SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fsn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 2fsn HYPOTHETICAL PROTEIN
TA0583
(Thermoplasma
acidophilum) 		5 / 10 GLY A 154
ASN A 161
LEU A 185
ASP A 183
ALA A 321
 None
 1.23A 1fpqA-2fsnA:
undetectable		 1fpqA-2fsnA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 2fsn HYPOTHETICAL PROTEIN
TA0583
(Thermoplasma
acidophilum) 		5 / 8 ILE A 297
LEU A 280
ILE A 175
VAL A 184
ILE A 266
 None
 1.32A 1linA-2fsnA:
undetectable		 1linA-2fsnA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2fsn HYPOTHETICAL PROTEIN
TA0583
(Thermoplasma
acidophilum) 		3 / 3 LYS A  43
TYR A  57
PRO A  44
 None
 1.41A 2j9cC-2fsnA:
undetectable		 2j9cC-2fsnA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)		 2fsn HYPOTHETICAL PROTEIN
TA0583
(Thermoplasma
acidophilum) 		5 / 11 ASP A 191
THR A 278
GLY A 172
THR A 186
VAL A 195
 None
 1.44A 2uvnB-2fsnA:
undetectable		 2uvnB-2fsnA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2fsn HYPOTHETICAL PROTEIN
TA0583
(Thermoplasma
acidophilum) 		4 / 7 THR A 182
ILE A 204
GLY A 205
ILE A 290
 None
 0.81A 2y7wC-2fsnA:
undetectable		 2y7wC-2fsnA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 2fsn HYPOTHETICAL PROTEIN
TA0583
(Thermoplasma
acidophilum) 		5 / 12 LEU A 255
GLY A 205
ILE A 175
GLY A 284
ILE A 290
 None
None
None
ADP  A 328 ( 4.3A)
None
 0.99A 3cyxA-2fsnA:
undetectable		 3cyxA-2fsnA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2fsn HYPOTHETICAL PROTEIN
TA0583
(Thermoplasma
acidophilum) 		4 / 8 SER A 199
ASP A 176
ASP A 114
TYR A 318
 None
MG  A 327 ( 4.2A)
None
None
 1.08A 3havA-2fsnA:
undetectable		 3havA-2fsnA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 2fsn HYPOTHETICAL PROTEIN
TA0583
(Thermoplasma
acidophilum) 		5 / 12 LEU A 255
GLY A 205
ILE A 175
GLY A 284
ILE A 290
 None
None
None
ADP  A 328 ( 4.3A)
None
 0.95A 3nduB-2fsnA:
undetectable		 3nduB-2fsnA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)		 2fsn HYPOTHETICAL PROTEIN
TA0583
(Thermoplasma
acidophilum) 		5 / 12 LEU A 255
GLY A 205
ILE A 175
GLY A 284
ILE A 290
 None
None
None
ADP  A 328 ( 4.3A)
None
 0.90A 3nu3A-2fsnA:
undetectable		 3nu3A-2fsnA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2fsn HYPOTHETICAL PROTEIN
TA0583
(Thermoplasma
acidophilum) 		3 / 3 GLY A  92
ILE A  16
VAL A  15
 None
 0.45A 3nv6A-2fsnA:
undetectable		 3nv6A-2fsnA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 2fsn HYPOTHETICAL PROTEIN
TA0583
(Thermoplasma
acidophilum) 		5 / 12 LEU A 255
GLY A 205
ILE A 175
GLY A 284
ILE A 290
 None
None
None
ADP  A 328 ( 4.3A)
None
 0.94A 3oxxC-2fsnA:
undetectable		 3oxxC-2fsnA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_1
(PROTEASE)		 2fsn HYPOTHETICAL PROTEIN
TA0583
(Thermoplasma
acidophilum) 		5 / 12 LEU A 255
GLY A 205
ILE A 175
GLY A 284
ILE A 290
 None
None
None
ADP  A 328 ( 4.3A)
None
 1.00A 3pwrA-2fsnA:
undetectable		 3pwrA-2fsnA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 2fsn HYPOTHETICAL PROTEIN
TA0583
(Thermoplasma
acidophilum) 		5 / 12 LEU A 255
GLY A 205
ILE A 175
GLY A 284
ILE A 290
 None
None
None
ADP  A 328 ( 4.3A)
None
 0.97A 3tkgA-2fsnA:
undetectable		 3tkgA-2fsnA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 2fsn HYPOTHETICAL PROTEIN
TA0583
(Thermoplasma
acidophilum) 		4 / 5 ASP A 176
VAL A 177
GLY A 178
ASP A  72
 MG  A 327 ( 4.2A)
None
ADP  A 328 (-3.4A)
MG  A 327 (-3.5A)
 1.10A 3w9tA-2fsnA:
undetectable		 3w9tA-2fsnA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 2fsn HYPOTHETICAL PROTEIN
TA0583
(Thermoplasma
acidophilum) 		4 / 5 ASP A 176
VAL A 177
GLY A 178
ASP A  72
 MG  A 327 ( 4.2A)
None
ADP  A 328 (-3.4A)
MG  A 327 (-3.5A)
 1.09A 3w9tB-2fsnA:
undetectable		 3w9tB-2fsnA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 2fsn HYPOTHETICAL PROTEIN
TA0583
(Thermoplasma
acidophilum) 		4 / 5 ASP A 176
VAL A 177
GLY A 178
ASP A  72
 MG  A 327 ( 4.2A)
None
ADP  A 328 (-3.4A)
MG  A 327 (-3.5A)
 1.09A 3w9tF-2fsnA:
undetectable		 3w9tF-2fsnA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 2fsn HYPOTHETICAL PROTEIN
TA0583
(Thermoplasma
acidophilum) 		5 / 12 LEU A 255
GLY A 205
ILE A 175
GLY A 284
ILE A 290
 None
None
None
ADP  A 328 ( 4.3A)
None
 0.92A 4jecB-2fsnA:
undetectable		 4jecB-2fsnA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2fsn HYPOTHETICAL PROTEIN
TA0583
(Thermoplasma
acidophilum) 		4 / 6 VAL A 277
THR A 301
LEU A 198
GLU A 193
 None
 0.95A 5tudD-2fsnA:
undetectable		 5tudD-2fsnA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 2fsn HYPOTHETICAL PROTEIN
TA0583
(Thermoplasma
acidophilum) 		4 / 8 GLY A  58
ILE A  66
GLN A  70
ASP A 228
 None
 0.95A 5vlmH-2fsnA:
undetectable		 5vlmH-2fsnA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 2fsn HYPOTHETICAL PROTEIN
TA0583
(Thermoplasma
acidophilum) 		5 / 12 LEU A 255
GLY A 205
ILE A 175
GLY A 284
ILE A 290
 None
None
None
ADP  A 328 ( 4.3A)
None
 0.91A 6dh3B-2fsnA:
undetectable		 6dh3B-2fsnA:
14.38