SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2frx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
5 / 12 VAL A 108
LEU A 111
ALA A 190
ALA A 147
ILE A 145
None
0.93A 1fk6A-2frxA:
undetectable
1fk6A-2frxA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
3 / 3 PHE A 180
LEU A 146
LEU A 374
None
0.66A 1mx1E-2frxA:
undetectable
1mx1E-2frxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
4 / 7 TRP A 351
ILE A 340
LEU A 405
TRP A 397
None
1.13A 1q0yH-2frxA:
undetectable
1q0yL-2frxA:
undetectable
1q0yH-2frxA:
18.58
1q0yL-2frxA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
4 / 6 LEU A  64
TRP A  62
LEU A  86
PHE A  97
None
1.39A 1ru9H-2frxA:
undetectable
1ru9L-2frxA:
undetectable
1ru9H-2frxA:
18.85
1ru9L-2frxA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
4 / 6 LEU A  64
TRP A  62
LEU A  86
PHE A  97
None
1.46A 1rukH-2frxA:
undetectable
1rukL-2frxA:
undetectable
1rukH-2frxA:
18.85
1rukL-2frxA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
5 / 12 ALA A 127
GLY A 129
GLY A 177
ARG A 178
PRO A 196
None
0.90A 1sqfA-2frxA:
32.3
1sqfA-2frxA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
5 / 9 LEU A 357
LEU A 355
ALA A 344
LEU A 405
ALA A 401
None
1.07A 2vcvH-2frxA:
2.2
2vcvH-2frxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
5 / 9 LEU A 357
LEU A 355
ALA A 344
LEU A 405
ALA A 401
None
1.07A 2vcvI-2frxA:
undetectable
2vcvI-2frxA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
5 / 12 ILE A 167
LEU A  46
ILE A 145
VAL A 108
PHE A 112
None
1.10A 2ygpA-2frxA:
undetectable
2ygpA-2frxA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
5 / 12 LEU A 452
GLY A 451
VAL A 430
LEU A 460
LEU A 442
None
1.28A 3cjtK-2frxA:
13.9
3cjtK-2frxA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
4 / 7 GLY A 129
ASP A 123
ILE A 145
GLN A 134
None
0.92A 3fi0P-2frxA:
undetectable
3fi0P-2frxA:
21.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3M6V_A_SAMA465_0
(RRNA METHYLASE)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
6 / 12 ALA A 125
PRO A 128
GLY A 129
ARG A 154
ASP A 194
PRO A 196
None
1.05A 3m6vA-2frxA:
38.2
3m6vA-2frxA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3M6V_A_SAMA465_0
(RRNA METHYLASE)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
6 / 12 ALA A 125
PRO A 128
GLY A 129
ASP A 194
PRO A 196
LEU A 228
None
0.84A 3m6vA-2frxA:
38.2
3m6vA-2frxA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3M6V_A_SAMA465_0
(RRNA METHYLASE)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
6 / 12 PRO A 128
GLY A 129
LYS A 131
ARG A 154
ASP A 194
PRO A 196
None
1.27A 3m6vA-2frxA:
38.2
3m6vA-2frxA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3M6V_B_SAMB465_0
(RRNA METHYLASE)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
6 / 12 ALA A 125
PRO A 128
GLY A 129
ARG A 154
ASP A 194
PRO A 196
None
1.07A 3m6vB-2frxA:
38.2
3m6vB-2frxA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3M6V_B_SAMB465_0
(RRNA METHYLASE)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
6 / 12 ALA A 125
PRO A 128
GLY A 129
ASP A 194
PRO A 196
LEU A 228
None
0.85A 3m6vB-2frxA:
38.2
3m6vB-2frxA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3M6V_B_SAMB465_0
(RRNA METHYLASE)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
6 / 12 PRO A 128
GLY A 129
LYS A 131
ARG A 154
ASP A 194
