SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ftw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		4 / 5 HIS A  66
HIS A 191
HIS A 247
ASP A 325
 ZN  A 522 (-3.4A)
ZN  A 523 (-3.1A)
ZN  A 523 (-3.6A)
ZN  A 522 (-2.8A)
 0.60A 1e9yB-2ftwA:
21.3		 1e9yB-2ftwA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		5 / 6 HIS A  66
HIS A  68
HIS A 191
HIS A 247
ASP A 325
 ZN  A 522 (-3.4A)
ZN  A 522 (-3.3A)
ZN  A 523 (-3.1A)
ZN  A 523 (-3.6A)
ZN  A 522 (-2.8A)
 0.74A 1fweC-2ftwA:
22.1		 1fweC-2ftwA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		4 / 8 SER A 156
ALA A 188
PHE A 178
ILE A 187
 None
 1.04A 1gm7A-2ftwA:
undetectable
1gm7B-2ftwA:
undetectable		 1gm7A-2ftwA:
17.56
1gm7B-2ftwA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		4 / 8 GLU A 225
ILE A 257
PRO A 271
LEU A 319
 None
 0.86A 1hmyA-2ftwA:
undetectable		 1hmyA-2ftwA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		5 / 11 PHE A 160
SER A 108
LEU A 148
VAL A 154
PHE A 157
 KCX  A 158 ( 4.2A)
None
None
None
None
 1.48A 1q23G-2ftwA:
0.0		 1q23G-2ftwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		4 / 6 ILE A  84
VAL A 462
ILE A  98
ILE A 387
 None
 0.81A 1uwhB-2ftwA:
undetectable		 1uwhB-2ftwA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		4 / 8 THR A  94
VAL A 322
GLY A 323
ILE A 357
 None
 0.72A 2a1mB-2ftwA:
undetectable		 2a1mB-2ftwA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		4 / 8 GLY A 277
ALA A 274
GLN A 249
ILE A 300
 None
 0.71A 2dtjA-2ftwA:
undetectable
2dtjB-2ftwA:
undetectable		 2dtjA-2ftwA:
15.89
2dtjB-2ftwA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		5 / 9 ASN A 425
ILE A 426
ILE A 357
GLY A 350
ALA A 274
 None
 1.20A 2dtjA-2ftwA:
undetectable
2dtjB-2ftwA:
undetectable		 2dtjA-2ftwA:
15.89
2dtjB-2ftwA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		5 / 9 ILE A 300
ILE A 272
GLY A 277
ALA A 274
GLN A 249
 None
 1.38A 2dtjA-2ftwA:
undetectable
2dtjB-2ftwA:
undetectable		 2dtjA-2ftwA:
15.89
2dtjB-2ftwA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		5 / 8 GLU A 352
GLY A  92
THR A  94
ALA A  89
ALA A  91
 None
 1.25A 2ej3C-2ftwA:
undetectable		 2ej3C-2ftwA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		3 / 3 VAL A  28
VAL A 396
ASP A 127
 None
 0.75A 2fumD-2ftwA:
undetectable		 2fumD-2ftwA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		3 / 3 LYS A 334
GLY A 297
PRO A 299
 None
 1.00A 2hreB-2ftwA:
undetectable		 2hreB-2ftwA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		5 / 12 HIS A  66
HIS A  68
ILE A 102
HIS A 247
ASP A 325
 ZN  A 522 (-3.4A)
ZN  A 522 (-3.3A)
None
ZN  A 523 (-3.6A)
ZN  A 522 (-2.8A)
 1.12A 2pgrA-2ftwA:
13.7		 2pgrA-2ftwA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		4 / 8 ASP A 325
GLU A 270
HIS A 247
HIS A 131
 ZN  A 522 (-2.8A)
None
ZN  A 523 (-3.6A)
None
 1.08A 2q0iA-2ftwA:
undetectable		 2q0iA-2ftwA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		5 / 12 ASN A 346
ILE A 430
PHE A 294
ALA A 293
HIS A 282
 None
 1.39A 2qmjA-2ftwA:
2.1		 2qmjA-2ftwA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		3 / 3 VAL A 124
LYS A 456
HIS A 420
 None
 0.95A 3elzA-2ftwA:
undetectable		 3elzA-2ftwA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		5 / 12 PHE A 424
ILE A 426
VAL A 348
ILE A 344
VAL A 278
 None
 1.17A 3fpjB-2ftwA:
undetectable		 3fpjB-2ftwA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		5 / 12 GLY A  93
GLY A 434
SER A 356
PHE A 373
ILE A 435
 None
 1.11A 3k13A-2ftwA:
5.4		 3k13A-2ftwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		4 / 5 ARG A 305
ARG A 301
GLY A 252
GLU A 225
 None
 1.19A 3k9fA-2ftwA:
undetectable
3k9fB-2ftwA:
undetectable
3k9fC-2ftwA:
undetectable		 3k9fA-2ftwA:
22.09
3k9fB-2ftwA:
22.09
3k9fC-2ftwA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		4 / 6 ARG A 301
GLY A 252
GLU A 193
GLU A 225
 None
 0.96A 3k9fA-2ftwA:
undetectable
3k9fB-2ftwA:
undetectable
3k9fD-2ftwA:
undetectable		 3k9fA-2ftwA:
22.09
