SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ftp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.24A 1c9sA-2ftpA:
undetectable
1c9sK-2ftpA:
undetectable		 1c9sA-2ftpA:
12.42
1c9sK-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.25A 1c9sB-2ftpA:
undetectable
1c9sC-2ftpA:
undetectable		 1c9sB-2ftpA:
12.42
1c9sC-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.23A 1c9sD-2ftpA:
undetectable
1c9sE-2ftpA:
undetectable		 1c9sD-2ftpA:
12.42
1c9sE-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.25A 1c9sE-2ftpA:
undetectable
1c9sF-2ftpA:
undetectable		 1c9sE-2ftpA:
12.42
1c9sF-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.23A 1c9sG-2ftpA:
undetectable
1c9sH-2ftpA:
undetectable		 1c9sG-2ftpA:
12.42
1c9sH-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.23A 1c9sH-2ftpA:
undetectable
1c9sI-2ftpA:
undetectable		 1c9sH-2ftpA:
12.42
1c9sI-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.23A 1c9sO-2ftpA:
undetectable
1c9sP-2ftpA:
undetectable		 1c9sO-2ftpA:
12.42
1c9sP-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  78
TYR A  44
TYR A 172
SER A 175
GLU A  46
 None
 1.22A 1dy4A-2ftpA:
undetectable		 1dy4A-2ftpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKB_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A  35
GLN A  23
GLU A  26
ILE A 280
ILE A  45
 None
 1.20A 1fkbA-2ftpA:
undetectable		 1fkbA-2ftpA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.24A 1gtfC-2ftpA:
undetectable
1gtfD-2ftpA:
undetectable		 1gtfC-2ftpA:
12.42
1gtfD-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.24A 1gtfH-2ftpA:
undetectable
1gtfI-2ftpA:
undetectable		 1gtfH-2ftpA:
12.42
1gtfI-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.23A 1gtfI-2ftpA:
undetectable
1gtfJ-2ftpA:
undetectable		 1gtfI-2ftpA:
12.42
1gtfJ-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.26A 1gtfL-2ftpA:
undetectable
1gtfV-2ftpA:
undetectable		 1gtfL-2ftpA:
12.42
1gtfV-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 8 VAL A 268
VAL A 250
VAL A 255
ILE A 264
LEU A   9
 None
 1.39A 1igxA-2ftpA:
undetectable		 1igxA-2ftpA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A  11
GLY A  48
ALA A  99
PHE A  50
PHE A  66
 None
None
None
GOL  A2000 (-4.9A)
None
 1.17A 1nw3A-2ftpA:
undetectable		 1nw3A-2ftpA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		4 / 8 GLU A  46
VAL A  12
GLU A 173
ASP A 231
 None
 1.24A 1s3zA-2ftpA:
undetectable
1s3zB-2ftpA:
undetectable		 1s3zA-2ftpA:
19.87
1s3zB-2ftpA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_A_TRPA81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.20A 1utdA-2ftpA:
undetectable
1utdB-2ftpA:
undetectable		 1utdA-2ftpA:
12.42
1utdB-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_M_TRPM81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.23A 1utdM-2ftpA:
undetectable
1utdN-2ftpA:
undetectable		 1utdM-2ftpA:
12.42
1utdN-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		4 / 8 VAL A  47
GLY A  48
VAL A  27
ILE A  31
 None
 0.79A 2a1mB-2ftpA:
undetectable		 2a1mB-2ftpA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A  16
ILE A 142
VAL A 138
 NA  A3000 (-2.9A)
None
None
 0.70A 2avvD-2ftpA:
undetectable		 2avvD-2ftpA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 267
