SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fsx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GMK_D_DVAD8_0 (GRAMICIDIN A)	2fsx	COG0607: RHODANESE-RELATED SULFURTRANSFERASE (Mycobacterium tuberculosis)	3 / 3	TRP A 137 VAL A 133 TRP A 130	None	1.14A	1gmkC-2fsxA: undetectable 1gmkD-2fsxA: undetectable	1gmkC-2fsxA: 7.97 1gmkD-2fsxA: 7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XCT_G_CPFG1020_1 (DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A)	2fsx	COG0607: RHODANESE-RELATED SULFURTRANSFERASE (Mycobacterium tuberculosis)	3 / 3	ARG A 131 GLY A 134 SER A 43	None	0.64A	2xctB-2fsxA: 2.9	2xctB-2fsxA: 11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4H1N_A_CGEA505_1 (CYTOCHROME P450 2B4)	2fsx	COG0607: RHODANESE-RELATED SULFURTRANSFERASE (Mycobacterium tuberculosis)	5 / 11	ILE A 72 ALA A 100 ALA A 97 VAL A 27 VAL A 49	None None None BR A 209 (-4.7A) BR A 202 ( 4.0A)	1.14A	4h1nA-2fsxA: undetectable	4h1nA-2fsxA: 15.66