SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fuq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 ASP A 600
ARG A 595
ILE A 581
 None
 0.84A 1a4gB-2fuqA:
undetectable		 1a4gB-2fuqA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 5 TYR A 227
TYR A 220
PRO A  45
ASP A 221
 None
 1.37A 1i7zB-2fuqA:
2.0		 1i7zB-2fuqA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		5 / 11 HIS A 406
HIS A 202
GLU A 205
LYS A 446
TYR A 468
 None
 1.47A 1j37A-2fuqA:
2.7		 1j37A-2fuqA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		5 / 11 HIS A 406
HIS A 202
GLU A 205
LYS A 446
TYR A 468
 None
 1.48A 1j37B-2fuqA:
2.7		 1j37B-2fuqA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 7 LEU A 212
VAL A 215
GLY A 216
VAL A 177
 None
 0.67A 1p2yA-2fuqA:
undetectable		 1p2yA-2fuqA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		5 / 12 PHE A 176
GLY A 157
LEU A  51
LEU A 168
LEU A 116
 None
 1.06A 1ya4C-2fuqA:
undetectable		 1ya4C-2fuqA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 ASP A 731
ILE A 687
VAL A 739
 None
 0.68A 2avvD-2fuqA:
undetectable		 2avvD-2fuqA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 ASN A 669
ILE A 416
MET A 396
 None
 0.85A 2h42C-2fuqA:
undetectable		 2h42C-2fuqA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 LYS A 340
GLY A 388
PRO A 389
 None
 0.91A 2hreB-2fuqA:
undetectable		 2hreB-2fuqA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 ASP A 145
THR A 263
PRO A 321
 None
 0.73A 2pynB-2fuqA:
undetectable		 2pynB-2fuqA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 ASP A 480
THR A 657
PRO A 658
 None
None
PO4  A 944 ( 4.9A)
 0.56A 2pynB-2fuqA:
undetectable		 2pynB-2fuqA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 ASP A 480
THR A 657
PRO A 658
 None
None
PO4  A 944 ( 4.9A)
 0.53A 2q64B-2fuqA:
undetectable		 2q64B-2fuqA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 ASP A 145
THR A 263
PRO A 321
 None
 0.72A 2qakB-2fuqA:
undetectable		 2qakB-2fuqA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 ASP A 480
THR A 657
PRO A 658
 None
None
PO4  A 944 ( 4.9A)
 0.58A 2qakB-2fuqA:
undetectable		 2qakB-2fuqA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		5 / 12 GLN A 286
SER A 374
ASP A 291
TYR A 329
LEU A 266
 None
 1.25A 2zw9A-2fuqA:
undetectable		 2zw9A-2fuqA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		5 / 12 MET A 226
VAL A 155
ALA A 158
ALA A 184
ILE A 271
 None
 1.00A 3dl9B-2fuqA:
undetectable		 3dl9B-2fuqA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		5 / 12 GLY A 435
GLY A 431
SER A 428
ASP A 307
SER A 438
 None
 1.30A 3dlcA-2fuqA:
undetectable		 3dlcA-2fuqA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		5 / 12 ILE A 208
MET A 207
VAL A 181
VAL A 177
MET A  41
 None
 0.94A 3gwxB-2fuqA:
undetectable		 3gwxB-2fuqA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 4 ILE A 701
GLN A 696
VAL A 719
PHE A 727
 None
 1.37A 3ieoA-2fuqA:
0.0		 3ieoA-2fuqA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		5 / 12 GLU A 395
ARG A 297
ARG A 595
ASP A 425
ILE A 424
 None
None
None
ZN  A   1 (-2.4A)
None
 1.34A 3jayA-2fuqA:
1.7		 3jayA-2fuqA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 ASP A 644
ARG A 649
ARG A 297
 None
 0.99A 3k37A-2fuqA:
undetectable		 3k37A-2fuqA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 4 ARG A 447
ASP A 638
GLY A 625
THR A 633
 None
 1.14A 3k4vB-2fuqA:
undetectable		 3k4vB-2fuqA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5S_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 6 VAL A 344
ARG A 210
PHE A 267
GLU A 352
 None
 1.39A 3n5sA-2fuqA:
0.0
3n5sB-2fuqA:
0.0		 3n5sA-2fuqA:
19.50
