SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2fv0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
4 / 6 PHE A  74
GLY A  45
THR A  40
PHE A  24
None
1.13A 1icuA-2fv0A:
undetectable
1icuB-2fv0A:
undetectable
1icuA-2fv0A:
21.43
1icuB-2fv0A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
4 / 6 THR A  40
PHE A  24
PHE A  74
GLY A  45
None
1.15A 1kqbC-2fv0A:
undetectable
1kqbD-2fv0A:
undetectable
1kqbC-2fv0A:
22.75
1kqbD-2fv0A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
5 / 10 LEU A  10
ALA A   5
LEU A 361
LEU A 362
ILE A  50
None
1.16A 1pcgA-2fv0A:
undetectable
1pcgA-2fv0A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
4 / 6 LEU A  95
TRP A  47
THR A  13
TYR A 356
None
1.44A 1qvuA-2fv0A:
undetectable
1qvuA-2fv0A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
3 / 3 LEU A 112
TYR A  93
GLY A  90
None
0.65A 2ocuA-2fv0A:
undetectable
2ocuA-2fv0A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
5 / 12 LEU A 289
SER A 337
TYR A 321
ARG A 277
ALA A 281
None
1.40A 2vdmA-2fv0A:
undetectable
2vdmB-2fv0A:
undetectable
2vdmA-2fv0A:
23.19
2vdmB-2fv0A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
3 / 3 ASN A  88
ASP A  41
ARG A 341
GAD  A 404 (-2.1A)
RAM  A 402 ( 4.6A)
None
0.87A 3k13C-2fv0A:
undetectable
3k13C-2fv0A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
5 / 12 LEU A  53
ALA A  99
GLY A 370
LEU A  95
ALA A 109
None
1.26A 3ou6C-2fv0A:
undetectable
3ou6C-2fv0A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
5 / 12 LEU A  53
ALA A  99
GLY A 370
LEU A  95
ALA A 109
None
1.24A 3ou7C-2fv0A:
undetectable
3ou7C-2fv0A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
5 / 12 ILE A 333
PHE A 306
ILE A 292
THR A 285
ILE A 227
None
1.05A 3pwwA-2fv0A:
undetectable
3pwwA-2fv0A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
4 / 8 TYR A 373
TYR A 236
TYR A 228
LEU A  95
None
1.33A 3uzzB-2fv0A:
undetectable
3uzzB-2fv0A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
4 / 5 LEU A 289
ALA A 224
THR A 313
PHE A 253
None
1.24A 3vasB-2fv0A:
undetectable
3vasB-2fv0A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
3 / 3 TRP A 159
VAL A 103
TRP A 101
None
1.01A 3zq8C-2fv0A:
undetectable
3zq8D-2fv0A:
undetectable
3zq8C-2fv0A:
3.75
3zq8D-2fv0A:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
4 / 6 GLY A 288
ARG A 251
ILE A 227
LEU A 232
None
1.04A 4acbC-2fv0A:
undetectable
4acbC-2fv0A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
3 / 3 PHE A  91
TYR A 228
TYR A 356
GAD  A 404 (-4.4A)
None
None
1.04A 4ffwA-2fv0A:
undetectable
4ffwA-2fv0A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
4 / 6 GLY A 226
GLY A 229
ASN A 233
ILE A 284
None
0.82A 4fglD-2fv0A:
undetectable
4fglD-2fv0A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
4 / 5 LEU A 154
PRO A 155
ILE A 131
ARG A 123
None
0.96A 4klrA-2fv0A:
undetectable
4klrA-2fv0A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
4 / 8 THR A 350
VAL A 314
LEU A 317
GLY A 336
None
0.75A 4r3aA-2fv0A:
undetectable
4r3aA-2fv0A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
4 / 6 TYR A 373
GLU A 359
TYR A 228
LEU A 152
None
1.16A 4twdB-2fv0A:
undetectable
4twdC-2fv0A:
2.4
4twdB-2fv0A:
20.34
4twdC-2fv0A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
4 / 6 TYR A 373
GLU A 359
TYR A 228
LEU A 152
None
1.19A 4twdD-2fv0A:
2.4
4twdE-2fv0A:
2.4
4twdD-2fv0A:
20.34
4twdE-2fv0A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
4 / 7 GLU A 359
TYR A 228
LEU A 152
