SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fu0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 2fu0 CYCLOPHILIN,
PUTATIVE
(Plasmodium
falciparum) 		4 / 4 GLY A 124
SER A  20
VAL A  30
LEU A  84
 None
 0.96A 1yajB-2fu0A:
undetectable		 1yajB-2fu0A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2fu0 CYCLOPHILIN,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 SER A  20
PHE A 123
THR A 127
VAL A 126
ILE A  10
 None
 1.48A 2fj1A-2fu0A:
undetectable		 2fj1A-2fu0A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2fu0 CYCLOPHILIN,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 SER A  20
PHE A 123
THR A 127
VAL A 126
ILE A  10
 None
 1.44A 2o7oA-2fu0A:
undetectable		 2o7oA-2fu0A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2fu0 CYCLOPHILIN,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 SER A  20
PHE A 123
THR A 127
VAL A 126
ILE A  10
 None
 1.46A 2xrlA-2fu0A:
undetectable		 2xrlA-2fu0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 2fu0 CYCLOPHILIN,
PUTATIVE
(Plasmodium
falciparum) 		3 / 3 GLU A  77
GLU A  79
TRP A  72
 None
 1.21A 3hrdA-2fu0A:
undetectable
3hrdE-2fu0A:
undetectable
3hrdF-2fu0A:
undetectable		 3hrdA-2fu0A:
16.31
3hrdE-2fu0A:
16.31
3hrdF-2fu0A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 2fu0 CYCLOPHILIN,
PUTATIVE
(Plasmodium
falciparum) 		5 / 10 PHE A  33
VAL A  92
PHE A 106
ILE A 136
PHE A  47
 None
 1.24A 3t3qA-2fu0A:
undetectable		 3t3qA-2fu0A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 2fu0 CYCLOPHILIN,
PUTATIVE
(Plasmodium
falciparum) 		5 / 10 PHE A  33
VAL A  92
PHE A 106
ILE A 136
PHE A  47
 None
 1.22A 3t3qB-2fu0A:
undetectable		 3t3qB-2fu0A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 2fu0 CYCLOPHILIN,
PUTATIVE
(Plasmodium
falciparum) 		5 / 10 PHE A  33
VAL A  92
PHE A 106
ILE A 136
PHE A  47
 None
 1.26A 3t3qC-2fu0A:
undetectable		 3t3qC-2fu0A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 2fu0 CYCLOPHILIN,
PUTATIVE
(Plasmodium
falciparum) 		5 / 10 PHE A  33
VAL A  92
PHE A 106
ILE A 136
PHE A  47
 None
 1.23A 3t3qD-2fu0A:
undetectable		 3t3qD-2fu0A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 2fu0 CYCLOPHILIN,
PUTATIVE
(Plasmodium
falciparum) 		4 / 4 LEU A  21
ILE A  10
GLY A 124
PHE A 106
 None
 1.06A 4dc3A-2fu0A:
undetectable		 4dc3A-2fu0A:
17.25