SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fsv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)
2fsv NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Rhodospirillum
rubrum)
5 / 12 VAL C  78
ALA C 157
MET C  43
VAL C  52
ALA C  83
None
0.94A 1sa1A-2fsvC:
3.4
1sa1B-2fsvC:
3.8
1sa1A-2fsvC:
17.79
1sa1B-2fsvC:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)
2fsv NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Rhodospirillum
rubrum)
5 / 12 VAL C  78
ALA C 157
MET C  43
VAL C  52
ALA C  83
None
0.95A 1sa1C-2fsvC:
3.5
1sa1D-2fsvC:
3.2
1sa1C-2fsvC:
17.79
1sa1D-2fsvC:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)
2fsv NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Rhodospirillum
rubrum)
3 / 3 SER C 169
HIS C  85
ASP C 153
None
0.73A 2wa2B-2fsvC:
2.1
2wa2B-2fsvC:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)
2fsv NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Rhodospirillum
rubrum)
5 / 7 VAL C 124
ILE C  42
ALA C  46
GLY C 158
THR C 159
None
1.06A 2xrzB-2fsvC:
undetectable
2xrzB-2fsvC:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)
2fsv NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Rhodospirillum
rubrum)
4 / 6 PHE C 119
ILE C  50
ALA C 125
ALA C 130
None
None
None
NAP  C 700 (-3.4A)
1.07A 3mdrB-2fsvC:
undetectable
3mdrB-2fsvC:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
2fsv NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Rhodospirillum
rubrum)
5 / 12 GLY C 129
THR C 134
ILE C 163
ASP C 190
ALA C 191
NAP  C 700 (-3.8A)
None
None
NAP  C 700 (-3.7A)
NAP  C 700 (-3.4A)
1.10A 3nvkI-2fsvC:
3.7
3nvkI-2fsvC:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)
2fsv NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Rhodospirillum
rubrum)
3 / 3 LEU C  66
ASP C  71
ILE C  84
None
0.68A 4xi3D-2fsvC:
undetectable
4xi3D-2fsvC:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)
2fsv NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Rhodospirillum
rubrum)
5 / 12 GLY C  54
GLY C 129
ALA C  83
ILE C  84
ALA C  60
NAP  C 700 ( 3.7A)
NAP  C 700 (-3.8A)
None
None
NAP  C 700 (-3.6A)
1.21A 5bw4B-2fsvC:
3.2
5bw4B-2fsvC:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)
2fsv NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Rhodospirillum
rubrum)
5 / 12 GLY C  56
TYR C 171
ILE C 163
ALA C  62
ASP C 190
NAP  C 700 (-3.4A)
NAP  C 700 (-3.9A)
None
None
NAP  C 700 (-3.7A)
0.97A 5kvaA-2fsvC:
3.5
5kvaA-2fsvC:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)
2fsv NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Rhodospirillum
rubrum)
5 / 12 GLY C  56
TYR C 171
ILE C 163
ALA C  62
ASP C 190
NAP  C 700 (-3.4A)
NAP  C 700 (-3.9A)
None
None
NAP  C 700 (-3.7A)
0.95A 5kvaB-2fsvC:
3.3
5kvaB-2fsvC:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)
2fsv NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Rhodospirillum
rubrum)
5 / 10 PHE C 126
LEU C 161
GLY C 129
ILE C 128
ILE C 198
None
None
NAP  C 700 (-3.8A)
None
None
1.09A 6ebpD-2fsvC:
undetectable
6ebpD-2fsvC:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)
2fsv NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Rhodospirillum
rubrum)
4 / 6 VAL C 154
ASN C 135
PRO C 136
ILE C 151
None
1.24A 6h7uA-2fsvC:
undetectable
6h7uA-2fsvC:
16.25