TYR A 373
None
0.99A 4twdF-2fv0A:
undetectable
4twdJ-2fv0A:
undetectable
4twdF-2fv0A:
20.34
4twdJ-2fv0A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
4 / 6 TYR A 373
GLU A 359
TYR A 228
LEU A 152
None
1.00A 4twdF-2fv0A:
undetectable
4twdG-2fv0A:
undetectable
4twdF-2fv0A:
20.34
4twdG-2fv0A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
4 / 6 TYR A 373
GLU A 359
TYR A 228
LEU A 152
None
0.98A 4twdI-2fv0A:
undetectable
4twdJ-2fv0A:
undetectable
4twdI-2fv0A:
20.34
4twdJ-2fv0A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
4 / 8 GLY A  45
SER A  96
PHE A  74
SER A  73
None
1.02A 4ws1A-2fv0A:
undetectable
4ws1A-2fv0A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
4 / 6 TYR A 356
GLY A  90
SER A  94
LEU A  95
None
0.94A 5bphA-2fv0A:
undetectable
5bphA-2fv0A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
4 / 7 TYR A 356
GLY A  90
SER A  94
LEU A  95
None
1.04A 5bphB-2fv0A:
undetectable
5bphB-2fv0A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
4 / 4 TYR A 356
GLY A  90
SER A  94
LEU A  95
None
0.95A 5bphC-2fv0A:
undetectable
5bphC-2fv0A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
4 / 6 TYR A 356
GLY A  90
SER A  94
LEU A  95
None
1.02A 5bphD-2fv0A:
undetectable
5bphD-2fv0A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
4 / 6 ALA A 281
SER A 280
GLN A 211
ASP A 266
None
None
GAD  A 404 ( 3.2A)
None
1.22A 5c6pA-2fv0A:
undetectable
5c6pA-2fv0A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
5 / 9 ALA A 360
LEU A 289
GLY A 288
LEU A 290
LEU A 364
None
1.19A 5dqfA-2fv0A:
undetectable
5dqfA-2fv0A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
5 / 11 ALA A 224
ALA A 281
VAL A 263
LEU A 289
VAL A 257
None
1.29A 5eb5A-2fv0A:
undetectable
5eb5A-2fv0A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
5 / 10 ALA A 224
ALA A 281
VAL A 263
LEU A 289
VAL A 257
None
1.31A 5eb5B-2fv0A:
undetectable
5eb5B-2fv0A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
5 / 12 GLY A 226
GLY A 222
ARG A 221
ILE A 284
PHE A 230
None
None
GAD  A 404 (-4.0A)
None
None
1.09A 5fa8A-2fv0A:
undetectable
5fa8A-2fv0A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
3 / 3 THR A 218
SER A 191
ASP A 149
None
None
GAD  A 404 (-3.8A)
0.45A 5kvaA-2fv0A:
undetectable
5kvaA-2fv0A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
3 / 3 THR A 218
SER A 191
ASP A 149
None
None
GAD  A 404 (-3.8A)
0.47A 5kvaB-2fv0A:
undetectable
5kvaB-2fv0A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
5 / 10 LEU A 242
GLY A 229
GLY A 226
LEU A 178
ALA A 177
None
1.06A 5o96G-2fv0A:
undetectable
5o96H-2fv0A:
undetectable
5o96G-2fv0A:
22.49
5o96H-2fv0A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
5 / 12 ALA A 281
TRP A 372
TYR A 356
ALA A 224
GLY A 222
None
1.20A 5tzoB-2fv0A:
undetectable
5tzoB-2fv0A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
4 / 7 ASN A 233
SER A 180
ILE A 146
LEU A 151
None
0.97A 5u4sA-2fv0A:
undetectable
5u4sA-2fv0A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB311_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
4 / 4 PHE A  46
PRO A 155
TYR A 356
TYR A 228
None
1.00A 5uunB-2fv0A:
0.0
5uunB-2fv0A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
4 / 7 ASN A  39
ASN A  83
GLU A  82
ARG A  80
None
1.21A 6b8kA-2fv0A:
undetectable
6b8kA-2fv0A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus
sp.
GL1)
3 / 3 LEU A 184
GLY A 222
PHE A  91
None
None
GAD  A 404 (-4.4A)
0.57A 6exiC-2fv0A:
undetectable
6exiC-2fv0A:
13.87