3k9fB-2ftwA:
22.09
3k9fD-2ftwA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		5 / 12 GLY A 362
LYS A 307
ARG A 354
ALA A 273
ALA A 274
 None
 1.11A 3keeD-2ftwA:
undetectable		 3keeD-2ftwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		4 / 6 GLU A 225
THR A 306
ALA A 253
ALA A 254
 None
 1.18A 3ns1C-2ftwA:
undetectable		 3ns1C-2ftwA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		5 / 12 ASP A  21
ILE A  38
ILE A  35
ASP A 395
ARG A 393
 None
 1.45A 3phaA-2ftwA:
3.8		 3phaA-2ftwA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		5 / 12 HIS A 420
VAL A  79
ASP A  80
ILE A 357
GLY A  92
 None
 0.93A 3sufD-2ftwA:
undetectable		 3sufD-2ftwA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		5 / 12 HIS A 420
VAL A  79
ILE A 357
GLY A  92
ALA A 273
 None
 0.89A 3sufD-2ftwA:
undetectable		 3sufD-2ftwA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		4 / 5 PHE A 427
GLY A 323
ILE A 357
VAL A 358
 None
 0.74A 3wrkA-2ftwA:
undetectable		 3wrkA-2ftwA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		4 / 5 PHE A 373
GLY A  92
THR A 439
VAL A 403
 None
 1.03A 3wrkD-2ftwA:
undetectable		 3wrkD-2ftwA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		4 / 8 SER A 453
GLU A 352
ARG A 354
GLY A  61
 None
 1.04A 4fgzA-2ftwA:
undetectable
4fgzB-2ftwA:
undetectable		 4fgzA-2ftwA:
20.08
4fgzB-2ftwA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		4 / 5 HIS A  66
HIS A 191
HIS A 247
ASP A 325
 ZN  A 522 (-3.4A)
ZN  A 523 (-3.1A)
ZN  A 523 (-3.6A)
ZN  A 522 (-2.8A)
 0.52A 4h9mA-2ftwA:
23.1		 4h9mA-2ftwA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		4 / 8 PRO A  60
SER A 378
VAL A 374
GLY A 400
 None
 1.01A 4mk4A-2ftwA:
undetectable		 4mk4A-2ftwA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		5 / 12 ALA A 274
GLY A 275
GLY A 277
ASP A 279
ASN A 349
 None
 1.02A 4obwB-2ftwA:
undetectable		 4obwB-2ftwA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		4 / 7 THR A  94
THR A 377
ALA A 376
THR A  65
 None
 1.03A 4qw0K-2ftwA:
undetectable		 4qw0K-2ftwA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		4 / 7 THR A  94
THR A 377
ALA A 376
THR A  65
 None
 1.03A 4qw0Y-2ftwA:
undetectable		 4qw0Y-2ftwA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		5 / 12 THR A  86
ARG A 464
TYR A 128
SER A 129
LEU A 130
 None
 1.48A 4qztC-2ftwA:
undetectable		 4qztC-2ftwA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		5 / 6 HIS A  66
HIS A  68
HIS A 191
HIS A 247
ASP A 325
 ZN  A 522 (-3.4A)
ZN  A 522 (-3.3A)
ZN  A 523 (-3.1A)
ZN  A 523 (-3.6A)
ZN  A 522 (-2.8A)
 0.60A 4ubpC-2ftwA:
22.1		 4ubpC-2ftwA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		5 / 7 THR A 229
ALA A 254
LEU A 310
LEU A 314
ILE A 257
 None
 1.33A 4ubsA-2ftwA:
undetectable		 4ubsA-2ftwA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		4 / 5 ARG A 301
GLY A 252
GLU A 225
ARG A 305
 None
 1.12A 5cdqA-2ftwA:
undetectable
5cdqB-2ftwA:
1.4
5cdqC-2ftwA:
undetectable		 5cdqA-2ftwA:
21.57
5cdqB-2ftwA:
16.48
5cdqC-2ftwA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		4 / 5 ARG A 301
GLY A 252
GLU A 225
ARG A 305
 None
 1.11A 5cdqR-2ftwA:
undetectable
5cdqS-2ftwA:
undetectable
5cdqT-2ftwA:
undetectable		 5cdqR-2ftwA:
21.57
5cdqS-2ftwA:
16.48
5cdqT-2ftwA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		3 / 3 ILE A 134
ILE A 102
MET A 145
 KCX  A 158 ( 4.2A)
None
None
 0.69A 5i9yA-2ftwA:
undetectable		 5i9yA-2ftwA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		4 / 7 PHE A 427
GLY A 323
ILE A 357
VAL A 358
 None
 0.76A 5ik1A-2ftwA:
undetectable		 5ik1A-2ftwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		3 / 3 VAL A 295
GLU A 225
GLU A 193
 None
 0.70A 5jsdB-2ftwA:
undetectable
5jsdC-2ftwA:
undetectable		 5jsdB-2ftwA:
22.36
5jsdC-2ftwA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE
(Dictyostelium
discoideum) 		5 / 12 HIS A 420
VAL A  79
ILE A 357
GLY A  92
ALA A 273
 None
 0.97A 6c2mD-2ftwA:
undetectable		 6c2mD-2ftwA:
11.96