SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ft3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 2ft3 BIGLYCAN
(Bos
taurus) 		6 / 12 ILE A 135
ILE A  93
LEU A 121
PRO A 122
LEU A 128
ILE A 117
 None
 1.42A 1df7A-2ft3A:
undetectable		 1df7A-2ft3A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 2ft3 BIGLYCAN
(Bos
taurus) 		5 / 11 ILE A 135
ILE A  93
LEU A 121
PRO A 122
ILE A 117
 None
 1.10A 1dg5A-2ft3A:
undetectable		 1dg5A-2ft3A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2ft3 BIGLYCAN
(Bos
taurus) 		4 / 4 ILE A 152
LEU A 159
VAL A 138
ILE A 117
 None
 0.89A 1fm6D-2ft3A:
undetectable		 1fm6D-2ft3A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 2ft3 BIGLYCAN
(Bos
taurus) 		4 / 7 GLN A  62
LEU A  69
SER A 110
ASN A 112
 None
 1.12A 1ig3A-2ft3A:
undetectable
1ig3B-2ft3A:
undetectable		 1ig3A-2ft3A:
21.13
1ig3B-2ft3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 2ft3 BIGLYCAN
(Bos
taurus) 		5 / 12 SER A 236
ASN A 203
LEU A 222
ILE A 232
LEU A 237
 None
 1.11A 1lhuA-2ft3A:
undetectable		 1lhuA-2ft3A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 2ft3 BIGLYCAN
(Bos
taurus) 		5 / 11 LEU A  80
ASN A 112
ILE A  90
LEU A  69
PHE A  98
 None
 1.23A 1tw4A-2ft3A:
undetectable		 1tw4A-2ft3A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 2ft3 BIGLYCAN
(Bos
taurus) 		4 / 4 ILE A 232
ASP A 262
LEU A 266
ARG A 255
 None
 1.03A 2a7qA-2ft3A:
undetectable		 2a7qA-2ft3A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 2ft3 BIGLYCAN
(Bos
taurus) 		4 / 5 ILE A 117
PRO A 119
PHE A  98
ILE A 109
 None
 1.14A 2hjhA-2ft3A:
undetectable		 2hjhA-2ft3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 2ft3 BIGLYCAN
(Bos
taurus) 		4 / 7 ASP A 283
THR A 315
ILE A 325
PHE A 327
 None
 1.24A 2jc9A-2ft3A:
undetectable		 2jc9A-2ft3A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 2ft3 BIGLYCAN
(Bos
taurus) 		3 / 3 LEU A  83
LEU A 114
PHE A  74
 None
 0.69A 2pgrA-2ft3A:
undetectable		 2pgrA-2ft3A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 2ft3 BIGLYCAN
(Bos
taurus) 		5 / 11 LEU A 177
LEU A 191
ILE A 179
PHE A 143
LEU A 159
 None
 1.16A 2q6hA-2ft3A:
undetectable		 2q6hA-2ft3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 2ft3 BIGLYCAN
(Bos
taurus) 		5 / 11 LEU A 177
LEU A 191
ILE A 179
PHE A 143
LEU A 159
 None
 1.17A 2q72A-2ft3A:
undetectable		 2q72A-2ft3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 2ft3 BIGLYCAN
(Bos
taurus) 		5 / 12 LEU A 177
LEU A 191
ILE A 179
PHE A 143
LEU A 159
 None
 1.17A 2qb4A-2ft3A:
undetectable		 2qb4A-2ft3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 2ft3 BIGLYCAN
(Bos
taurus) 		5 / 11 LEU A 177
LEU A 191
ILE A 179
PHE A 143
LEU A 159
 None
 1.16A 2qeiA-2ft3A:
undetectable		 2qeiA-2ft3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 2ft3 BIGLYCAN
(Bos
taurus) 		5 / 11 LEU A 177
LEU A 191
ILE A 179
PHE A 143
LEU A 159
 None
 1.16A 2qjuA-2ft3A:
undetectable		 2qjuA-2ft3A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2ft3 BIGLYCAN