PRO A 196
None
1.25A 3m6vB-2frxA:
38.2
3m6vB-2frxA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3M6W_A_SAMA465_0
(RRNA METHYLASE)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
5 / 12 ALA A 125
PRO A 128
GLY A 129
ARG A 154
PRO A 196
None
0.98A 3m6wA-2frxA:
38.1
3m6wA-2frxA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3M6W_A_SAMA465_0
(RRNA METHYLASE)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
5 / 12 ALA A 125
PRO A 128
GLY A 129
PRO A 196
LEU A 228
None
0.70A 3m6wA-2frxA:
38.1
3m6wA-2frxA:
35.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
3 / 3 VAL A 243
SER A 245
LEU A 192
None
0.71A 3n8xA-2frxA:
undetectable
3n8xA-2frxA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
3 / 3 LYS A 377
ARG A 120
LYS A 310
None
1.43A 3okxA-2frxA:
undetectable
3okxA-2frxA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
5 / 12 PHE A 180
ILE A 135
LEU A 111
LEU A 236
PHE A 188
None
1.18A 3vn2A-2frxA:
undetectable
3vn2A-2frxA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
7 / 12 PRO A 128
ASN A 148
SER A 151
GLY A 177
ASP A 194
PRO A 196
LEU A 228
None
0.75A 4fp9A-2frxA:
29.1
4fp9A-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
7 / 12 PRO A 128
GLY A 129
ASN A 148
SER A 151
GLY A 177
ASP A 194
PRO A 196
None
0.71A 4fp9A-2frxA:
29.1
4fp9A-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
6 / 12 PRO A 128
GLY A 129
LYS A 131
SER A 151
ASP A 194
PRO A 196
None
1.00A 4fp9A-2frxA:
29.1
4fp9A-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
6 / 12 PRO A 128
LYS A 131
SER A 151
ASP A 194
PRO A 196
LEU A 228
None
1.07A 4fp9A-2frxA:
29.1
4fp9A-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
7 / 12 PRO A 128
ASN A 148
SER A 151
GLY A 177
ASP A 194
PRO A 196
LEU A 228
None
0.75A 4fp9C-2frxA:
29.1
4fp9C-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
7 / 12 PRO A 128
GLY A 129
ASN A 148
SER A 151
GLY A 177
ASP A 194
PRO A 196
None
0.71A 4fp9C-2frxA:
29.1
4fp9C-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
6 / 12 PRO A 128
GLY A 129
LYS A 131
SER A 151
ASP A 194
PRO A 196
None
1.00A 4fp9C-2frxA:
29.1
4fp9C-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
6 / 12 PRO A 128
LYS A 131
SER A 151
ASP A 194
PRO A 196
LEU A 228
None
1.08A 4fp9C-2frxA:
29.1
4fp9C-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
6 / 12 PRO A 128
ASN A 148
SER A 151
GLY A 177
PRO A 196
LEU A 228
None
0.74A 4fp9D-2frxA:
29.2
4fp9D-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
6 / 12 PRO A 128
GLY A 129
ASN A 148
SER A 151
ASP A 176
GLY A 177
None
1.10A 4fp9D-2frxA:
29.2
4fp9D-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
6 / 12 PRO A 128
GLY A 129
ASN A 148
SER A 151
GLY A 177
PRO A 196
None
0.61A 4fp9D-2frxA:
29.2
4fp9D-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
5 / 12 PRO A 128
GLY A 129
LYS A 131
SER A 151
PRO A 196
None
0.89A 4fp9D-2frxA:
29.2
4fp9D-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
5 / 12 PRO A 128
LYS A 131
SER A 151
PRO A 196
LEU A 228
None
1.06A 4fp9D-2frxA:
29.2
4fp9D-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
7 / 12 PRO A 128
ASN A 148
SER A 151
GLY A 177
ASP A 194
PRO A 196
LEU A 228
None
0.75A 4fp9F-2frxA:
29.0
4fp9F-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
7 / 12 PRO A 128
GLY A 129
ASN A 148
SER A 151