ILE A 264
ASP A 269
VAL A   7
LEU A  42
 None
 0.94A 2yqzA-2ftpA:
undetectable		 2yqzA-2ftpA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 267
ILE A 264
ASP A 269
VAL A   7
LEU A  42
 None
 0.95A 2yqzB-2ftpA:
undetectable		 2yqzB-2ftpA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A  16
THR A 266
GLU A  11
 NA  A3000 (-2.9A)
None
None
 0.76A 2zifB-2ftpA:
undetectable		 2zifB-2ftpA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A 233
GLY A 245
GLU A  21
ASN A  20
 None
 0.90A 3aodA-2ftpA:
undetectable		 3aodA-2ftpA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		4 / 6 GLN A 168
LEU A 166
GLU A 165
LEU A 121
 None
 0.90A 3h5gA-2ftpA:
undetectable
3h5gC-2ftpA:
undetectable		 3h5gA-2ftpA:
6.95
3h5gC-2ftpA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		4 / 8 PHE A  87
GLU A  92
SER A  93
VAL A  95
 None
 0.92A 3jx1A-2ftpA:
undetectable
3jx1B-2ftpA:
undetectable		 3jx1A-2ftpA:
20.78
3jx1B-2ftpA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 297
ALA A  40
VAL A 234
GLY A 236
ALA A 235
 None
 1.08A 3ln1D-2ftpA:
undetectable		 3ln1D-2ftpA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 236
GLY A 289
ASP A 231
ASP A 254
LEU A 259
 None
 1.01A 3m6vA-2ftpA:
undetectable		 3m6vA-2ftpA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 236
GLY A 289
ASP A 231
ASP A 254
LEU A 259
 None
 1.00A 3m6vB-2ftpA:
undetectable		 3m6vB-2ftpA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		4 / 7 PHE A  87
GLU A  92
SER A  93
VAL A  95
 None
 0.95A 3n61A-2ftpA:
undetectable
3n61B-2ftpA:
undetectable		 3n61A-2ftpA:
20.78
3n61B-2ftpA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 274
LEU A 273
GLY A 236
ALA A 235
SER A 290
 None
 1.04A 3n8zA-2ftpA:
undetectable		 3n8zA-2ftpA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		4 / 8 PHE A  87
GLU A  92
SER A  93
VAL A  95
 None
 0.96A 3nlrA-2ftpA:
undetectable
3nlrB-2ftpA:
undetectable		 3nlrA-2ftpA:
20.78
3nlrB-2ftpA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		4 / 8 PHE A  87
GLU A  92
SER A  93
VAL A  95
 None
 0.93A 3nlyA-2ftpA:
undetectable
3nlyB-2ftpA:
undetectable		 3nlyA-2ftpA:
20.78
3nlyB-2ftpA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  91
GLY A  86
ALA A  81
ALA A  79
LEU A  84
 None
 1.15A 3p5nB-2ftpA:
undetectable		 3p5nB-2ftpA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 274
LEU A 273
GLY A 236
ALA A 235
SER A 290
 None
 1.04A 3pghD-2ftpA:
undetectable		 3pghD-2ftpA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A  11
GLY A  48
ALA A  99
PHE A  50
PHE A  66
 None
None
None
GOL  A2000 (-4.9A)
None
 1.18A 3qowA-2ftpA:
undetectable		 3qowA-2ftpA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		4 / 8 PHE A  87
GLU A  92
SER A  93
VAL A  95
 None
 0.93A 3rqlA-2ftpA:
undetectable
3rqlB-2ftpA:
undetectable		 3rqlA-2ftpA:
20.78
3rqlB-2ftpA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 274
LEU A 273
GLY A 236
ALA A 235
SER A 290
 None
 1.12A 3rr3C-2ftpA:
undetectable		 3rr3C-2ftpA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 274
LEU A 273
GLY A 236
ALA A 235
SER A 290
 None
 1.12A 3rr3D-2ftpA:
undetectable		 3rr3D-2ftpA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		4 / 5 SER A 120
ARG A 123
PRO A 126
