SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ftz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		4 / 8 PHE A 193
GLY A 165
VAL A  63
PHE A 172
 None
 0.88A 1gsfA-2ftzA:
2.4		 1gsfA-2ftzA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		4 / 8 PHE A 193
GLY A 165
VAL A  63
PHE A 172
 None
 0.89A 1gsfB-2ftzA:
2.6		 1gsfB-2ftzA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		4 / 8 PHE A 193
GLY A 165
VAL A  63
PHE A 172
 None
 0.89A 1gsfC-2ftzA:
2.6		 1gsfC-2ftzA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		4 / 8 PHE A 193
GLY A 165
VAL A  63
PHE A 172
 None
 0.89A 1gsfD-2ftzA:
2.4		 1gsfD-2ftzA:
23.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 11 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.94A 1rqjA-2ftzA:
31.6		 1rqjA-2ftzA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		6 / 11 SER A  70
LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 UNL  A 273 (-3.7A)
None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.55A 1rqjA-2ftzA:
31.6		 1rqjA-2ftzA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 11 SER A  70
LEU A  71
THR A 164
GLN A 198
ASP A 201
 UNL  A 273 (-3.7A)
None
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
EDO  A 282 (-2.8A)
 0.92A 1rqjA-2ftzA:
31.6		 1rqjA-2ftzA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		6 / 11 SER A  70
LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 UNL  A 273 (-3.7A)
None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.87A 1rqjB-2ftzA:
31.6		 1rqjB-2ftzA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		6 / 11 SER A  70
LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 UNL  A 273 (-3.7A)
None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.51A 1rqjB-2ftzA:
31.6		 1rqjB-2ftzA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 11 SER A  70
LEU A  71
THR A 164
GLN A 198
ASP A 201
 UNL  A 273 (-3.7A)
None
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
EDO  A 282 (-2.8A)
 0.89A 1rqjB-2ftzA:
31.6		 1rqjB-2ftzA:
34.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 12 GLY A  96
HIS A  92
ALA A  25
ILE A  99
SER A  29
 EDO  A 277 (-3.4A)
None
None
None
None
 1.03A 1utdL-2ftzA:
undetectable
1utdM-2ftzA:
undetectable		 1utdL-2ftzA:
16.55
1utdM-2ftzA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 12 ASP A  48
THR A  44
GLY A 249
MET A 186
PHE A 176
 None
None
MLY  A 248 ( 2.4A)
None
MLY  A 181 ( 4.5A)
 1.08A 1v8bA-2ftzA:
undetectable		 1v8bA-2ftzA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 12 ASP A  48
THR A  44
GLY A 249
MET A 186
PHE A 176
 None
None
MLY  A 248 ( 2.4A)
None
MLY  A 181 ( 4.5A)
 1.11A 1v8bB-2ftzA:
undetectable		 1v8bB-2ftzA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 12 ASP A  48
THR A  44
GLY A 249
MET A 186
PHE A 176
 None
None
MLY  A 248 ( 2.4A)
None
MLY  A 181 ( 4.5A)
 1.13A 1v8bD-2ftzA:
undetectable		 1v8bD-2ftzA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 11 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.83A 1yhlA-2ftzA:
24.9		 1yhlA-2ftzA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 11 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.53A 1yhlA-2ftzA:
24.9		 1yhlA-2ftzA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 11 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.89A 1yq7A-2ftzA:
24.2		 1yq7A-2ftzA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 11 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.52A 1yq7A-2ftzA:
24.2		 1yq7A-2ftzA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.80A 1yv5A-2ftzA:
24.4		 1yv5A-2ftzA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.50A 1yv5A-2ftzA:
24.4		 1yv5A-2ftzA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 11 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.82A 2f8cF-2ftzA:
25.2		 2f8cF-2ftzA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 11 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.54A 2f8cF-2ftzA:
25.2		 2f8cF-2ftzA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.83A 2f8zF-2ftzA:
25.3		 2f8zF-2ftzA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.53A 2f8zF-2ftzA:
25.3		 2f8zF-2ftzA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 12 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.81A 2f94F-2ftzA:
25.2		 2f94F-2ftzA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 12 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.42A 2f94F-2ftzA:
25.2		 2f94F-2ftzA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.87A 2f9kF-2ftzA:
25.0		 2f9kF-2ftzA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.59A 2f9kF-2ftzA:
25.0		 2f9kF-2ftzA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 12 LEU A 178
VAL A  63
ALA A 169
CYH A 171
VAL A  42
 MLY  A 179 ( 4.3A)
None
MLY  A 187 ( 3.2A)
None
None
 1.45A 2g72A-2ftzA:
undetectable		 2g72A-2ftzA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 9 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.97A 2o1oA-2ftzA:
23.4		 2o1oA-2ftzA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 9 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.65A 2o1oA-2ftzA:
23.4		 2o1oA-2ftzA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.97A 2o1oB-2ftzA:
24.0		 2o1oB-2ftzA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.69A 2o1oB-2ftzA:
24.0		 2o1oB-2ftzA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		3 / 3 LEU A  40
PRO A  39
LEU A  43
 MLY  A   3 ( 4.6A)
None
None
 0.51A 2po5B-2ftzA:
undetectable		 2po5B-2ftzA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		3 / 3 LEU A  40
PRO A  39
LEU A  43
 MLY  A   3 ( 4.6A)
None
None
 0.53A 2po7B-2ftzA:
undetectable		 2po7B-2ftzA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 1.13A 2q58A-2ftzA:
23.6		 2q58A-2ftzA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.88A 2q58A-2ftzA:
23.6		 2q58A-2ftzA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		4 / 8 LEU A 134
ALA A  69
ALA A 111
PHE A 127
 MLY  A 133 (-4.0A)
None
None
None
 0.84A 2vcvF-2ftzA:
undetectable		 2vcvF-2ftzA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.87A 3ez3D-2ftzA:
23.7		 3ez3D-2ftzA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.54A 3ez3D-2ftzA:
23.7		 3ez3D-2ftzA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 12 ASP A  48
LEU A 259
GLY A 249
MET A 186
PHE A 176
 None
MLY  A 263 ( 4.6A)
MLY  A 248 ( 2.4A)
None
MLY  A 181 ( 4.5A)
 1.23A 3g1uD-2ftzA:
undetectable		 3g1uD-2ftzA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 11 ASP A  74
LEU A  76
ALA A 103
PHE A 108
PHE A  66
 UNL  A 273 (-3.0A)
None
None
UNL  A 273 ( 4.9A)
None
 1.42A 3n23C-2ftzA:
undetectable		 3n23C-2ftzA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 11 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.87A 3n45F-2ftzA:
25.0		 3n45F-2ftzA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 11 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.61A 3n45F-2ftzA:
25.0		 3n45F-2ftzA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.87A 3n46F-2ftzA:
24.9		 3n46F-2ftzA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.60A 3n46F-2ftzA:
24.9		 3n46F-2ftzA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 12 ASP A  48
THR A  44
GLY A 249
MET A 186
PHE A 176
 None
None
MLY  A 248 ( 2.4A)
None
MLY  A 181 ( 4.5A)
 1.14A 3n58C-2ftzA:
undetectable		 3n58C-2ftzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.85A 4kpdA-2ftzA:
25.3		 4kpdA-2ftzA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.52A 4kpdA-2ftzA:
25.3		 4kpdA-2ftzA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 9 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.85A 4kpjA-2ftzA:
24.9		 4kpjA-2ftzA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 9 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.54A 4kpjA-2ftzA:
24.9		 4kpjA-2ftzA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.87A 4kq5A-2ftzA:
24.8		 4kq5A-2ftzA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.60A 4kq5A-2ftzA:
24.8		 4kq5A-2ftzA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.84A 4kqsA-2ftzA:
25.2		 4kqsA-2ftzA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.52A 4kqsA-2ftzA:
25.2		 4kqsA-2ftzA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.85A 4n9uA-2ftzA:
25.0		 4n9uA-2ftzA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.58A 4n9uA-2ftzA:
25.0		 4n9uA-2ftzA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 12 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.86A 4ng6A-2ftzA:
24.6		 4ng6A-2ftzA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 12 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.47A 4ng6A-2ftzA:
24.6		 4ng6A-2ftzA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.81A 4nkeA-2ftzA:
25.1		 4nkeA-2ftzA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.50A 4nkeA-2ftzA:
25.1		 4nkeA-2ftzA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 9 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.87A 4nkfA-2ftzA:
25.0		 4nkfA-2ftzA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 9 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.59A 4nkfA-2ftzA:
25.0		 4nkfA-2ftzA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.81A 4nuaA-2ftzA:
25.1		 4nuaA-2ftzA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.51A 4nuaA-2ftzA:
25.1		 4nuaA-2ftzA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		6 / 12 LEU A  20
ILE A  99
ALA A 103
LEU A 107
LEU A 110
LEU A  65
 None
 0.90A 4o1zA-2ftzA:
undetectable		 4o1zA-2ftzA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 9 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.84A 4oguA-2ftzA:
24.7		 4oguA-2ftzA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 9 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.54A 4oguA-2ftzA:
24.7		 4oguA-2ftzA:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 11 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.86A 4p0wA-2ftzA:
25.1		 4p0wA-2ftzA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 11 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.59A 4p0wA-2ftzA:
25.1		 4p0wA-2ftzA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.81A 4rxdA-2ftzA:
23.7		 4rxdA-2ftzA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.51A 4rxdA-2ftzA:
23.7		 4rxdA-2ftzA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.79A 4rxdB-2ftzA:
24.0		 4rxdB-2ftzA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.51A 4rxdB-2ftzA:
24.0		 4rxdB-2ftzA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.80A 4rxdC-2ftzA:
24.1		 4rxdC-2ftzA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 10 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.51A 4rxdC-2ftzA:
24.1		 4rxdC-2ftzA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		4 / 8 SER A  70
LEU A  71
ASP A  74
ARG A  85
 UNL  A 273 (-3.7A)
None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
 0.85A 4umjA-2ftzA:
29.0		 4umjA-2ftzA:
31.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		4 / 8 SER A  70
LEU A  71
ASP A  80
ARG A  85
 UNL  A 273 (-3.7A)
None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
 0.26A 4umjA-2ftzA:
29.0		 4umjA-2ftzA:
31.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 9 SER A  70
LEU A  71
ASP A  74
ARG A  85
THR A 164
 UNL  A 273 (-3.7A)
None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
 0.80A 4umjB-2ftzA:
29.2		 4umjB-2ftzA:
31.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 9 SER A  70
LEU A  71
ASP A  80
ARG A  85
THR A 164
 UNL  A 273 (-3.7A)
None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
 0.27A 4umjB-2ftzA:
29.2		 4umjB-2ftzA:
31.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		4 / 6 HIS A  67
GLY A  34
GLU A  64
ARG A  36
 UNL  A 274 (-3.9A)
MLY  A  35 ( 2.4A)
UNL  A 274 ( 4.5A)
None
 1.02A 4zbqA-2ftzA:
undetectable		 4zbqA-2ftzA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 12 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.82A 5cg5A-2ftzA:
24.5		 5cg5A-2ftzA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 12 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.50A 5cg5A-2ftzA:
24.5		 5cg5A-2ftzA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 12 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.83A 5cg6A-2ftzA:
25.2		 5cg6A-2ftzA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 12 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.49A 5cg6A-2ftzA:
25.2		 5cg6A-2ftzA:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 12 ASP A  48
THR A  44
GLY A 249
MET A 186
PHE A 176
 None
None
MLY  A 248 ( 2.4A)
None
MLY  A 181 ( 4.5A)
 1.07A 5m66A-2ftzA:
undetectable		 5m66A-2ftzA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 12 ASP A  48
THR A  44
GLY A 249
MET A 186
PHE A 176
 None
None
MLY  A 248 ( 2.4A)
None
MLY  A 181 ( 4.5A)
 1.05A 5m66C-2ftzA:
undetectable		 5m66C-2ftzA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 12 ASP A  48
THR A  44
GLY A 249
MET A 186
PHE A 176
 None
None
MLY  A 248 ( 2.4A)
None
MLY  A 181 ( 4.5A)
 1.03A 5utuF-2ftzA:
undetectable		 5utuF-2ftzA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_A_ADNA505_1
(-)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 12 ASP A  48
LEU A 259
GLY A 249
MET A 186
PHE A 176
 None
MLY  A 263 ( 4.6A)
MLY  A 248 ( 2.4A)
None
MLY  A 181 ( 4.5A)
 1.23A 6f3nA-2ftzA:
undetectable		 6f3nA-2ftzA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_1
(-)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 12 ASP A  48
LEU A 259
GLY A 249
MET A 186
PHE A 176
 None
MLY  A 263 ( 4.6A)
MLY  A 248 ( 2.4A)
None
MLY  A 181 ( 4.5A)
 1.31A 6f3nC-2ftzA:
undetectable		 6f3nC-2ftzA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_D_ADND506_1
(-)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		5 / 12 ASP A  48
LEU A 259
GLY A 249
MET A 186
PHE A 176
 None
MLY  A 263 ( 4.6A)
MLY  A 248 ( 2.4A)
None
MLY  A 181 ( 4.5A)
 1.23A 6f3nD-2ftzA:
undetectable		 6f3nD-2ftzA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		4 / 7 LEU A  71
ASP A  74
ARG A  85
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.8A)
 1.01A 6g31D-2ftzA:
23.3		 6g31D-2ftzA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		4 / 7 LEU A  71
ASP A  80
ARG A  85
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.8A)
 0.64A 6g31D-2ftzA:
23.3		 6g31D-2ftzA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		4 / 6 LEU A  71
ASP A  74
ARG A  85
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.8A)
 1.17A 6g31J-2ftzA:
24.2		 6g31J-2ftzA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2ftz GERANYLTRANSTRANSFER
ASE
(Thermotoga
maritima) 		4 / 6 LEU A  71
ASP A  80
ARG A  85
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.8A)
 0.92A 6g31J-2ftzA:
24.2		 6g31J-2ftzA:
12.37