GLY A 177
ASP A 194
PRO A 196
None
0.72A 4fp9F-2frxA:
29.0
4fp9F-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
6 / 12 PRO A 128
GLY A 129
LYS A 131
SER A 151
ASP A 194
PRO A 196
None
1.00A 4fp9F-2frxA:
29.0
4fp9F-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
6 / 12 PRO A 128
LYS A 131
SER A 151
ASP A 194
PRO A 196
LEU A 228
None
1.07A 4fp9F-2frxA:
29.0
4fp9F-2frxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
6 / 12 PRO A 128
ASN A 148
SER A 151
GLY A 177
PRO A 196
LEU A 228
None
0.73A 4fzvA-2frxA:
28.9
4fzvA-2frxA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
6 / 12 PRO A 128
GLY A 129
ASN A 148
SER A 151
ASP A 176
GLY A 177
None
1.15A 4fzvA-2frxA:
28.9
4fzvA-2frxA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
6 / 12 PRO A 128
GLY A 129
ASN A 148
SER A 151
GLY A 177
PRO A 196
None
0.66A 4fzvA-2frxA:
28.9
4fzvA-2frxA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
5 / 12 PRO A 128
GLY A 129
LYS A 131
SER A 151
PRO A 196
None
0.94A 4fzvA-2frxA:
28.9
4fzvA-2frxA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
4 / 8 SER A 407
ALA A 344
LEU A 405
THR A 345
None
1.01A 4ikjA-2frxA:
undetectable
4ikjB-2frxA:
undetectable
4ikjA-2frxA:
17.16
4ikjB-2frxA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
4 / 8 ALA A 344
LEU A 405
THR A 345
SER A 407
None
0.95A 4ikkA-2frxA:
undetectable
4ikkB-2frxA:
undetectable
4ikkA-2frxA:
17.16
4ikkB-2frxA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
4 / 8 SER A 407
ALA A 344
LEU A 405
THR A 345
None
0.90A 4iklA-2frxA:
undetectable
4iklB-2frxA:
undetectable
4iklA-2frxA:
17.16
4iklB-2frxA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
4 / 4 TYR A 464
GLY A  95
SER A  94
LEU A  93
None
1.44A 5bphC-2frxA:
undetectable
5bphC-2frxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
5 / 12 ALA A 127
PRO A 128
ASP A 176
GLY A 177
ASP A 194
None
1.05A 5wwsA-2frxA:
31.2
5wwsA-2frxA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
5 / 12 ALA A 127
PRO A 128
GLY A 177
ASP A 194
LEU A 228
None
0.60A 5wwsA-2frxA:
31.2
5wwsA-2frxA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
5 / 12 ALA A 127
PRO A 128
ASP A 176
GLY A 177
ASP A 194
None
1.07A 5wwsB-2frxA:
31.1
5wwsB-2frxA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
5 / 12 ALA A 125
PRO A 128
SER A 151
ARG A 178
PRO A 196
None
0.90A 5zvgB-2frxA:
34.6
5zvgB-2frxA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
5 / 12 PRO A 128
LYS A 131
SER A 151
ARG A 178
PRO A 196
None
1.06A 5zvgB-2frxA:
34.6
5zvgB-2frxA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
4 / 7 ILE A 371
LEU A 374
ILE A 135
ALA A 235
None
0.80A 6b5vA-2frxA:
undetectable
6b5vC-2frxA:
undetectable
6b5vA-2frxA:
10.76
6b5vC-2frxA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
4 / 7 ALA A 235
ILE A 371
LEU A 374
ILE A 135
None
0.78A 6b5vA-2frxA:
undetectable
6b5vB-2frxA:
undetectable
6b5vA-2frxA:
10.76
6b5vB-2frxA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
4 / 7 ILE A 371
LEU A 374
ILE A 135
ALA A 235
None
0.81A 6b5vC-2frxA:
undetectable
6b5vD-2frxA:
undetectable
6b5vC-2frxA:
10.76
6b5vD-2frxA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli)
4 / 7 ALA A 235
ILE A 371
LEU A 374
ILE A 135
None
0.80A 6b5vB-2frxA:
undetectable
6b5vD-2frxA:
undetectable
6b5vB-2frxA:
10.76
6b5vD-2frxA:
10.76