3n5sB-2fuqA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5S_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 6 PHE A 267
GLU A 352
VAL A 344
ARG A 210
 None
 1.39A 3n5sA-2fuqA:
0.0
3n5sB-2fuqA:
0.0		 3n5sA-2fuqA:
19.50
3n5sB-2fuqA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6F_A_H4BA600_1
('NITRIC OXIDE
SYNTHASE)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 6 VAL A 344
ARG A 210
PHE A 267
GLU A 352
 None
 1.43A 3n6fA-2fuqA:
0.0
3n6fB-2fuqA:
0.0		 3n6fA-2fuqA:
19.50
3n6fB-2fuqA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6F_B_H4BB600_1
('NITRIC OXIDE
SYNTHASE)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 6 PHE A 267
GLU A 352
VAL A 344
ARG A 210
 None
 1.41A 3n6fA-2fuqA:
0.0
3n6fB-2fuqA:
0.0		 3n6fA-2fuqA:
19.50
3n6fB-2fuqA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6G_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 6 PHE A 267
GLU A 352
VAL A 344
ARG A 210
 None
 1.42A 3n6gA-2fuqA:
0.0
3n6gB-2fuqA:
0.0		 3n6gA-2fuqA:
19.50
3n6gB-2fuqA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 GLU A 651
LEU A 647
LEU A 422
 None
 0.70A 3ohtA-2fuqA:
undetectable		 3ohtA-2fuqA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 GLU A 651
LEU A 647
LEU A 422
 None
 0.72A 3ohtB-2fuqA:
2.7		 3ohtB-2fuqA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 7 LEU A 546
VAL A 728
LEU A 370
ASP A 522
 None
 0.94A 3rgfA-2fuqA:
undetectable		 3rgfA-2fuqA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 4 LYS A 397
PHE A 545
PHE A 547
VAL A 392
 None
 1.33A 3rv5A-2fuqA:
0.1
3rv5B-2fuqA:
0.7		 3rv5A-2fuqA:
7.81
3rv5B-2fuqA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 HIS A 347
SER A 214
ASN A 264
 None
 0.83A 3s8pB-2fuqA:
undetectable		 3s8pB-2fuqA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 ASP A 480
THR A 657
PRO A 658
 None
None
PO4  A 944 ( 4.9A)
 0.56A 3tkgD-2fuqA:
undetectable		 3tkgD-2fuqA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_O_CLMO221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		5 / 11 PHE A 245
HIS A 252
TYR A 246
PHE A 281
SER A 204
 None
 1.49A 3u9fM-2fuqA:
0.0
3u9fO-2fuqA:
0.1		 3u9fM-2fuqA:
15.06
3u9fO-2fuqA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		5 / 12 LEU A 168
THR A 156
TYR A 161
PHE A 180
LEU A 183
 None
 1.21A 3vw1B-2fuqA:
undetectable		 3vw1B-2fuqA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		5 / 12 TYR A 251
LEU A 258
GLY A 254
ALA A 492
PHE A 245
 None
 1.12A 3vywC-2fuqA:
undetectable		 3vywC-2fuqA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 ASP A 644
GLY A 650
TYR A 310
 None
 0.80A 3w9tC-2fuqA:
undetectable		 3w9tC-2fuqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 ASP A 644
GLY A 650
TYR A 310
 None
 0.79A 3w9tG-2fuqA:
undetectable		 3w9tG-2fuqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 8 TYR A 417
ARG A 384
ILE A 382
GLU A 648
 None
 1.06A 4a97D-2fuqA:
4.6		 4a97D-2fuqA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 6 PHE A 267
GLU A 352
VAL A 344
ARG A 210
 None
 1.45A 4ctyA-2fuqA:
0.0
4ctyB-2fuqA:
0.0		 4ctyA-2fuqA:
19.50
4ctyB-2fuqA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 LYS A 397
ILE A 509
THR A 524
 None
 0.87A 4gh8A-2fuqA:
undetectable		 4gh8A-2fuqA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 7 VAL A 561
ILE A 671
ILE A 416
ALA A 423
 None
 0.88A 4lv9A-2fuqA:
undetectable		 4lv9A-2fuqA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 4 ASN A 637
GLY A 431
ASP A 299
ASP A 309
 None
 1.40A 4n49A-2fuqA:
undetectable		 4n49A-2fuqA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 6 PHE A 628
TYR A 310
PHE A 445
ASN A 441
 None
 1.43A 4o7gB-2fuqA:
2.3		 4o7gB-2fuqA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 LEU A 323
