SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fsr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 2fsr ACETYLTRANSFERASE
(Agrobacterium
fabrum) 		3 / 3 GLU A  75
ILE A  77
ARG A  34
 None
 0.64A 1cd2A-2fsrA:
undetectable		 1cd2A-2fsrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUF_B_AZ1B503_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 2fsr ACETYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 6 SER A  35
ARG A  27
TYR A  26
TYR A  42
 None
 1.44A 1tufA-2fsrA:
undetectable
1tufB-2fsrA:
undetectable		 1tufA-2fsrA:
16.09
1tufB-2fsrA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 2fsr ACETYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 8 TRP A  95
TYR A 165
GLU A  92
GLY A  94
 None
 1.13A 2ha4A-2fsrA:
undetectable		 2ha4A-2fsrA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 2fsr ACETYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 7 TRP A  95
TYR A 165
GLU A  92
GLY A  94
 None
 1.16A 2ha4B-2fsrA:
undetectable		 2ha4B-2fsrA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 2fsr ACETYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 5 ALA A 111
TRP A  95
LEU A  96
ALA A 110
 None
 1.12A 2jstA-2fsrA:
undetectable
2jstB-2fsrA:
undetectable		 2jstA-2fsrA:
17.24
2jstB-2fsrA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2fsr ACETYLTRANSFERASE
(Agrobacterium
fabrum) 		3 / 3 HIS A 101
ILE A  68
LEU A  96
 FMT  A 301 (-3.9A)
None
None
 0.71A 2kceA-2fsrA:
undetectable		 2kceA-2fsrA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2fsr ACETYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 6 LEU A  93
TYR A 130
LEU A 127
TYR A 165
 None
 1.16A 4f3tA-2fsrA:
undetectable		 4f3tA-2fsrA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 2fsr ACETYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 12 GLY A  94
GLY A  81
SER A 129
TYR A 130
VAL A 131
 None
 1.24A 4f84A-2fsrA:
undetectable		 4f84A-2fsrA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 2fsr ACETYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 10 PHE A 119
GLY A  94
ALA A 113
ASP A 116
ALA A 118
 None
 1.24A 4wnuD-2fsrA:
undetectable		 4wnuD-2fsrA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2fsr ACETYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 10 ILE A  80
GLY A  78
LEU A  97
LEU A  13
LEU A  70
 None
None
None
None
FMT  A 301 (-4.6A)
 1.21A 5fhzC-2fsrA:
undetectable		 5fhzC-2fsrA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2fsr ACETYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 5 TYR A 165
GLY A 147
THR A 148
GLY A 100
 None
 0.81A 5jlcA-2fsrA:
undetectable		 5jlcA-2fsrA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2fsr ACETYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 5 LEU A  93
TYR A 130
LEU A 127
TYR A 165
 None
 1.13A 5ki6A-2fsrA:
undetectable		 5ki6A-2fsrA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 2fsr ACETYLTRANSFERASE
(Agrobacterium
fabrum) 		3 / 3 LYS A  91
HIS A  63
HIS A  84
 None
 1.13A 5oexA-2fsrA:
undetectable		 5oexA-2fsrA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 2fsr ACETYLTRANSFERASE
(Agrobacterium
fabrum) 		3 / 3 LYS A  91
HIS A  63
HIS A  84
 None
 1.12A 5oexB-2fsrA:
undetectable		 5oexB-2fsrA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 2fsr ACETYLTRANSFERASE
(Agrobacterium
fabrum) 		3 / 3 LYS A  91
HIS A  63
HIS A  84
 None
 1.14A 5oexC-2fsrA:
undetectable		 5oexC-2fsrA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 2fsr ACETYLTRANSFERASE
(Agrobacterium
fabrum) 		3 / 3 LYS A  91
HIS A  63
HIS A  84
 None
 1.18A 5oexD-2fsrA:
undetectable		 5oexD-2fsrA:
15.89