(Bos
taurus) 		5 / 12 ILE A 208
ASP A 212
GLY A 186
ASN A 161
ILE A 205
 None
 1.25A 2ycjA-2ft3A:
undetectable		 2ycjA-2ft3A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2ft3 BIGLYCAN
(Bos
taurus) 		5 / 12 TYR A 216
ILE A 187
PHE A 169
LEU A 177
LEU A 219
 None
 1.15A 3em0B-2ft3A:
undetectable		 3em0B-2ft3A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2ft3 BIGLYCAN
(Bos
taurus) 		5 / 12 LEU A 191
LEU A 219
LEU A 222
GLY A 223
HIS A 199
 None
 1.38A 3g1uB-2ft3A:
undetectable		 3g1uB-2ft3A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 2ft3 BIGLYCAN
(Bos
taurus) 		5 / 10 GLY A 223
GLU A 197
LEU A 200
LEU A 224
ILE A 187
 None
 1.21A 3kvrA-2ft3A:
undetectable		 3kvrA-2ft3A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 2ft3 BIGLYCAN
(Bos
taurus) 		5 / 10 GLY A 223
GLU A 197
LEU A 200
LEU A 224
ILE A 187
 None
 1.20A 3kvrB-2ft3A:
undetectable		 3kvrB-2ft3A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2ft3 BIGLYCAN
(Bos
taurus) 		4 / 7 LEU A 253
ASN A 251
GLY A 186
ILE A 187
 None
 0.74A 3spkB-2ft3A:
undetectable		 3spkB-2ft3A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 2ft3 BIGLYCAN
(Bos
taurus) 		5 / 11 LEU A 200
ILE A 179
ARG A 129
LEU A 191
LEU A 219
 None
 1.14A 4dm8A-2ft3A:
undetectable		 4dm8A-2ft3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 2ft3 BIGLYCAN
(Bos
taurus) 		5 / 12 ILE A 135
ILE A  93
LEU A 121
LEU A 128
ILE A 117
 None
 1.01A 4m2xC-2ft3A:
undetectable		 4m2xC-2ft3A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ft3 BIGLYCAN
(Bos
taurus) 		4 / 6 PHE A 316
ILE A 325
ARG A 322
VAL A 306
 None
 1.33A 4mk4B-2ft3A:
undetectable		 4mk4B-2ft3A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2ft3 BIGLYCAN
(Bos
taurus) 		5 / 8 ILE A 187
LEU A 213
ILE A 208
ILE A 229
ASN A 251
 None
 1.26A 5numA-2ft3A:
undetectable		 5numA-2ft3A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2ft3 BIGLYCAN
(Bos
taurus) 		5 / 8 LEU A 213
ILE A 208
ILE A 229
ASN A 227
SER A 180
 None
 1.20A 5numA-2ft3A:
undetectable		 5numA-2ft3A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2ft3 BIGLYCAN
(Bos
taurus) 		5 / 12 ASP A 170
LEU A 200
LEU A 184
LEU A 198
LEU A 174
 None
 1.07A 6ew0B-2ft3A:
undetectable		 6ew0B-2ft3A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 2ft3 BIGLYCAN
(Bos
taurus) 		5 / 12 ASP A 170
LEU A 200
LEU A 184
LEU A 198
LEU A 174
 None
 1.07A 6ew0D-2ft3A:
undetectable		 6ew0D-2ft3A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 2ft3 BIGLYCAN
(Bos
taurus) 		5 / 12 ASP A 170
LEU A 200
LEU A 184
LEU A 198
LEU A 174
 None
 1.07A 6ew0H-2ft3A:
undetectable		 6ew0H-2ft3A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 2ft3 BIGLYCAN
(Bos
taurus) 		5 / 12 ASP A 170
LEU A 200
LEU A 184
LEU A 198
LEU A 174
 None
 1.07A 6ew0I-2ft3A:
undetectable		 6ew0I-2ft3A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 2ft3 BIGLYCAN
(Bos
taurus) 		5 / 9 LEU A 213
PRO A 188
SER A 180
LEU A 184
ILE A 205
 None
 1.00A 6fdyU-2ft3A:
undetectable		 6fdyU-2ft3A:
21.99