VAL A 125
 None
 1.35A 3sufC-2ftpA:
undetectable		 3sufC-2ftpA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		4 / 8 PHE A  87
GLU A  92
SER A  93
VAL A  95
 None
 0.98A 4capA-2ftpA:
undetectable
4capB-2ftpA:
undetectable		 4capA-2ftpA:
20.78
4capB-2ftpA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		4 / 8 PHE A  87
GLU A  92
SER A  93
VAL A  95
 None
 0.93A 4d32A-2ftpA:
undetectable
4d32B-2ftpA:
undetectable		 4d32A-2ftpA:
20.78
4d32B-2ftpA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		4 / 7 GLU A  46
GLU A  97
GLU A 173
ARG A 137
 None
 0.99A 4mi4B-2ftpA:
1.3
4mi4C-2ftpA:
1.2		 4mi4B-2ftpA:
21.36
4mi4C-2ftpA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		4 / 8 GLU A  46
GLU A  97
GLU A 173
ARG A 137
 None
 1.00A 4mj8B-2ftpA:
undetectable
4mj8C-2ftpA:
1.2		 4mj8B-2ftpA:
20.59
4mj8C-2ftpA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 274
LEU A 273
GLY A 236
ALA A 235
SER A 290
 None
 1.07A 4otyA-2ftpA:
undetectable		 4otyA-2ftpA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 274
LEU A 273
GLY A 236
ALA A 235
SER A 290
 None
 1.09A 4otyB-2ftpA:
undetectable		 4otyB-2ftpA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		4 / 6 THR A  76
ALA A  78
LEU A  80
SER A  49
 None
 0.84A 4pwjA-2ftpA:
undetectable		 4pwjA-2ftpA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		4 / 7 THR A  76
ALA A  78
LEU A  80
SER A  49
 None
 0.82A 4pwjB-2ftpA:
undetectable		 4pwjB-2ftpA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 274
LEU A 273
GLY A 236
ALA A 235
SER A 290
 None
 1.18A 4rrwA-2ftpA:
undetectable		 4rrwA-2ftpA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 274
LEU A 273
GLY A 236
ALA A 235
SER A 290
 None
 1.19A 4rrwB-2ftpA:
undetectable		 4rrwB-2ftpA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 274
LEU A 273
GLY A 236
ALA A 235
SER A 290
 None
 1.18A 4rrzA-2ftpA:
undetectable		 4rrzA-2ftpA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 274
LEU A 273
GLY A 236
ALA A 235
SER A 290
 None
 1.19A 4rrzB-2ftpA:
undetectable		 4rrzB-2ftpA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		4 / 8 PHE A  87
GLU A  92
SER A  93
VAL A  95
 None
 0.94A 4v3yA-2ftpA:
undetectable
4v3yB-2ftpA:
undetectable		 4v3yA-2ftpA:
20.78
4v3yB-2ftpA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		4 / 7 THR A  76
ALA A  78
LEU A  80
SER A  49
 None
 0.85A 5bojB-2ftpA:
undetectable		 5bojB-2ftpA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.21A 5eeuJ-2ftpA:
undetectable
5eeuK-2ftpA:
undetectable		 5eeuJ-2ftpA:
12.42
5eeuK-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.22A 5eeuT-2ftpA:
undetectable
5eeuU-2ftpA:
undetectable		 5eeuT-2ftpA:
12.42
5eeuU-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.25A 5eeuU-2ftpA:
undetectable
5eeuV-2ftpA:
undetectable		 5eeuU-2ftpA:
12.42
5eeuV-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.21A 5eevJ-2ftpA:
undetectable
5eevK-2ftpA:
undetectable		 5eevJ-2ftpA:
12.42
5eevK-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.22A 5eevT-2ftpA:
undetectable
5eevU-2ftpA:
undetectable		 5eevT-2ftpA:
12.42
5eevU-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.25A 5eevU-2ftpA:
undetectable
5eevV-2ftpA:
undetectable		 5eevU-2ftpA:
12.42
