulfovibrio
gigas) 		5 / 12 GLN L 417
ASP L 107
HIS L 108
SER L 374
ARG L 296
 None
 1.34A 6ccvC-2frvL:
undetectable		 6ccvC-2frvL:
18.36