LEU A 258
ASN A 264
 None
 0.67A 4otwA-2fuqA:
undetectable		 4otwA-2fuqA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 8 ARG A 296
ALA A 292
LEU A 289
LEU A 258
 None
 0.77A 4po0A-2fuqA:
undetectable		 4po0A-2fuqA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 8 ASP A 299
ARG A 297
ARG A 296
PRO A 389
 None
 1.22A 4uhxA-2fuqA:
1.0		 4uhxA-2fuqA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPR_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 6 VAL A 344
ARG A 210
PHE A 267
GLU A 352
 None
 1.43A 4uprA-2fuqA:
0.0
4uprB-2fuqA:
0.0		 4uprA-2fuqA:
19.50
4uprB-2fuqA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 LEU A 610
ASP A 563
ILE A 687
 PO4  A 944 ( 3.9A)
None
None
 0.66A 4xi3D-2fuqA:
undetectable		 4xi3D-2fuqA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		5 / 12 ASP A 529
GLU A 540
GLU A 709
LEU A 510
THR A 531
 None
 1.50A 4zjoA-2fuqA:
undetectable		 4zjoA-2fuqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 HIS A 347
SER A 214
ASN A 264
 None
 0.81A 5cprB-2fuqA:
undetectable		 5cprB-2fuqA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVZ_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 6 PHE A 267
GLU A 352
VAL A 344
ARG A 210
 None
 1.43A 5fvzA-2fuqA:
0.0
5fvzB-2fuqA:
0.0		 5fvzA-2fuqA:
19.50
5fvzB-2fuqA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 5 VAL A 684
THR A 607
ASN A 589
LEU A 609
 None
 1.35A 5m0iB-2fuqA:
undetectable		 5m0iB-2fuqA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 8 GLN A 696
GLY A 694
ILE A 560
ASP A 731
 None
 0.95A 5vlmH-2fuqA:
1.7		 5vlmH-2fuqA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 5 GLY A 622
GLN A 583
VAL A 654
SER A 580
 None
 1.44A 5vunA-2fuqA:
undetectable		 5vunA-2fuqA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVC_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 6 VAL A 344
ARG A 210
PHE A 267
GLU A 352
 None
 1.44A 5vvcA-2fuqA:
0.0
5vvcB-2fuqA:
0.0		 5vvcA-2fuqA:
19.28
5vvcB-2fuqA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVC_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 6 PHE A 267
GLU A 352
VAL A 344
ARG A 210
 None
 1.43A 5vvcC-2fuqA:
0.0
5vvcD-2fuqA:
0.0		 5vvcC-2fuqA:
19.28
5vvcD-2fuqA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		4 / 6 VAL A 344
ARG A 210
PHE A 267
GLU A 352
 None
 1.45A 5vvdC-2fuqA:
0.0
5vvdD-2fuqA:
0.0		 5vvdC-2fuqA:
19.28
5vvdD-2fuqA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WHY_B_SAMB504_0
(RADICAL SAM DOMAIN
PROTEIN)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		5 / 10 TYR A 525
SER A 708
THR A 730
VAL A 728
VAL A 702
 None
 1.29A 5whyB-2fuqA:
0.0		 5whyB-2fuqA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 LEU A 550
THR A 607
ASN A 606
 None
 0.71A 6baaE-2fuqA:
0.6		 6baaE-2fuqA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 LEU A 550
THR A 607
ASN A 606
 None
 0.72A 6baaF-2fuqA:
undetectable		 6baaF-2fuqA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 LEU A 550
THR A 607
ASN A 606
 None
 0.72A 6baaG-2fuqA:
0.5		 6baaG-2fuqA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 LEU A 550
THR A 607
ASN A 606
 None
 0.72A 6baaH-2fuqA:
0.5		 6baaH-2fuqA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 GLU A 651
ASP A 638
PRO A 639
 None
 0.78A 6berA-2fuqA:
undetectable		 6berA-2fuqA:
2.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 LEU A 697
LEU A 550
ARG A 700
 None
 0.55A 6fgcA-2fuqA:
undetectable		 6fgcA-2fuqA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 2fuq HEPARINASE II
PROTEIN
(Pedobacter
heparinus) 		3 / 3 LEU A 697
LEU A 550
ARG A 700
 None
 0.56A 6fgdA-2fuqA:
undetectable		 6fgdA-2fuqA:
19.65