5eevV-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.21A 5eewJ-2ftpA:
undetectable
5eewK-2ftpA:
undetectable		 5eewJ-2ftpA:
12.42
5eewK-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.22A 5eewT-2ftpA:
undetectable
5eewU-2ftpA:
undetectable		 5eewT-2ftpA:
12.42
5eewU-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.25A 5eewU-2ftpA:
undetectable
5eewV-2ftpA:
undetectable		 5eewU-2ftpA:
12.42
5eewV-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.21A 5eexJ-2ftpA:
undetectable
5eexK-2ftpA:
undetectable		 5eexJ-2ftpA:
12.42
5eexK-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.23A 5eexQ-2ftpA:
undetectable
5eexR-2ftpA:
undetectable		 5eexQ-2ftpA:
12.42
5eexR-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.22A 5eexT-2ftpA:
undetectable
5eexU-2ftpA:
undetectable		 5eexT-2ftpA:
12.42
5eexU-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.25A 5eexU-2ftpA:
undetectable
5eexV-2ftpA:
undetectable		 5eexU-2ftpA:
12.42
5eexV-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.21A 5eeyJ-2ftpA:
undetectable
5eeyK-2ftpA:
undetectable		 5eeyJ-2ftpA:
12.42
5eeyK-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.22A 5eeyQ-2ftpA:
undetectable
5eeyR-2ftpA:
undetectable		 5eeyQ-2ftpA:
12.42
5eeyR-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.22A 5eeyT-2ftpA:
undetectable
5eeyU-2ftpA:
undetectable		 5eeyT-2ftpA:
12.42
5eeyU-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.26A 5eeyU-2ftpA:
undetectable
5eeyV-2ftpA:
undetectable		 5eeyU-2ftpA:
12.42
5eeyV-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.21A 5eezJ-2ftpA:
undetectable
5eezK-2ftpA:
undetectable		 5eezJ-2ftpA:
12.42
5eezK-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.22A 5eezQ-2ftpA:
undetectable
5eezR-2ftpA:
undetectable		 5eezQ-2ftpA:
12.42
5eezR-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.22A 5eezT-2ftpA:
undetectable
5eezU-2ftpA:
undetectable		 5eezT-2ftpA:
12.42
5eezU-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.25A 5eezU-2ftpA:
undetectable
5eezV-2ftpA:
undetectable		 5eezU-2ftpA:
12.42
5eezV-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.21A 5ef0J-2ftpA:
undetectable
5ef0K-2ftpA:
undetectable		 5ef0J-2ftpA:
12.42
5ef0K-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.22A 5ef0Q-2ftpA:
undetectable
5ef0R-2ftpA:
undetectable		 5ef0Q-2ftpA:
12.42
5ef0R-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.22A 5ef0T-2ftpA:
undetectable
5ef0U-2ftpA:
undetectable		 5ef0T-2ftpA:
12.42
5ef0U-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.25A 5ef0U-2ftpA:
undetectable
5ef0V-2ftpA:
undetectable		 5ef0U-2ftpA:
12.42
5ef0V-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.21A 5ef1J-2ftpA:
undetectable
5ef1K-2ftpA:
undetectable		 5ef1J-2ftpA:
12.42
5ef1K-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.23A 5ef1Q-2ftpA:
undetectable
5ef1R-2ftpA:
undetectable		 5ef1Q-2ftpA:
12.42
5ef1R-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.22A 5ef1T-2ftpA:
undetectable
5ef1U-2ftpA:
undetectable		 5ef1T-2ftpA:
12.42
5ef1U-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.25A 5ef1U-2ftpA:
undetectable
5ef1V-2ftpA:
undetectable		 5ef1U-2ftpA:
12.42
5ef1V-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.21A 5ef2J-2ftpA:
undetectable
5ef2K-2ftpA:
undetectable		 5ef2J-2ftpA:
12.42
5ef2K-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.23A 5ef2Q-2ftpA:
undetectable
5ef2R-2ftpA:
undetectable		 5ef2Q-2ftpA:
12.42
5ef2R-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.22A 5ef2T-2ftpA:
undetectable
5ef2U-2ftpA:
undetectable		 5ef2T-2ftpA:
12.42
5ef2U-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.25A 5ef2U-2ftpA:
undetectable
5ef2V-2ftpA:
undetectable		 5ef2U-2ftpA:
12.42
5ef2V-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.21A 5ef3J-2ftpA:
undetectable
5ef3K-2ftpA:
undetectable		 5ef3J-2ftpA:
12.42
5ef3K-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.22A 5ef3Q-2ftpA:
undetectable
5ef3R-2ftpA:
undetectable		 5ef3Q-2ftpA:
12.42
5ef3R-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.22A 5ef3T-2ftpA:
undetectable
5ef3U-2ftpA:
undetectable		 5ef3T-2ftpA:
12.42
5ef3U-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 206
HIS A 207
ALA A 215
THR A 188
ILE A 219
 None
NA  A3000 (-3.8A)
None
None
None
 1.26A 5ef3U-2ftpA:
undetectable
5ef3V-2ftpA:
undetectable		 5ef3U-2ftpA:
12.42
5ef3V-2ftpA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		4 / 6 GLY A  17
SER A 233
VAL A  12
HIS A 209
 None
None
None
NA  A3000 (-3.7A)
 1.08A 5ewuA-2ftpA:
undetectable		 5ewuA-2ftpA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		4 / 6 GLY A  17
SER A 233
VAL A  12
HIS A 209
 None
None
None
NA  A3000 (-3.7A)
 1.03A 5ewuB-2ftpA:
undetectable		 5ewuB-2ftpA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 104
PRO A 149
GLN A 214
THR A 184
SER A 143
 None
None
None
None
GOL  A2001 (-2.9A)
 1.28A 5hfjG-2ftpA:
undetectable		 5hfjG-2ftpA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 234
GLN A 278
CYH A 281
 None
 0.68A 5icxC-2ftpA:
undetectable
5icxF-2ftpA:
undetectable		 5icxC-2ftpA:
20.06
5icxF-2ftpA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 296
LEU A  37
ILE A 280
ALA A 251
LEU A 237
 None
 1.23A 5ienA-2ftpA:
undetectable		 5ienA-2ftpA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 274
LEU A 273
GLY A 236
ALA A 235
SER A 290
 None
 1.06A 5ikqA-2ftpA:
undetectable		 5ikqA-2ftpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 274
LEU A 273
GLY A 236
ALA A 235
SER A 290
 None
 1.08A 5ikqB-2ftpA:
undetectable		 5ikqB-2ftpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 274
LEU A 273
GLY A 236
ALA A 235
SER A 290
 None
 1.09A 5ikrA-2ftpA:
undetectable		 5ikrA-2ftpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 274
LEU A 273
GLY A 236
ALA A 235
SER A 290
 None
 1.08A 5ikrB-2ftpA:
undetectable		 5ikrB-2ftpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 297
ALA A  40
VAL A 234
GLY A 236
ALA A 235
 None
 1.05A 5jw1A-2ftpA:
undetectable		 5jw1A-2ftpA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 297
ALA A  40
VAL A 234
GLY A 236
ALA A 235
 None
 1.08A 5jw1B-2ftpA:
undetectable		 5jw1B-2ftpA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A  93
VAL A  95
PHE A  87
GLU A  92
 None
 0.89A 5uo7A-2ftpA:
undetectable
5uo7B-2ftpA:
undetectable		 5uo7A-2ftpA:
22.98
5uo7B-2ftpA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 291
LYS A 294
ARG A 279
 None
 1.19A 6c06D-2ftpA:
undetectable		 6c06D-2ftpA:
undetectable